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2 Bromatologia i Chemia Toksykologiczna

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Badania porownawcze toksycznosci roztworow fenylofenolanu sodowego. Cz.I. Toksycznosc ostra dozoladkowa

100%

Mlynarczyk W. , Adamska T. , Sadowski C. , Wachowiak A. , Ewertowska M. , Senczuk W.

nr 2

207-211

Dokonano oceny porównawczej toksyczności ostrej 1,5 i 2,0% wodnych roztworów fenylofenolanu sodowego stosowanych do impregnacji drewna.

The potencies of the toxic activity of 1.5% and 2% aqueous sodium phenylphenolate solutions prepared from the commercial product containing 59.4% of that compound were compared. The acute oral toxicity was tested by Gaddum's Probit Analysis using male Wistar rats. Significant differences between median lethal volumes determined for the test solutions were observed. The potency of the toxic activity of the 2% aqueous solution was found to be 1.9 times higher than that of the 1.5% sodium phenylphenolate solution. However, the regression coefficients of the log-probit lines did not differ significantly, which indicates that the difference between the toxic activities of the two test solutions were not significant. Median lethal doses for both test solutions allow to classify them as weak toxicants.

Badania porownawcze toksycznosci roztworow fenylofenolanu sodowego. Cz.II. Wskazniki kumulacji czynnosciowej

80%

Mlynarczyk W. , Ewertowska M.

nr 1

29-33

Dokonano oceny porównawczej toksyczności 1,5 i 2,0% roztworów wodnych sporządzonych z produktu technicznego zawierającego 59,4% fenylofenolanu sodowego.

Functional accumulation coefficients for 1.5% and 2.0% aqueous solutions of commercial sodium phenylphenolate (used for wood impregnation) were determined on male Wistar rats by the Lim method. Hematological and histopathological examinations were also performed. The cumulative median lethal volumes for the 1.5% and 2.0% solutions determined in our experiment were 98.7 cm3/kg/d and 76.0 cm3/kg/d, respectively. The calculated cumulative coefficients (Kk 1.5% 0.55; Kk2.0% 0,75) and degree of accumulation (Sk 1.5% 181%; Sk 2.0% 126%) point to the cumulative properties of the examined solutions. The symptoms of poisoning: changes in body weight increase and foodstuff intake; morphological changes of spleen and upper airways mucosa; shifts in white blood cell composition observed in our experiment support the toxic and cumulative character of the examined solutions.