Wyniki wyszukiwania - Biblioteka Nauki

1

Universality of Splicing Test Tube Systems with Two Tubes

100%

Verlan S. , Margenstern M.

Fundamenta Informaticae

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2011

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tom Vol. 110, nr 1-4

329-342

EN

Splicing test tube systems are one of the first distributed computing models based on splicing. The model introduces (test) tubes where the splicing operation is applied, which are arranged in a communication network with filters that permits to redistribute the words between the tubes at each step. We show that the computational completeness can be achieved with two tubes when the communication graph does not have self-loops. We also construct a universal splicing test tube system with 2 tubes having 23 rules.

2

Methodology of splicing large air filling factor suspended core photonic crystal fibres

100%

Jaroszewicz L. R. , Murawski M. , Nasilowski T. , Stasiewicz K. , Marć P. , Szymański M. , Mergo P.

Opto-Electronics Review

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2011

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tom Vol. 19, No. 2

256-259

EN

We report the methodology of effective low-loss fusion splicing a photonic crystal fibre (PCF) to itself as well as to a standard single mode fibre (SMF). Distinctly from other papers in this area, we report on the results for splicing suspended core (SC) PCF having tiny core and non-Gaussian shape of guided beam. We show that studied splices exhibit transmission losses strongly dispersive and non-reciprocal in view of light propagation direction. Achieved splicing losses, defined as larger decrease in transmitted optical power comparing both propagation directions, are equal to 2.71 ±0.25 dB, 1.55 ±0.25 dB at 1550 nm for fibre SC PCF spliced to itself and to SMF, respectively.

3

A Direct Construction of a Universal P System

100%

Frisco P. , Hoogeboom H. J. , Sant P.

Fundamenta Informaticae

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2002

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tom Vol. 49, nr 1-3

103-122

EN

We present a direct universal P system based on splicing. Our approach differs from those shown in previous papers as the P system we construct takes as input an encoding of another P system. Previous results were based on the simulation of universal type-0 grammars or Turing machines. We think that the approach we use can be applied to other variants of P systems.

4

Alternative 3' acceptor site in the exon 2 of human PAX8 gene resulting in the expression of unknown mRNA variant found in thyroid hemiagenesis and some types of cancers

100%

Szczepanek-Parulska E. , Szaflarski W. , Piątek K. , Budny B. , Jaszczyńska-Nowinka K. , Biczysko M. , Wierzbicki T. , Skrobisz J. , Zabel M. , Ruchała M.

Acta Biochimica Polonica

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2013

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tom 60

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nr 4

573-578

EN

PAX8 gene encodes one of the transcription factors engaged in the regulation of proper development of thyroid gland as well as Müllerian and renal/upper urinary tracts. So far, six alternatively spliced transcripts were reported, however, sequences of only four were deposited in the NCBI database. Here, we evaluate a fragment of a novel variant of PAX8 mRNA formed by an alternative 3' acceptor site located in the second exon. The molecular outcome encompasses extension of the 5' untranslated region of exon two by 97 nucleotides as is evident from mRNA. This new insert may impair binding of mRNA to the ribosome and in consequence significantly decrease expression of the PAX8 protein. Here, we show for the first time that the novel insert in exon two might be associated with congenital thyroid hemiagenesis and influence development of different types of cancer.

5

An Algebraic Characterization of Semi-Simple Splicing

100%

Ceterchi R.

Fundamenta Informaticae

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2006

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tom Vol. 73, nr 1-2

19-25

EN

An algebraic characterization of simple splicing languages given in [6] is extended to semi-simple splicing languages

6

Time-Varying Distributed H Systems: An Overview

100%

Margenstern M. , Verlan S. , Rogozhin Y.

Fundamenta Informaticae

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2005

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tom Vol. 64, nr 1-4

291-306

EN

Time-varying distributed H systems are a well known model of molecular computing. In this article we present an overview of this model, its history, related results, and open problems.

7

Butt welding of round drive belts

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Wałęsa K. , Malujda I. , Talaśka K.

Acta Mechanica et Automatica

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2018

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tom Vol. 12, no. 2

115--126

EN

The on-going rapid development of industry encourages development of new production technologies and designing of machines that use inventive mechanical engineering solutions, a big demand for parts of such machines being a natural consequence. Polymeric power transmission belts are a good example of that. This paper proposes an improvement in the process of production of such belting. Their production includes cutting to length and splicing of elastic round belts to obtain endless belts of the specified length. This is the key phase of the whole production process. A number of splicing methods are available using different physical phenomena. One of them is butt welding technique. In this process heat is applied on the material through an additional heating element called the heat platen. The effect depends on several factors, including preparation of the work pieces. Due to its characteristics the process is often carried out by hand. The need for automated manufacturing was created by important factors associated with manufacturing on an industrial scale: cost, time and quality. The proposed butt welding machine, complete with a control system is an answer to this need. The practical benefits include improved repeatability of splices, time savings and less work load for the operator.

8

Składniki spliceosomu jako cel terapii przeciwnowotworowych

89%

Rokosz K.

Edukacja Biologiczna i Środowiskowa

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2013

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nr 4

11-16

PL

Splicing jest katalizowany przez spliceosom – duży kompleks białek i RNA, składający się z pięciu małych jądrowych nukleoprotein (snRNP). Rekrutacja białek do spliceosomu jest procesem dynamicznym i angażującym wiele czynników. Reakcje splicingu mogą spełniać istotną rolę podczas kancerogenezy. Nowo odkryte dwie struktury chemiczne naturalnego pochodzenia, skierowane przeciw spliceosomom, wykazały potencjał przeciwnowotworowy. Obydwie te substancje, pladienolid i spliceostatyna A wiążą się do SF3b – podjednostki U2 snRNP, kluczowego składnika spliceosomu. Ostatnie doniesienia na temat substancji skierowanych przeciw spliceosomom i wykazujących aktywność przeciwnowotworową stwarzają nowe możliwości terapeutyczne.

EN

Splicing is catalyzed by the spliceosome, which is a large RNA-protein complex composed of five small nuclear ribonucleoproteins (snRNP). Spliceosome assembly is a highly dynamic process in which a number of factors is involved. Splicing reactions may play an vital role in cancerogenesis. Recently, two chemically different microbial natural products with cancer cell inhibiting potential were found to target the spliceosome. Both compounds, the pladienolide derivatives and spliceostatin A appear to bind to SF3b, a subcomplex of U2 snRNP, which is an essential part of spliceosome. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.

9

Recognition of the 5' splice site by the spliceosome

75%

Konarska M. M.

Acta Biochimica Polonica

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1998

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tom 45

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nr 4

EN

The splicing of nuclear pre-mRNAs is catalyzed by a large, multicomponent ribonucleoprotein complex termed the spliceosome. Elucidation of the molecular mechanism of splicing identified small nuclear RNAs (snRNAs) as important components of the spliceosome, which, by analogy to the self-splicing group II introns, are implicated in formation of the catalytic center. In particular, the 5' splice site (5'SS) and the branch site, which represent the two substrates for the first step of splicing, are first recognized by U1 and U2 snRNPs, respectively. This initial recognition of splice sites is responsible for the global definition of exons and introns, and represents the primary target for regulation of splicing. Subsequently, pairing interaction between the 5'SS and U1 snRNA is disrupted and replaced by a new interaction of the 5'SS with U6 snRNA. The 5'SS signal contains an invariant GU dinucleotide present at the 5' end of nearly all known introns, however, the mechanism by which the spliceosome recognizes this element is not known. We have identified and characterized a specific UV light-induced crosslink formed between the 5'SS RNA and hPrp8, a protein component of U5 snRNP in the spliceosome that is likely to reflect a specific recognition of the GU dinucleotide for splicing. Because recognition of the 5'SS must be linked to formation of the catalytic site, the identification of a specific and direct interaction between the 5'SS and Prp8 has significant implications for the role of this protein in the mechanism of mRNA splicing.

10

The crosstalk between splicing of protein-coding genes and processing of microRNAs located within their introns

63%

Skorupa K. , Sobkowiak L. , Jarmolowski A. , Szweykowska-Kulinska Z.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 3

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