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1 Acta Biochimica Polonica

1 1995

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EF-1alpha is a target site for inhibitory effect of quercetin in the peptide elongation process

100%

Marcinkiewicz C. , Galasinski W. , Gindzienski A.

tom 42

nr 3

The effect of quercetin (3,3',4',5,7-pentahydroxyflavone) on the polypeptide elongation system isolated from rat liver cells, was investigated. Quercetin inhibited [ 4C]leucine incorporation into proteins in vitro and the inhibitory effect is being directed towards the elongation factor eEF-1, but not to eEF-2 and ribosomes. Quercetin was found to form a complex with EF-la, which was inactive in GTP-dependent binding to ribosomes. It can be suggested that quercetin can block the total or the part of the domain of EF-la structure that is responsible for formation of the ternary complex EF-la-GTP-i14C]Phe-tRNA and therefore preventing formation of the quaternary complex with ribosomes.