Wyniki wyszukiwania - Biblioteka Nauki

1

Tablets for inclusive teaching and learning in a mainstream setting - a need analysis

100%

Galanciak S. , Weiss A. , Judge M. , Grebe C. , Nunez C. , Graf J. , Tanaś M. , Kehl F.

International Journal of Pedagogy, Innovation and New Technologies

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2018

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tom 5(2)

1-10

EN

The article presents the results of international research on the use of mobile technologies as a support in the process of educating students with special educational needs. A team of researchers from five European countries conducted a survey among teachers using tablets while working with students with disabilities. Answers from the respondents reveal the image of educators who seek on their own, without any systemic support, opportunities to strengthen the educational opportunities of their pupils. The research results indicate that systemic organizational, methodical and financial solutions should be developed to facilitate the introduction of mobile devices for special and inclusive education.

2

THE EXCIPIENTS USED IN THE NON-COATED TABLETS - A REVIEW

100%

POLSKI A. , IWANIAK K. , NALEŚNIAK M. , POLESZAK E.

Medicina Internacia Revuo

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2014

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tom 26

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nr 102

10-18

EN

In modern drug technology excipients fulfill many important roles: antiadherents, binders, disintegrants, fillers, flavours, lubricants, etc. They can modify many properties of tablets including disintegration time, substance release place (stomach, intestine) and time (fast or slow release, non-modified), improvement of taste and flavor, etc. There are many scientific reports that can help choose suitable excipients to produce tablets that have desired properties. That paper was created to arrange knowledge about them.

3

Przygotowanie próbek do analizy tabletek

100%

Steinbach A.

Laboratorium - Przegląd Ogólnopolski

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2013

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tom nr 5-6

56--57

PL

Z reguły pierwszym krokiem jest poddanie tabletki procesowi homogenizacji w odpowiedniej mieszaninie rozpuszczalników. W zależności od zastosowanej techniki oznaczenia wymagane są takie kroki jak dodatkowe rozcieńczenie próbki lub jej odpipetowanie. W większości laboratoriów powyższe etapy przeprowadzane są na drodze manualnej, co skutkuje pojawieniem się efektu przenoszenia próby, zanieczyszczeniem krzyżowym, a w konsekwencji niepowtarzalnością wyników. Ponadto czynności manualne są czasochłonne, żmudne i uzależnione od wielu różnych czynników.

EN

The first step is always the through homogenisation of the tablet in a suitable solvent mixture. Depending on the determination technique applied, steps such as additional dilution or pipetting are required. In most labs these steps are carried out manually, which can results in carryover or erratic results, as the time-consuming and tedious manual operations are influenced by many different circumatances.

4

A simple HPLC method containing greener modifier and slighter temperature elevated for simultaneous determination of three statin drugs in tablets

100%

Alshitari W. , Al-Shehri F. , Abd El-Hady D. , Albishri H. M.

Acta Chromatographica

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2022

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tom Vol. 34, no. 2

210--215

EN

Statins drugs are thought to be among the most prescribed drugs worldwide for the treatment of hypercholesterolaemia. A simple and reliable RP-HPLC method has been successfully employed for simultaneously separating and qualifying three statin drugs including atorvastatin, rosuvastatin and simvastatin in pharmaceutical tablets. The optimal conditions were mobile phase 50:50 (v/v) (formic acid pH 2.50: ETOH), column temperature 40.00 °C, detection wavelength 238.00 nm, and flow rate 1.00 mL/min. The proposed method has been validated based on the ICH guidelines in terms of linearity, precision, accuracy, and limit of detection and limit of quantification. The linear range investigated 2.0–80.0, 4.0–100.00, and 12.00–120.00 µg/mL for rosuvastatin, atorvastatin and simvastatin respectively with coefficients of determination (R2) within the range of 0.9993–0.9995. The LOD and LOQ for rosuvastatin, atorvastatin and simvastatin were (1.57, 4.76 µg/mL), (1.87, 5.66 µg/mL), (3.46, 10.49 µg/mL) respectively. In addition, in order to evaluate the feasibility of the method developed, it was employed towards the quantification of the pharmaceutical tablets for the analytes investigated and excellent recovery was obtained.

5

Pedagogical premises of the use of tablets in the teaching process

100%

Siemieniecki B. , Majewska K.

The New Educational Review

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2015

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tom 42

65-76

EN

The article is a summary of one part of the research conducted in the Department of Didactics and Media in Education, regarding the use of tablets in the teaching process. The paper provides an overview of the frequency of use, as well as ways of using the tools by students of the humanities. It presents the relationship between the presence of tablets in the teaching process and the cognitive-constructivist nature of acting. The presented study was carried out among 396 students of the humanities. The study used diagnostic survey methods, as well as the pedagogical crossover experiment.

6

Review on analgesic effect of co-administrated ibuprofen and caffeine

100%

Polski A. , Kasperek R. , Sobotka-Polska K. , Poleszak E.

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2014

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tom 27

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nr 1

10-13

EN

Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.

7

Simultaneous analysis of eprosartan and hydrochlorothiazide in tablets by high-performance thin-layer chromatography with ultraviolet absorption densitometry

88%

Patel H. U. , Suhagia B. N. , Patel C. N.

Acta Chromatographica

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2009

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tom Vol. 21, no. 2

319--326

EN

A new, simple, accurate, and precise high-performance thin-layer chromatographic (HPTLC) method has been established for simultaneous analysis of eprosartan and hydrochlorothiazide in tablet formulations. Standard and sample solutions of eprosartan and hydrochlorothiazide were applied to precoated silica gel G 60 F 254 HPTLC plates and the plates were developed with benzene-methanol-formic acid 7:3:0.1 ( υ/υ ) as mobile phase. Detection and evaluation of chromatograms was performed densitometrically at 272 nm. The retention factors of eprosartan and hydrochlorothiazide were 0.76 and 0.57, respectively. The linear range was 4.8–43.2 μg per spot for eprosartan and 0.15–1.35 μg per spot for hydrochlorothiazide; the correlation coefficients, r , were 0.998 and 0.999, respectively. The method was validated and successfully used for analysis of the drugs in tablets.

8

Selective RP-HPLC DAD method for determination of tenofovir fumarate and emtricitabine in bulk powder and in tablets

88%

Abdelhay M. H. , Gazy A. A. , Shaalan R. A. , Ashour H. K.

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2015

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tom Vol. 27, no. 1

41--54

EN

A simple and selective liquid chromatographic method was developed for the simultaneous determination of tenofovir disoproxil fumarate (TEN) and emtricitabine (EMT) in combined tablets. The method is based on separation of TEN and EMT on a Zorbax SB-C8 column, 5 μm, 4.6 × 250 mm, with a mobile phase consisting of 50 mM disodium hydrogen phosphate-acetonitrile (50:50, v/v). The mobile phase contains 0.1% triethylamine (TEA) and was adjusted to pH 6.0. Quantification of the analytes is achieved with diode array — ultraviolet detector (DAD-UV) at 260 and 280 nm for TEN and EMT, respectively, based on peak area. Different variables affecting the method were carefully investigated and optimized. Reliability and analytical performance of the proposed method, including linearity, range, precision, accuracy, and detection and quantitation limits, were statistically validated. The high-performance liquid chromatography (HPLC) method was successfully applied for determination of each drug in their binary tablets.

9

Co potrafi LiDAR dla mas?

75%

Zięba-Kulawik K. , Kulawik T. , Wężyk P.

Geodeta : magazyn geoinformacyjny

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2020

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tom nr 8

28--30

10

Stability-indicating HPLC method for simultaneous determination of degradation products and process-related impurities of avanafil in avanafil tablets

75%

Kumar N. , Sangeetha D. , Kalyanraman L. , Sainath K.

Acta Chromatographica

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2018

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tom Vol. 30, no. 3

158--163

EN

The objective of the current research is to understand the degradation behavior of avanafil under different stress conditions and to develop a stability-indicating high-performance liquid chromatography (HPLC) method for simultaneous determination of degradants observed during degradation. Avanafil tablets were exposed to acid, base, water, oxidative, thermal, and photolytic degradation conditions. In acid, oxidative, thermal, and humidity degradation, significant degradation was observed. All the degradants observed during degradation were separated from known impurities of avanafil by using reverse-phase (RP)-HPLC. Mobile phase A, 0.1% trifluoro acetic acid and triethylamine in water, and mobile phase B, water and acetonitrile in the ratio of 20:80 (v/v), were used at a flow rate of 1.2 mL/min in gradient elution mode. Separation was achieved by using Inertsil ODS 3 column (3 μm, 4.6 mm × 250 mm) at 45 °C. Peak responses were recorded at 245 nm. Method capability for detecting and quantifying the degradants, which can form during stability, was proved by demonstrating the peak purity of avanafil peak in all the stressed samples. Mass balance was established by performing the assay of stressed sample against reference standard. Mass balance was found >97% for all the stress conditions. The developed analytical method was validated as per International Conference on Harmonization (ICH) guidelines. The method was found specific, linear, accurate, precise, rugged, and robust.

11

Do tablets mean educational change? The materiality, hybridity and performativeness of teaching and learning practices in tablet-mediated classroom

75%

Kopciewicz L. , Bougsiaa H.

International Journal of Pedagogy, Innovation and New Technologies

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2017

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tom 4(2)

15-26

EN

This text presents and discusses results of empirical research conducted during 3 school semesters (1.5 of school year) in a primary school in Poland. The research focused on the introduction of tablets (iPads) to didactic design and aimed at the observation of learning processes of the entire school community in connection with the appearance of a new educational actor. We used a qualitative research approach, mainly video-ethnography (60 hours of recorded material). This research approach resulted in the identification of maps of teaching and learning practices in the changing school field.

12

Determination of triamcinolone acetonide in pharmaceutical formulation and human serum by adsorptive cathodic stripping voltammetry

63%

Hammam E.

Chemia Analityczna

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2007

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tom Vol. 52, No. 1

43-53

EN

Electrochemical behavior of triamcinolone acetonide (TAA) has been studied by cyclic voltammetry at a hanging mercury drop electrode in universal buffers of pH 2-11. Due to the interfacial adsorption of triamcinolone acetonide onto the mercury surface, a fully validated square-wave adsorptive cathodic stripping voltammctric procedure was developed for its determination in the bulk form. Under optimized conditions, the stripping voltammetric peak current of triamcinolone acetonide showed a linear dependence on TAA concentration over the range 1 x 10-9-9 x 108 mol L-1. The mean percentage recovery of TAA was 99.84 š 0.64, the detection limit {LOD) was 3 x 10-10 mol L-1, and the quanlitation limit (LOQ) equaled 1 x 10-9 mol L-1. The proposed procedure was successfully applied in the determination of triamcinolone acetonide in Kenacort'K tablets and in human serum spiked with TAA without any pretreatment and/or time-consuming extractions prior to the analysis. LOD and LOQ corresponding to the determination of triamcinolone acetonide in spiked human serum were 7.5 x10-10 mol L-1 and 2,5 x 10-9mol L-1, respectively.

PL

Badano elektrochmiczne zachowanie acetonidu triamcinolonu (TAA) metodą cyklicznej woltamperometrii na elektrodzie rtęciowej w przedziale pH 2-11. Ponieważ stwierdzono adsorpcję TAA na powierzchni rtęci, do oznaczania tego związku zastosowano procedurę wykorzystującą wiszącą elektrodę rtęciową i adsorpcyjną, katodową woltamperometrię strippingową, W warunkach optymalnych otrzymano liniową zależność między wysokością piku woltamperometrycznego i stężeniem TAA w zakresie 1 x 10-9-9x 10-8mol L-1. Średni odzysk wyniósł 99.84 š 0.64 %, granica wykrywalności 3 x 10-9 mol L-1 a granica oznaczalności l x 10-9 mol L-1. Opacowaną procedurę zastosowano do oznac/.ania TAA w tabletkach Kenacort* i w ludzkiej surowicy krwi po dodaniu analitu. Nie było porzeby przeprowadzenia wstępnych działań chemicznych i ekstrakcji. Granicę wykrywalności i granicę oznaczalności w surowicy krwi oznaczono odpowiednio jako 7,5 x 10-10 mol L-1 i 2,5x 10 mol L-1.

13

How Children Use the Internet?

63%

JAKOVLJEVIĆ N. , HILČENKO S.

Edukacja-Technika-Informatyka

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2019

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tom 10

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nr 3

109-112

EN

The younger population, even children at pre-school age, spend most of their time on the Internet. It is the concept of a new generation – the generation Z. From the earliest age they spend time with IT devices (tablets, mobile phones, computers ...). How these kids actually use the Internet is something that parents are rarely concerned about. It is often the case that kids know more about IT devices than their parents. Moreover, parents are often confronted with children due to inconsistent use of the Internet. One way to properly use the Internet is education.

14

Rehabilitation of cognitive impairment with the RehaMob

63%

Dobosz K. , Wojaczek M. , Dobosz M. , Drzastwa A.

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tom Vol. 24

239--245

EN

The aim of the study was a continuation of previously provided research on the tablets usability in the rehabilitation of old patients with cognitive disabilities after a brain stroke. First, the analysis of the pilot research results was provided. It gave a hope for possible rationalization of the rehabilitation process after proper improvement of the proposed mobile solution. Prototype examples of mobile rehabilitation applications were extended and integrated in the RehaMob - a single mobile solution. The mobile application includes six different types of tasks, which can be useful for stimulation and rehabilitation of language functions, short-term memory, etc. The RehaMob was made available again to the therapists in the rehabilitation center. Finally, the mobile application is used with good results in the therapy of patients with cognitive disabilities. The mobile solution is useful support for traditional rehabilitation process, but its influence to the rehabilitation progress is difﬁcult to assess, because the RehaMob can be used only as additional tool.

15

Rapid determination of nifuroxazide in tablets by near-infrared spectroscopy

63%

Sobanska A. W.

Chemia Analityczna

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2009

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tom Vol. 54, No. 5

1021-1033

EN

A novel method of quantification of nifuroxazide in pharmaceutical tablets by near-infrared ' reflectance spectroscopy was elaborated. The analysis was based on a S1MCA model gene- ; rated for pulverized nifuroxazide tablets and a set of calibration standards prepared by j mixing nifuroxazide with starch (weight percent of nifuroxazide 0-100%). Linear relationship between the principal component PCI calculated for the NIR reflectance spectra of the calibration standards and the contents of nifuroxazide was established. The calibration plot obtained this way allowed for quantification of nifuroxazide content in pharmaceutical tablets. Additionally, NIR reflectance spectra of the calibration standards were converted ' into 2nd derivatives. A number of analytical wavelengths were selected, for which separate calibration plots were constructed. Results of quantification of nifuroxazide in tablets using these plots were comparable to those obtained by the PC 1 method. Both versions of the NIR reflectance method of quantification of nifuroxazide content in tablets were simple, fast, and sufficiently accurate for routine analysis.

PL

Opracowano nową metodę ilościowego oznaczania nifuroksazydu w tabletkach farmaceutycznych za pomocą spektroskopii w bliskiej podczerwieni w odbiciu. Analiza opierała się na modelu SIMCA, utworzonym dla sproszkowanych tabletek i zestawu próbek kalibracyjnych, przygotowanych poprzez zmieszanie nifuroksazydu ze skrobią (O do 100% wagowych nifuroksazydu). Stwierdzono występowanie zależności liniowej między główną składową PCI, obliczoną dla widm próbek kalibracyjnych w bliskiej podczerwieni a zawartością nifuroksazydu. Otrzymana w ten sposób krzywa kalibracyjna umożliwiła oznaczenie ilościowe nifuroksazydu w tabletkach farmaceutycznych. Ponadto przekształcono widma próbek kalibracyjnych w 2-gie pochodne. Wybrano kilka analitycznych długości fal, dla których wykreślono osobne krzywe kalibracyjne. Wyniki ilościowego oznaczenia nifuroksazydu w tabletkach przy użyciu tych krzywych były porównywalne z wynikami uzyskanymi metodą PCI. Obie wersje metody oznaczania nifuroksazydu w tabletkach za pomocą spektroskopii w bliskiej podczerwieni w odbiciu okazały się proste, szybkie i wystarczająco dokładne do rutynowych analiz.

16

Determination of selenium in multicomponent pharmaceutical preperations

51%

Kowalczyk P. , Łozak A. , Fijałek Z.

Chemia Analityczna

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2005

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tom Vol. 50, No. 2

437-447

EN

Adsorptive stripping voltammetry (AdSV) and inductively coupled plasma mass spectro-metry (ICP-MS) have been applied to the determination of selenium in tablets. In AdSV method a con trolled-growth mercury drop electrode (CGMDE) served as the working electrode. 0.1 mo! L-1 HClO4 solution containing 1 μg of Cu(II) per 1 mL was used as the supporting electrolyte. Optimum parameters of AdSV determination were established.Detection limit for selenium was 50 pg mL-1. The method was successfully applied to the determination of selenium in tablets: Ekovit (Curtis Healthcare) and Rutinoscorbin Plus (Glaxo Wellcome). Strong matrix effects on the determination results of selenium in pharmaceutical products have been confirmed. For this reason standard addition method was applied. The determined content of selenium in Rutinoscorbin Plus and Ekovit tablets equalled to 7.35 μg/tablet and 20.35 μ.g/tablet, respectively. Corresponding relative standard deviations were 3.70% and 3.43%, respectively. Validation of both methods was carried out. The results obtained by AdSV were compared to those obtained by ICP-MS.Mass peak of 77Se was selected to determine the selenium content by ICP-MS. The method developed in this study provides accurate and precise determination of selenium in tablets without prior isolation of the analyte from the matrix.

PL

Oznaczano selen w tabletkach stosując metodę adsorpcyjnej woltamperometrii imvcrsyjnej (AdSV) oraz spektrometrii masowej z plazmą indukcyjnie sprzężoną (ICP-MS). Se(IV) oznaczano na kroplowej elektrodzie rtęciowej o kontrolowanym wzroście powierzchni (CGMDE) w 0.1 mol L-1 roztworze HClO4 z dodatkiem l μg Cu(II) na mL. Granica wykrywalności wynosiła 50 pg mL-1;. Opracowaną metodę AdSV zastosowano do oznaczenia zawartości selenu w tabletkach (Ekovit firmy Curtis Healthcare i Rutinoscorbin Plus firmy Glaxo Wellcome) po uprzedniej ekstrakcji analitu do wody. Badania wykazały duży wpiyw matrycy na wyniki oznaczania selenu w preparatach farmaceutycznych. Oznaczona zawartość selenu w preparacie Rutinoscorbin Plus wynosiła 7.35 μ/tabletkę (RSD 3.70%), a w preparacie Ekovit 20.35 μ/tabletkę (RSD 3.43%). Przeprowadzono walidację opracowanych metod. Porównano wyniki uzyskane metodami AdSV i TCP-MS. W metodzie ICP-MS całkowitą zawartość selenu wyznaczono z piku masowego izotopu 77Se. Opracowana metodyka przygotowania próbek i badań umożliwia rurynowe oznaczanie seienu w preparatach farmaceutycznych.

17

Innowacyjne technologie w medycynie i farmacji

51%

Sarecka-Hujar B. , Ostróżka-Cieślik A. , Banyś A.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

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2016

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tom Vol. 22, nr 1

9--17

PL

Zastosowanie nowoczesnych technologii w medycynie i farmacji pozwala na coraz szybszą i skuteczniejszą diagnostykę oraz terapię wielu chorób. Do innowacyjnych należy np. drukowanie narządów, tkanek i tabletek w technologii 3D (w 2015 roku FDA zaaprobowała pierwszą drukowaną tabletkę zawierającą levetiracetam). Wyspecjalizowane roboty chirurgiczne są wykorzystywane w zabiegach chirurgicznych na odległość. Dzięki eliminowaniu drżenia rąk, ich użycie stanowi przyszłość w chirurgii i będzie coraz powszechniejsze. W poniższej pracy omówiono wykorzystanie potencjału druku 3D w medycynie i farmacji oraz zastosowania robotyki do wykonywania zabiegów chirurgicznych. Przedstawione zostały również przykłady innowacyjnych wynalazków, które mogą być stosowane podczas operacji chirurgicznych oraz w leczeniu bólu i gojeniu się ran.

EN

The use of modern technologies in medicine and pharmacy results in more rapid and effective diagnosis and treatment of many diseases. The 3D printing method is one of the innovative solutions that may be implemented for preparing organs, tissues, and solid drugs (in 2015 the FDA approved the first tablet containing levetiracetam, produced by 3DP). Specialized surgical robots are used for remote surgery. They eliminate hand tremor and their use is more and more popular. The following paper discusses the potential use of 3D printing method in medicine and pharmacy, and the application of robotics to perform surgical procedures. We also demonstrated examples of innovative devices, which can be used for surgical operations and in the treatment of pain and wound healing.