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Dissociation between the effects of P1,P4-diadenosine tetraphosphate (Ap4A) on renal haemodynamics and tubular function in anaesthetized rats

100%

Jankowski M. , Angielski S. , Szczepanska-Konkel M.

tom 59

nr 1

Previous studies from our laboratory have reported a marked reduction in glomerular filtration rate (GFR) and sodium reabsorption in renal proximal tubule during intravenous infusion of P1,P4-diadenosine tetraphosphate (Ap4A) at dose of 1.0 µmol/kg + 10 nmol/kg/min (i.v., injection followed by infusion) in anaesthetized Wistar rats. In the present study, the changes of GFR and urine sodium excretion were investigated in response to systemic infusion of Ap4A at different doses. Ap4A at dose of 0.1 µmol/kg + 1.0 nmol/kg/min did not change GFR and sodium urinary excretion whereas 2-fold higher dose produced significant (3.4-fold) increase in sodium excretion without changes in GFR. Significant but transient reduction in GFR by ~21% was observed during infusion of Ap4A at dose of 0.5 µmol/kg + 5.0 nmol/kg/min. Higher doses of Ap4A (1.0 µmol/kg + 10 nmol/kg/min and 2.0 µmol/kg + 20 nmol/kg/min) produced sustained reduction in GFR and marked natriuresis. Our results suggest that tubular sodium transport systems are more sensitive to Ap4A than systems involved in GFR regulation.

The mechanism of Naplus, Kplus -ATPase inhibition by atrial natriuretic factor in rat renal medulla

80%

Beltowski J. , Gorny D. , Marciniak A.

Journal of Physiology and Pharmacology

1998

tom 49

nr 2