Wyniki wyszukiwania - Biblioteka Nauki

1

A study on urinary salt discharge and stomach cancer mortality

100%

Ooi E. , Natsukawa S. , Matsushima S.

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nr 2

2

Assessment of changes in body composition measured with bioelectrical impedance in patients operated for pancreatic, gastric and colorectal cancer

88%

Dzierżek P. , Kurnol K. , Hap W. , Frejlich E. , Diakun A. , Karwowski A. , Kotulski K. , Rudno-Rudzińska J. , Kielan W.

Polish Journal of Surgery

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2020

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tom 92(2)

8-11

EN

ntroduction: A proper level of nutrition is significant in the period of convalescence in patients subject to major surgical procedures, particularly due to neoplastic disease. Bioelectrical Impedance Analysis, or BIA is a widely used method in assessing body mass composition. BIA measurement is easy, quick, cheap and repetitive. Material and methods: We assessed the body composition of 56 patients (25 women and 31 men) hospitalized and operated at the Department of General and Oncological Surgery of the Wroclaw Medical University in the years 2017–2018 using bioelectric impedance. Results: The average body weight loss in the 4th postoperative day was 1.32% of body mass and on the day of release from hospital – 4.23% of body mass in relation to body mass upon admission. The percentage of body fat (FM – Fat Mass) in patients admitted to the department is above the normal range. The change in body composition in hospitalized patients mainly concerns the amount of adipose tissue and the amount of extracellular and intracellular water (ECW – Extracellular Water; ICW – Intracellular Water). Conclusions: Bioelectrical impedance can be an easy and effective method of assessing body composition and its change in patients undergoing major surgery. Amongst the analyzed groups, patients operated for pancreatic cancer lose the largest percentage of body weight until discharge from the department. Loss of body mass mainly occurs as loss of fat mass (FM).

3

Cancer procoagulant as a marker using for monitoring of oesophageal, stomach and colorectal cancer therapy

88%

Kozuszko B. , Skrzydlewska E. , Snarska J. , Kozlowski M. , Zalewski B. , Skrzydlewski Z.

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tom 39

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nr 1

4

Contribution of epidemiology in Poland for better understanding of the natural history of diseases in gastrointestinal tract

63%

Jedrychowski W.

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nr 3

245-261

EN

Descriptive epidemiologic studies on the geographical distribution of gastrointestinal diseases in Poland have been conducted in our country since several decades. One of the first descriptive analyses was cancer study in 1967, where age-standardized mortality rates in various regions of Poland by gender and area of residence (urban/rural) were presented. Since 1970 analytical epidemiologic studies aiming at explaining the natural course of various diseases within gastrointestinal tract started to produce interesting results. The first study in this field was the case-control study on the occurrence of peptic ulcer and tobacco smoking performed in 1974. The study provided one of the first epidemiologic evidence on the harmful effect of tobacco smoking in the etiology or peptic ulcers. Subsequent studies dealt with the importance of dietary habits and life style (tobacco smoking and vodka drinking) in the occurrence of gastric cancer. The studies confirmed previous findings that consumption of raw vegetables and fresh fruit is inversely related to risk for stomach cancer in Poland. In addition the results demonstrated, that dietary practices such as the modality of cooking the food, preparation of food products and storing conditions were connected with stomach cancer risk. These factors have also been found to influence the risk for stomach cancer in Poland. The main message of this latter study was that the family as a whole is affected by many risk factors for stomach cancer and families in which stomach cancer has occurred should be therefore targets for preventive measures. Interestingly, analysis of life style factors such as tobacco smoking or vodka drinking has showed that the risk for cardia cancer increased considerably for smokers of cigarettes without filters and in those who consumed large amounts of vodka. For the non-cardia region a uniform increase of risk could be observed for vodka drinking, regardless of cigarette smoking status. The findings of this study suggested the hypothesis that the effect of tobacco smoking and vodka drinking may be different for cardia cancer compared to the distal cancers. Our clinico-epidemiological study suggest that infection with Helicobacter pylori is not sufficient factor for inducing precancer changes in gastric mucosa. Besides, case-controls studies on dietary habits and physical activity level in the etiology of colorectal cancer are in progress. The preliminary results demonstrated the protective effect of higher physical activity in the occurrence of colorectal cancer after accounting for nutritional habits.

5

Usufulness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis

63%

Talar-Wojnarowska R. , Gasiorowska A. , Smolarz B. , Romanowicz-Makowska H. , Strzelczyk J. , Janiak A. , Kulig A. , Malecka-Panas E.

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nr 2

129-138

EN

The differentiation of chronic pancreatitis (CP) from pancreatic adenocarcinoma (PA) remains a great challenge. The purpose of the study was to compare the prevalence of p16 and K-ras mutation in PA and CP in order to evaluate their usefulness in differential diagnosis of those diseases. Methods: The study included 44 patients who underwent Whipple resection or distal pancreatectomy for PA (23 subjects) or CP (21 subjects). DNA from pancreatic tissue was analysed for K-ras mutation (codon 12) and p16 mutations with PCR amplifications. Results: The K-ras gene mutation has been shown in 17 (73,9%) cases with pancreatic adenocarcinoma which was significantly more often than in chronic pancreatitis - 9 (42,8%) (p<0,01). Prevalence of p16 mutations in patients with PA was 18 (78,3%) and with CP - 7 (33,3%) (p<0,01). K-ras and p16 mutations together have been observed in 16 (69,6%) cases in patients with PC and only in 3 (14,3%) - with CP (p<0,01). No statistically significant association between K-ras or p16 mutations and tumor size, sex or patient age has been observed. Conclusion: It is suggested that simultaneous measurement of K-ras and p16 mutations may provide an additional tool in differential diagnosis of chronic pancreatitis and pancreatic adenocarcinoma.

6

Stomach wall changes caused by the presence of third-stage Anisakis simplex B larvae in infected dogs

51%

Podolska M. , Piusinski W. , Rokicki J.

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tom 42

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nr 4

EN

Samples of stomach fundus and pylorus tissue collected from eight dogs experimentally infected with third-stage A. simplex В larvae were examined macro- and microscopically. The histopathological changes in these samples were analysed. Pathomorphological examination revealed that A. simplex В larvae actively penetrated the dog’s stomach wall within 2 days of infection. The presence of larvae in the mucous membrane was accompanied by tissue damage and cell infiltration predominantly by eosinophils.