Wyniki wyszukiwania - Biblioteka Nauki

1

Plasma thyroid hormones and corticosterone levels in blood of chicken embryos and post hatch chickens exposed during incubation to 1800 MHz electromagnetic field

100%

Pawlak K. , Sechman A. , Nieckarz Z.

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nr 1

114-122

EN

Introduction: This study attempted to determine the effect of a 1800 MHz electromagnetic field (EMF) (only carrier frequency) on thyroxine (T₄), triiodothyronine (T₃) and corticosterone (CORT) concentrations in the blood plasma of chick embryos, and to investigate the effect of electromagnetic field (EMF) exposure during embryogenesis on the level of these hormones in birds that are ready for slaughter. Material and Methods: Throughout the incubation period, embryos from the experimental group were exposed to a 1800 MHz EMF with power density of 0.1 W/m², 10 times during 24 h for 4 min. Blood samples were collected to determine T₄, T₃ and CORT concentrations on the 12th (E12) and 18th (E18) day of incubation, from newly hatched chicks (D1) and from birds ready for slaughter (D42). Results: The experiment showed that T₄ and T₃ concentrations decreased markedly and CORT levels increased in the embryos and in the newly hatched chicks exposed to EMF during embryogenesis. However, no changes were found in the level of the analyzed hormones in the birds ready for slaughter. Differences in T₄ and T₃ plasma concentrations between the EMF-exposed group and the embryos incubated without additional EMF were the highest in the newly hatched chicks, which may be indicative of the cumulative effect of electromagnetic field on the hypothalamo-pituitary-thyroid axis (HPT). Discussion: The obtained results suggest that additional 1800 MHz radio frequency electromagnetic field inhibits function of HPT axis, however, it stimulates hypothalamo- pituitary-adrenal axis by inducing adrenal steroidogenic cells to synthesize corticosterone. Further investigations are needed to elucidate the mechanisms by which radio EMFs affect HPT and HPA axis function in the chicken embryos.

2

Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction

100%

Omon E. A. , Ajay O. D.

European Journal of Clinical and Experimental Medicine

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2023

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nr 4

768-775

EN

Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.

3

Fever induced oxidative stress: the effect on thyroid status and the 5'-monodeiodinase activity, protective role of selenium and vitamin E

100%

Brzezinska-Slebodzinska E.

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2001

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tom 52

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nr 2

4

Effect of leptin on thyroid-stimulating hormone secretion and nitric oxide release from pituitary cells of ewe lambs in vitro

86%

Radwanska P. , Kosior-Korzecka U.

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nr 1

5

Effects of polybrominated diphenyl ethers on thyroid hormone, neurodevelopment and fertility in rodents and humans

86%

Czerska M. , Zieliński M. , Kamińska J. , Ligocka D.

International Journal of Occupational Medicine and Environmental Health

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2013

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tom 26

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nr 4

498-510

EN

Polybrominated diphenyl ethers (PBDEs) are used as flame retardants. Due to their widespread use in many consumer products, PBDEs can be found in food as well as in the environment. Their presence has also been found in the human serum, human adipose tissue and human breast milk. Results of experimental studies suggest that the presence of PBDE in the environment is not neutral to our health. In rats and mice exposed to PBDE disturbances in thyroid hormone homeostasis and reproductive system such as changes in reproductive organs weight and disorders in sperm motility and motion were found. In rodents, pre- and postnatal exposure to PBDE can cause neurobehavioral effects. Also in humans disturbances in thyroid hormone system, weight of reproductive organs and concentrations of sex hormones associated with PBDEs serum concentrations were found. Exposure to PBDEs during pregnancy may lead to slower mental and psychomotor development in infants. In this paper the results of previous animal a nd human studies are reviewed.

6

Effect of lithium carbonate on the function of the thyroid gland: mechanism of action and clinical implications

86%

Czarnywojtek A. , Zgorzalewicz-Stachowiak M. , Czarnocka B. , Sawicka-Gutaj N. , Gut P. , Krela-Kazmierczak I. , Ruchala M.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 2

7

Effect of triiodothyronine on phospholipid metabolism in skeletal muscles of the rat

86%

Zendzian-Piotrowska M. , Gorska M. , Dworakowski W. , Gorski J.

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2000

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tom 51

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nr 1

8

Clinical and pathological observations and treatment of congenital goitre in kids

86%

Ozmen O. , Sahinduran S. , Sezer K.

Bulletin of the Veterinary Institute in Puławy

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2005

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tom 49

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nr 2

9

Simultaneous determination of plasma ovarian and thyroid hormones during sexual maturation of the hen [Gallus domesticus]

86%

Sechman A. , Paczoska-Eliasiewicz H. , Rzasa J. , Hrabia A.

Folia Biologica

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2000

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tom 48

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nr 1-2

10

Serum concentrations of thyroid hormones during egg laying in two types of Japanese quail [Coturnix coturnix japonica]

86%

Janan J. , Rudas P. , Bartha T. , Ludrovszky F.

Archivum Veterinarium Polonicum

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1994

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tom 34

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nr 3-4

11

Mitochondrial tRNA in hyperthyroidism

86%

Pasternak K. , Szymonik-Lesiuk S. , Brzuszkiewicz-Zarnowska H. , Borkowski T.

Acta Biochimica Polonica

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1995

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tom 42

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nr 2

EN

The mitochondrial tRNA were prepared from liver and brain tissues of thyroxinized and control rabbits. The presence of tRNA for twenty amino acids both in liver and brain mitochondria was revealed. The quantity of radioactive amino acids bound to the mitochondrial tRNA was higher in hyperthyreosis than in control animals but considerable differences between the brain and liver tissues were observed.

12

Effect of goitrogenic alliloisothiocyanate on thyroid hormones and serum lipid profile in rats

86%

Kostogrys R. B. , Pisulewski P. M. , Pecio A.

Polish Journal of Food and Nutrition Sciences

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2007

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tom 57

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nr 1

EN

The objectives of the present study were to estimate the effects of increasing levels of the goitrogenic alliloisothiocyanate on body weight, thyroid hormones, morphology of thyroid follicles, and serum lipoproteins concentration. Twenty-four, growing male rats of Wistar strain were randomly assigned to four experimental groups (I – 0, II – 2, III – 4, and IV – 6 mg alliloisothiocyanate per kg body weight). For 20 days the rats were fed restricted amounts of AIN’93G diets and had free access to distilled water. Animal body weight was recorded weekly. No visible signs of alliloisothiocyanate toxicity were observed in this study. Feeding graded amounts of alliloisothiocyanate to rats resulted in insignificantly decreased serum concentrations of fT4 (by 30.5%). No significant effect of dietary alliloisothiocyanate on TSH concentrations was noted. In addition, alliloisothiocyanate altered thyroid follicle morphology as indicated by both hyperplasia and hypertrophy of the follicular epithelial cells. Goitrogenic alliloisothiocyanate was found to decrease serum total cholesterol and serum LDL-cholesterol (24% and 30%, respectively).

13

The effect of dietary conjugated linoleic acid on the levels of lipids, cholesterol and iodothyronines in the blood of pigs

72%

Sechman A. , Pieszka M. , Rzasa J. , Migdal W. , Wojtysiak D. , Pustkowiak H. , Zivkovic B. , Pasciak P.

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2007

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tom 16

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nr 2

193-204

14

Sex-dependent changes in cerebellar thyroid hormone-dependent gene expression following perinatal exposure to thimerosal in rats

72%

Khan A. , Sulkowski Z. L. , Chen T. , Zavacki A. M. , Sajdel-Sulkowska E. M.

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2012

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tom 63

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nr 3

15

Effect of thermal stress on physiological parameters of broiler chickens after injection of linseed oil into the yolk sac

72%

Sosnowka-Czajka E. , Skomorucha I. , Herbut E.

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nr 1

16

Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders

72%

Khan A. , Harney J. W. , Zavacki A. M. , Sajdel-Sulkowska E. M.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 2

17

Thyroid hormone and thyreotropin (TSH) association with densitometric parameters in children

72%

Porwik E. , Matusik P. , Drzyzdzyk K.

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2009

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tom Vol. 13

141--144

EN

The influence of TSH on bones is still vastly unknown and the information that is known is considered controversial. This important relationship has not been studied in detail. The aim of our research was to assess the correlation between TSH, thyroid hormone and bone mineral density in children measured by DXA scanning. Our study group included 36 children (16 girls and 20 boys) mean age 12.9 š 3.3 years. Basic anthropometrical measurements were performed (height, weight, body mass index-BMI), in all subjects. Blood was collected and measured for TSH and FT4. Bone mineral density of lumbar spine (L2-L4 BMD) and total body (Total Body BMD) were measured by DXA and expressed as bone mineral content (BMC [g]) and bone mineral density (BMD [g/cm2]). BMD Z-Score was also calculated. Correlation between the parameters obtained by DXA and anthropometrical data, TSH and thyroid hormone concentration were calculated. A statistically significant positive correlation was observed between height, weight and BMI and BMD which was calculated. Weight and BMI also had a statically significant correlation with Z-Score and total bone mineral content (BMC – expressed in grams). There was a statistically significant positive correlation between TSH level and Z-Score for both L2-L4 lumbar spine and for total body. TSH did not correlate significantly with BMD [g/cm2] and BMC [g]. FT4 was negatively and significantly correlated with Z-Score for both L2-L4 lumbar spine and for total body. There was also no significant correlation between FT4 and BMD [g/cm2] and BMC [g]. Conclusion: 1. Thyroid stimulating-hormone (TSH) appears to be associated with maintenance of bone mineral density in children. 2. BMD Z-Score especially from L2-L4 lumbar spine assessed by DXA scanning is correlated best with hormonal and biochemical factors potentially influencing bone mineralization in children.

18

Thyroid hormone at supra-physiological dose optimizes cardiac geometry and improves cardiac function in rats with old myocardial infarction

72%

Pantos C. , Mourouzis I. , Tsagoulis N. , Markakis K. , Galanopoulos G. , Roukounakis N. , Perimenis P. , Liappas A. , Cokkinos D. V.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 3

49-56

EN

Thyroid hormone (TH) is critical in cardiac cell differentiation (regulating contractile proteins and cell geometry) and this effect could be potentially exploited therapeutically in reversing the process of de-differentiation which underlies postischemic cardiac remodeling. Acute myocardial infarction was induced in male Wistar rats by ligating left coronary artery (AMI, n=8), while sham operated animals served as control (SHAM, n=8). 13 weeks after AMI, TH was administered in a group of animals for 4 weeks (AMI-THYR, n=9). TH significantly increased ß-MHC and decreased -MHC expression in the myocardium. This response was accompanied by changes in cardiac geometry: sphericity index, (SI, long to short axis ratio) was found to be 1.95 (SEM, 0.02) in SHAM, 1.51(0.03) in AMI and 1.64(0.03) in AMI-THYR, p<0.05. As a consequence, cardiac function was significantly improved: left ventricular ejection fraction (EF%) was 74.5% (SEM, 2.8) in SHAM vs 29.5% (2.1) in AMI, and 40.0% in AMI-THYR, p<0.05. Furthermore, +dp/dt and -dp/dt were 4250 (127) and 2278 (55) in SHAM vs 2737(233) and 1508 (95) in AMI vs 3866 (310) and 2137(111) in AMI -THYR, respectively, p<0.05. TH treatment partially reverses cardiac dysfunction in rats with old myocardial infarction by favorably changing cardiac chamber geometry and expression of myosin isoforms. Thyroid hormone, unlike current treatments, appears to be a paradigm of therapeutic intervention which aims at restoring cardiac geometry and may prove new effective treatment for heart failure.

19

Effects of xylazine on thyroid hormones, insulin, and glucagon in dogs

72%

Gao L. , Zhang Z. , Zhang J. , Wang H.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 3

EN

In this study, the effects of xylazine on serum levels of triiodothyronine (T3), tetraiodothyronine (T4), insulin (INS), and glucagon (GN) in dogs were investigated. The dogs before injection were used as control group (0 h). The dogs were injected with xylazine at 3 mg/kg, then blood was collected from the peripheral veins at 0.5, 2, 8, 24, 48, 72, and 120 h after the injection. Serum T3, T4, INS, and GN were measured by ELISA. The results revealed that the T3 level decreased in serum 0.5 h after the injection (P<0.05), while the change in T4 was not significant. The secretion of INS increased 8 h after the injection (P<0.05). The GN level increased 2 h and 8 h after the injection (P<0.05). However, all of these changes returned to the norm after 24 h.

20

Dendritic cells in autoimmune disorders and cancer of the thyroid

72%

Lewinski A. , Sliwka P. W. , Stasiolek M.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 1