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3 Medycyna Doświadczalna i Mikrobiologia

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Zakazenia ran wywolane przez maczugowce reprezentujace gatunki bakterii uwazanych za oportunistyczne

100%

Olender A. , Letowska I.

nr 2

135-140

Przeprowadzono analizę 24 przypadków izolacji z ran w znamiennej ilości Gram-dodatnich maczugokształtnych pałeczek (C. amycolatum, C. striatum, C. grupa G, Brevibacterium sp., C. jeikeium, C. urealyticum, C. grupa F1). Scharakteryzowano oporność na antybiotyki na podstawie wartości MIC oznaczonych metodą Etest. U 83,3% szczepów występowała jednocześnie oporność na erytromycynę i klindamycynę (mechanizm MLSB), u 75% oporność na kotrimoksazol, u 71,7% oporność na chloramfenikol, u 16,7% na antybiotyki beta-lakatamowe. Wszystkie szczepy wykazywały wrażliwość na wankomycynę i teikoplaninę.

Wound infections are often due to endogenous bacterial flora which penetrates into a site of injury. The establishment of the etiologie agent can be problematic, especially when opportunistic bacteria are present, suggesting contamination of clinical material. Among bacteria that can cause such diagnostic problems are opportunistic Corynebacterium spp. and coryneforms colonizing skin. The aim of the study was to analyze the 24 clinical samples collected from wounds of different location, with Gram positive rods isolated in numbers suggesting the cause of infection. Bacterial identification was performed by API Coryne and additional biochemical tests (API ZYM, API NE). It was detected that the commonest species isolated were: C. amycolatum (29,2%), C. striatum (16,7%), C. group G (16,7%) and Brevibacterium spp., C.jeikeium, C. urealyticum, C. group F1. The drug susceptibility testing was performed by E-test method. Among isolated strains, 83.3% were simultaneously resistant to erythromycin and clindamycin. In 75% cases resistance to co-trimoxazole was noted, in 71.7% resistance to chloramphenicol and in 16.7% resistance to beta-lactams were detected. In presented study the high percentage of strains resistant to macrolids and linkosamids (MLSB) was noted. All strains were susceptible to vancomycin and teicoplanin.

Zmiany wrazliwosci Staphylococcus aureus na bakteriobojcze dzialanie teikoplaniny zwiazane z obecnoscia roznych profagow w genomie bakteryjnym

100%

Mlynarczyk G. , Mlynarczyk A. , Zabicka D. , Luczak M.

Medycyna Doświadczalna i Mikrobiologia

2003

tom 55

nr 3

203-207

Oceniano wpływ obecności profagów wbudowanych w genom szczepu NCTC 8325-4 na wartości MIC i MBC teikoplaniny. Bakteriofagi otrzymane były z wielolekoopornych szczepów Staphylococcus aureus.

The influence exerting by lysogeny state on the susceptibility of Staphylococcus aureus to bactericidal action of teicoplanin was studied. In this aim the standard, non-lysogenic, bacteriophage-free S.aureus NCTC 8325-4 strain was lysogenized with 10 different, bacteriophages obtained in our laboratory. All bacteriophages were derived from multiresistant S. aureus strains and all were able to convert staphylokinase. For all derivatives MBCs and MICs of teicoplanin were determined. In the case of four strains the ratio MBC/MIC showed the presence of tolerance to teicoplanin (MBC/MIC ≥32) and was significantly higher than in the case of the parent strain NCTC8325-4. In the case of two strains this ratio was smaller than for parent strain. Only small correlation with our previous results obtained for vancomycin was observed.

Wplyw skojarzonego dzialania metycyliny i teikoplaniny na szczepy Staphylococcus aureus w badaniach in vitro

80%

Mlynarczyk A. , Mlynarczyk G. , Luczak M.

2005

tom 57

nr 1

1-6

W ostatnich latach wankomycyna i teikoplanina są bardzo często stosowane, a niejednokrotnie nawet nadużywane w leczeniu przeciwbakteryjnym chorych hospitalizowanych. Są lekami z wyboru zarówno w leczeniu zakażeń spowodowanych przez metycylino-oporne szczepy Staphylococcus aureus (MRSA), jak i zakażeń gronkowcami koagulazo-ujemnymi.

The synergy or antagonism between teicoplanin and methicillin against the methicillin-resistant strains of Staphylococcus aureus with decreased susceptibility to vancomycin was studied using agar dilution and E-tests. The investigated strains were GISA and h-GISA isolated in our laboratory as well as standard. In the used range of concentrations, a synergy was shown in the case of two strains and an antagonism was shown in the case of other two strains. For the most strains the tested combination of antibiotics showed indifference. The antagonistic effect was observed in the case of the standard strain Mu3 and the one from eight strains h-GISA isolated in our laboratory.