Wyniki wyszukiwania - Biblioteka Nauki

1

Kwasy żółciowe jako komponenty architektoniczne w chemii supramolekularnej

100%

Łotowski Z.

Wiadomości Chemiczne

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2003

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tom [Z] 57, 11-12

1093--1132

EN

One of the most important fields in modern synthetic chemistry is the preparation of molecules which can recognize and bind others and then catalyze transformations of the bound molecules i.e. „artificial enzymes”, and the construction of systems which can reproduce themselves or otherwise store and process information at the molecular level [5 ? 8]. The above mentioned properties of these novel synthetic structures will result not only from the presence therein of the various required elements, but also from their relative arrangements in space and the three-dimensional shape of the overall assembly. In other words, spatially separated elements combine to achieve an overall effect in these structures. Hence, there will be a requirement for molecules with well-defined geometries in which conformational freedom is kept under close control. This criterion can be met by designs based on rigid frameworks. The steroid nucleus is one of the largest rigid units which is readily available. There are many steroidal compounds which might be chosen as starting materials for more elaborate frameworks. However, bile acids are the most valuable group of these compounds due to their chemically different hydroxyl groups, enantiomeric purity, unique amphiphilicity, availability and low cost. Bile acids are natural polyhydroxylated steroidal acids existing in bile as sodium salts of N-acyl derivatives of glycine and taurine. They are synthesized from cholesterol and can solubilize hydrophobic substances by the formation of micellar aggregates and thus help in the digestion of fat lipids. In this review applications of bile acids as building blocks in the synthesis of macrocyclic and also open-chained supramolecular hosts are presented.

2

Opioid antagonist and agonist effects on GnRH release in vitro from the SME of ovariectomized gilts primed with steroids

99%

Okrasa S. , Kalamarz H.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

3

Phytopharmacological study of red, white and black variety of Abrus precatorius L.

71%

Garaniya N. H. , Bapodra A. H. , Ladva K. D.

International Letters of Natural Sciences

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2014

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tom 09

EN

Abrus precatorius L. is a leguminous plant of family fabaceae. Plant parts are widely used for medicinal purpose in different region of the world. Seed behavior and phytochemical evaluation of different solvent extracts (i.e. Petroleum ether, Ethyl acetate, Methanol & Water) of leaf and seed of red, white and black varieties of Abrus precatorius L. is carried out in the present study. This study indicates presence of different phytoconstituents i.e. alkaloids, steroids, glycosides, proteins, etc. the present study concludes that the plant parts can be used as very good natural remedy to diagnosed variety of dieses.

4

Molecular basis of mechanisms of steroid resistance in children with nephrotic syndrome

71%

Swierczewska M. , Ostalska-Nowicka D. , Kempisty B. , Nowicki M. , Zabel M.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

EN

Steroid therapy, due to a wide range of anti-inflammatory properties of steroids, is a basic field of treatment in many human diseases including the nephrotic syndrome in children. However, not all patients respond positively to therapy which divides them into steroid sensitive (SS) and steroid resistance (SR) individuals. Many potential factors associated with steroid resistance have been identified so far. It seems that genetic factors associated with glucocorticoid receptor α (GRα), the structure of heterocomplex of GR as well as glycoprotein P or cytochrome P450 may play a role in the induction of glucocorticoid resistance. Here we described several of the molecular mechanisms, which can regulate glucocorticoid sensitivity and resistance. Moreover, we presented genetic defects, which can lead to various effects of treatment and, in a longer perspective, enable clinicians to individualize therapies.

5

Mammalian sex hormones in plants

71%

Janeczko A. , Skoczowski A.

Folia Histochemica et Cytobiologica

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2005

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tom 43

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nr 2

6

Non-genomic effect of ovarian steroids on oxytocin-stimulated prostaglandin [PG] F2alpha and E2 secretion from bovine endometrial cells

71%

Kowalik M. , Kotwica J.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 1

EN

The aim of the study was to establish the effect of the ovarian steroids: 17β-oestradiol (E2) and testosterone (T4) on OT-stimulated PGF2α and PGE2 secretion by bovine endometrial cells. The epithelial endometrial cells from days 14-18 of the oestrous cycle (10⁵/ml) were incubated in DMEM/Ham's F12 with 10% FCS (38°C, atmosphere of air and 5% CO₂) for 72-96 h and the last 24 h in DMEM/Ham's F12 with 0.1% BSA. In Exp.l, the doses of steroids used to study their effect on the secretion of PGF2α and PGE2 from endometrial cells stimulated by OT were determined. In Exp.2, the cells were pre-incubated for 30 min with selected doses of steroids: P4 (10⁻⁵ M), T4 (10⁻⁵ M), and E2 (10⁻⁸ M) and next for 4 d with: arachidonic acid (AA; 10⁻⁵ M), OT (10⁻⁷ M) and OT with each of these steroids. The concentration of PGE2 and PGFM -metabolite of PGF2α was determined by EIA. P4, T4, and E2 did not affect (P>0.05) the basal secretion of PGF2α and PGE2, but all the steroids inhibited (P<0.01) OT- stimulated PGF2α secretion. The stimulating effect of OT on PGE2 secretion was not affected by P4 and T4 (P>0.05). This data suggests that different cellular mechanisms exist for steroids affecting the secretion of both prostaglandins from endometrial cells. Moreover, we suggest that non-genomic effect of P4 on bovine endometrial cells is non-specific since the other steroids can impair the effect of OT on these cells. This effect of the steroids can directly modulate function of endometrial cells.

7

Eosinophil cationic protein in serum of corticosteroid-sensitive and resistant bronchial asthma

71%

Patkowski J. , Wytrychowski K. , Medrala W.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 2-3

8

Polychlorinated biphenyls impair FSH - stimulated effect on the secretion of steroids and oxytocin from cultured bovine granulosa cells

71%

Mlynarczuk J. J. , Niewiadowska A. , Kotwica J.

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nr 4

9

Evaluation of changes in the growth and chemical constituents of Anoectochilus formosanus Hayata grown under hydroponic conditions

57%

Nguyen H. C. , Nhu T. Q. M. , Dung P. V. , Hieu N. D. , Tuan T. T. , Huyen P. X. , Truong D.-H.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2018

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tom 99

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nr 4

10

The influence of steroids on the vascular tension of isolated superficial nasal and facial veins in gilts during sexual maturation

57%

Grzegorzewski W. J. , Muszak J. , Tabecka-Lonczynska A. , Stefanczyk-Krzymowska S.

Polish Journal of Veterinary Sciences

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2010

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tom 13

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nr 2

11

Influence of progesterone, pregnenolone and 17beta-hydroxyprogesterone on the function of bovine luteal cells treated with luteinizing hormone, noradrenaline and prostaglandin E2

57%

Duras M. , Brzosko E. , Kotwica J.

Polish Journal of Veterinary Sciences

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2005

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tom 08

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nr 2

12

In vitro effects of luteinizing hormone, progesterone and oestradiol-17beta on leptin gene expression and leptin secretion by porcine luteal cells obtained in early pregnancy

57%

Siawrys G. , Smolinska N.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 4

13

The effect of prophylactic doses of nadroparin and therapeutic doses of betamethasone on skin flap survival in rats

57%

Bielecki M. , Karpik M. , Skowronski J.

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2009

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tom 47

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nr 4

14

Local retrograde and destination transfer of physiological regulators as an important regulatory system and its role. Facts and hypothesis

57%

Krzymowski T. , Stefanczyk-Krzymowska S.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 1

15

Correlation between Helicobacter pylori infection and pulmonary Wegener's granulomatosis activity

57%

Zycinska K. , Wardyn K. A. , Zycinski Z. , Smolarczyk R.

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nr 6

845-851

16

SOCS3 and SOCS5 mRNA expressions may predict initial steroid response in nephrotic syndrome children

57%

Ostalska-Nowicka D. , Smiech M. , Jaroniec M. , Zaorska K. , Zawierucha P. , Szaflarski W. , Malinska A. , Nowicki M.

Folia Histochemica et Cytobiologica

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2011

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tom 49

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nr 4

17

Increased serum osteoprotegerin in patients with primary adrenal insufficiency receiving conventional hydrocortisone substitution

57%

Fichna M. , Zurawek M. , Fichna P. , Gryczynska M. , Nowak J. , Ruchala M.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 6

18

Biosynthesis of gonadotropins in vivo

57%

Kochman K. , Gajewska A.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 3

19

Monoclonal antibody analysis of glomerular and renal interstitial immune cells in steroid-resistant and steroid-responsive minimal change disease in children

57%

Wagrowska-Danilewicz M. , Danilewicz M.

Archivum Immunologiae et Therapiae Experimentalis

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1996

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tom 44

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nr 2-3

20

The effect of steroids and their complexes with cyclodextrins on secretory activity of cultured thyroid medullary carcinoma cells

57%

Grzeszkowiak J. , Seidel J. , Zabel M.

Folia Histochemica et Cytobiologica. Supplement

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1996

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tom 34

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nr 1