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Analiza porównawcza wpływu dwóch form antagonisty receptora glutaminianergicznego (mGluR) grupy I na stężenie katecholamin w ostrym bólu jelitowym u owcy

100%

Kania B. F. , Wronska D.

Medycyna Weterynaryjna

2015

tom 71

nr 08

The aim of this study was a comparative analysis between a five minute episode of mechanical colonal descending distension, which was provoked by the insertion of a balloon filled with 200 ml of water (CD200), and plasma CA concentration (epinephrine E, norepinephrine – NE and dopamine – DA) changes as a consequence of the sympatho-medullary-adrenal axis stimulation as well as nociceptive/stressoric effects. Furthermore, to note the comparative influence of premedication by metabotropic glutamate receptor antagonists by L-isomer (L-AP3) in the doses of 0.2, 0.4 and/or 0.8mg in toto and/or DL-AP3 racemate i.c.v. one min infusion in three different doses (4.0, 8.0 or 12.0 mg in toto) on the plasma CA concentration changes during 120 min of experimentation. The experiment was carried out in four series using 12 female sheep, Polish Merinos, in the anoestrus period (May–June). In the first series (six animals as a control group) the animals had a 200 μl 0.9% NaCl i.c.v. infusion. In the second series (six animals) they had a five min episode of CD by insertion of a balloon filled with 200 ml of water (CD200). In the third series of the experiment six animals had an i.c.v. DL-AP3 or L-AP3 infusion in three different doses (4.0, 8.0 or 12.0 and 0.2, 0.4 or 0.8 mg in toto, respectively), while in the fourth series, ten minutes before CD200, every week. Colon descending distension episodes lasting five min provoke a very repetitive, statistically significant increase of plasma CA concentration, a critical indicator – after cortisol – of the consequent stressoric effect of the sympatho-medullary adrenal axis stimulation. As a metabotropic nonspecific glutamate receptor type-1 antagonists DL-AP3 racemate and L-isomer AP3 certainly attenuate this elevation of CA, and can be an alternative drug in colonal pain caused by their wall having been distended in sheep. Clinical application of this AP3 must be confirmed by peripheral administration of the drugs.

Wplyw rozszerzania dwunastnicy na aktywnosc ukladu wspolczulno-rdzeniowo-nadnerczowego u owcy

88%

Kania B. F. , Wronska-Fortuna D. , Majcher A.

Medycyna Weterynaryjna

2003

tom 59

nr 04

335-338