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EN
The severity of fat in ultrasonic liver images is quantified based on characteristics of three regions in the image namely diaphragm, periportal veins and texture of liver parenchyma. The characteristics of these regions vary with the severity of fat in the liver, and is subjected to low signal to noise ratio, low contrast, poorly defined organ boundaries, etc., hence locating these regions in ultrasound images is challenging task for the sonographers. Automated detection of these regions will help the sonographers to do accurate diagnosis in shorter time, and also acts as a fundamental step to develop automated diagnostic algorithms. In this paper, we propose a novel multi-modal framework for detecting diaphragm, periportal veins and texture of liver parenchyma in ultrasonic liver ultrasound images. Since the characteristics of these regions differ from each other, we propose a specific algorithm for detecting each region. Diaphragm and periportal veins are detected with the combination of Viola Jones and GIST descriptor based classifier, while homogeneous texture regions are detected with the combination of histogram features based classifier and connected components algorithm. The proposed algorithm when tested on 180 ultrasound liver images, detected the diaphragm, periportal veins and texture regions with an accuracy of 97%, 91% and 100% respectively.
EN
Our study with animal models was designed to test the hypothesis that green tea protects against chronic (over 4 weeks) alcohol induced liver injury in rats. The research was conducted on Wistar male rats divided into 4 research groups: I — received the Libera-De Carli control diet (L-DC), II — received (L-DC) and green tea, III — received (L-DC) and ethanol and IV — received (L-DC), green tea and ethanol. When comparing groups I and II we saw less intensive steatosis in group II than in group I, which can suggest that green tea may affect the accumulation of fat in the hepatocytes and protect them against steatosis and disruption. In III, the ethanol group, the steatosis of the liver increased considerably and the green tea which was given with ethanol in group IV did not halt this, as in group IV we also observed intensive steatosis in the liver. From this data we conclude that green tea has an important, although not fully understood role in preventing liver injury.
EN
Significantly decreased amounts of carbohydrates and increase of fat in diet (Atkins’ diet, Jan Kwaœniewski’s diet) may interfere with liver metabolism because main source of liver energy are carbohydrates. Large amount of fatty acid in diet may induce overproduction of reactive oxygen species in mitochondria because of increased oxidation and may cause steatosis. The influence of high-fat, low-carbohydrate diet (contained 14 g% protein, 25 g% fat, 8 g% carbohydrate) and compared to usual habitual diet (13 g% protein, 3 g% fat, 28 g% carbohydrate) as a control on liver function was examined in adult male rabbits. Fodder and water was ad libitum. The experiment lasted 24 weeks. At the beginning and every six weeks rabbits were weighed and blood was taken. Plasma glucose and cholesterol concentration, activity of glutamate dehydrogenase, alanine and aspartate in plasma and liver did not change. Concentrations of triacylglycerols (TG) in plasma were lower in the study group. Activity of aldolase increased in plasma and in liver in the study group while activity of sorbite dehydrogenase decreased in plasma at the end of the experiment. Malondialdehyde (MDA) concentration increased in aorta with no changes in liver and erythrocytes. Activity of glutathione peroxidase increased in erythrocytes and liver while total SOD increased only in the liver. High-fat, low-carbohydrate diet despite the lack of growth of the body mass, modifies significantly the homeostasis of carbohydrates and antioxidants in liver and enhanced production of TG in this organ, resulting in its steatosis.
EN
Chronic hepatitis B and C are among the most common liver diseases. A prolonged necroinflammatory process may lead to life-threatening complications although in some cases the liver condition remains stable for many years. Due to its unpredictable prognosis, a great deal of research has been carried out to find additional factors that modify the course of these diseases. Adipocytokines, substances secreted mainly by adipose tissue cells, have become the object of various studies due to their pluripotent impact. This paper aims to present the interrelationship of selected adipo-cytokines and hepatitis B and C, as well as the potential use of this knowledge in medical practice.
PL
Przewlekłe wirusowe zapalenie wątroby (WZW) typu B i C należą do najczęstszych chorób wątroby. Długotrwały proces martwiczo-zapalny może prowadzić do groźnych dla życia powikłań, choć u niektórych pacjentów stan wątroby jest stabilny przez wiele lat. Ze względu na zróżnicowane rokowanie w przebiegu przewlekłego wirusowego zapalenia wątroby (PWZW) typu B i C, poszukuje się obecnie dodatkowych czynników hamujących postęp tych chorób. Obiektem wielu badań stały się adipocytokiny, substancje o wielokierunkowym oddziaływaniu, wytwarzane m.in. przez komórki tkanki tłuszczowej. W pracy przedstawiono wzajemne zależności wybranych adipocytokin i WZW typu B i C oraz potencjalne wykorzystanie tej wiedzy w praktyce lekarskiej.
9
Content available remote Biological role of liver X receptors
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tom 59
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nr 7
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Content available remote Therapy of nonalcoholic fatty liver disease: current status
51%
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