Wyniki wyszukiwania - Biblioteka Nauki

1

Effect of a high amino acid diet on antioxidant barrier parameters of rat skin.

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Niczyporuk M. , Knaś M. , Grądzka K. , Car H.

Progress in Health Sciences

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2019

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tom 1

45-50

EN

Introduction: Oxidative stress is largely responsible for numerous skin complications that occur in the course of various diseases as well as accelerated skin aging. A high amino acid diet, supplemented with whey protein concentrate (WPC), is well-balanced and has well-absorbing proteins, which are an ideal source of essential amino acids. Purpose: To assess what changes will occur in the antioxidant barrier of unharmed skin of rats on a high amino acid diet. Materials and methods: The study was conducted on sexually mature male Wistar rats (160-180g): 1. control (standard feed), 2. high amino acid diet (WPC-80 80% whey protein) administered for 7 days at a dose of 0.3g/kg of body weight, 3. WPC-80 for 7 days at a dose of 0.5g/kg of body weight, 4. WPC-80 for 14 days at a dose of 0.3g/kg of body weight, 5. WPC-80 for 14 days at a dose of 0.5g/kg of body weight. Total antioxidant capacity, total oxidative status and oxidative stress index were determined. Results: Enrichment of a standard diet with WPC-80 did not affect the total oxidative status of undamaged healthy rat skin. This study shows that a diet rich in amino acids in rats caused an increase in total antioxidant capacity, but statistically significant values were obtained after 14 days of administering WPC at a dose of 0.5mg/kg of body weight. Conclusions: Enrichment of a standard diet with WPC-80 strengthens the antioxidant barrier in unwounded healthy rat skin.

2

Effect of a high amino acid diet on antioxidant barrier parameters of rat skin. Part 2

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Knaś M. , Niczyporuk M. , Grądzka K. , Car H.

Progress in Health Sciences

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2019

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tom 1

70-75

EN

Purpose: The imbalance between the formation of reactive oxygen species and antioxidant capacity of the body is known as oxidative stress. Exposition of the skin to free radicals, the origin of the internal and external causes activation of multiple mechanisms to eliminate them and prevent in this way the development of oxidative stress. The aim of this experiment was examining what changes are taking place in the antioxidant barrier of unwounded healthy skin of rats, who are on a high amino acids diet for 7 and 14 days at administered doses of 0.3 and 0.5 g/kg body weight. Materials and Methods: The study was performed on male Wistar rats divided into 5 groups: 1. control (standard feed), 2. high amino acid diet (WPC-80 80% whey protein) administered for 7 days at a dose of 0.3g/kg of body weight, 3. WPC-80 for 7 days at a dose of 0.5g/kg of body weight, 4. WPC-80 for 14 days at a dose of 0.3g/kg of body weight, 5. WPC-80 for 14 days at a dose of 0.5g/kg of body weight. The concentration of superoxide dismutase 2 and 3, the concentration of catalase specific activity of glutathione peroxidase, the concentration of glutathione and total protein content were determined. Results: The supplementation of the standard diet by the preparation of WPC-80 administered in a dose 0.5 g/kg body weight for 14 days containing methionine and cysteine (essential amino acids involved in the formation of glutathione), significantly increases the concentration of reduced glutathione. Conclusions: Enrichment of a standard diet with WPC-80 caused by the significant increases of non-enzymatic antioxidant.

3

Dermatologia malarska. Obraz skóry a skóra obrazu

100%

Smolińska M.

Artium Quaestiones

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2016

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nr 27

129-169

PL

Since the 1990s, the motif of mimetically reproduced human skin, concentrating the recipient’s attention on the sense of touch and on the surface which separates theinside from the outside, seems to have been more and more popular. It has been quite ostentatiously exposed in the works of such well-known artists as Ron Mueck, Patricia Piccinini, Pipilotti Rist, John Isaacs, and Nicole Tran Ba Vang, becoming anemblem of the present. The paradox is, however – and this is one of the claims formulated in the present essay – that the motif’s most complex versions do not appear in photography, installations or the new media, but in easel painting which has been often dismissed as inadequate to new ideas. To provide evidence – the paintings of Magdalena Moskwa, Bartosz Kokosiński, Paweł Matyszewski, Grzegorz Sztwiertnia, Saskia de Kleijn, and Marina Schulze – the author has distinguished the so-called painterly dermatology. The present time, which offers no striking generational manifestoes or dominant artistic currents, has brought us a revealing metaphor coined by Yuri Lotman who compares the activity of artists to the dissociated energy of a minefield where we can here random explosions but it is impossible to predict if and where they will actually take place. Thus, it is the author’s contention that the painterly dermatology can be perceived as one of such explosions – they can be distinctly “heard” on the contemporary global art stage and included as a singular phenomenon in a broader tendency connected to the exploration of the body in the era of media convergence. The selected artists, who have identified the motif of skin with the surface of a painting, have a initiated tension between the transformation of the body into the body of art, which is significantly close to the tradition of religious painting, and the transposition of the human skin into the skin of a painting, which stresses a metapainterly aspect and a dialog with the potential of the medium. The complexity of the painterly dermatology inaugurates a narrative which runs across not only of modernism and postmodernism, but also a centuries-old artistic tradition. Moreover, skin as a limit phenomenon is situated between the inside and the outside, putting this dualistic division into doubt. As a topic, it is both archaic and contemporary. Also, it should not be forgotten that the growing interest in the motif of skin is taking place in the context of changes of the hierarchy of the senses, downgrading sight in favor of touch and the tactile qualities of art which activate the sensomotoric and soma esthetic perception. After all, the sense of touch has always been located in the skin. Referring to Geoges Didi-Huberman, Hans Belting, and David Freedberg’s anthropology of painting as well as to Vilém Flusser’s extended philosophical dermatology, the author suggests that the easel painting provides the ground for the most complex artistic experiments in which the medium continues its self-critical work, being continuously reinvented, even though it does not remain as pure as Clement Greenberg wanted it to be. The question of the “painterly dermatology” corresponds to a claim of Rosalind Krauss that the “post-media era” does not dismiss the problem of the medium but readdresses it in a polemical context. The medium in the paintings of Moskwa, Matyszewski, Kokosiński, Sztwiertnia, de Kleijn, and Schulze, in which the picture of the skin is also the skin of the picture, has been defined in the essay as a network of conventions which determines a zone mediating between the material stratum of the painting and its aesthetic qualities, initiating critical and differentiating dialogs with the received tradition.

4

Malignant mixed tumor of the skin: a case report and review of the literature

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Famulski W. , Kańczuga- Koda L. , Niewiarowska K. , Niksa M. , Maruszak K. , Koda M. , Pryczynicz A.

Progress in Health Sciences

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2013

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tom 3

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nr 1

154-158

EN

Introduction: Malignant mixed tumor (MMT) is an exceedingly rare cutaneous adnexal carcinoma with a significant risk for aggressive behavior and a propensity for metastasis. This tumor occurs in a wide age range and is twice as common in woman than in men. MMT shows a predilection for the trunk and the extremist’s foremost hands and feet. MMT may be confused clinically with many benign and malignant lesions. Therefore the histopathological and immunohistochemical examination is required for the correct diagnosis and treatment. Purpose: To present a case of MMT localized in the left toe with a special attention focused on its histopathology and differential diagnosis. Case presentation: A 56-year-old female was admitted with a nodular lesion on the left toe. A painless mass had been presented for one year with a significant increase in size within the past three month. The patient underwent wide surgical excision. Histopathologically for the lesion was diagnosed it as a malignant mixed tumor. Immunohistochemical examination revealed positive reaction for cytokeratin AE1/AE3/PCK26, vimentin and S-100. Histochemical reaction for PAS in the chondromyxoid tumor stroma was negative. Conclusion: Correct histopathological diagnosis and complete excision with wide disease-free margins before metastasis result in MMT free survival.

5

Rat skin as an experimental model in medicine

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Niczyporuk M.

Progress in Health Sciences

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2018

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tom 8(2)

223-228

EN

Scientific experiments due to safety and ethical limitations regarding research human are often based on animal models. Rats are laboratory animals which are commonly used for these purposes. It should be remembered that morphologi- cal and functional differences between rat skin and human skin may refer to the correct interpretation of scientific results.

6

The influence of an opioid on the course of reparative processes

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Mateshuk-Vatseba L. , Diskovskyi I.

Current Issues in Pharmacy and Medical Sciences

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2015

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tom 28

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nr 1

46-50

EN

The objective of our work is to examine the influence of prolonged administration of an opioid, on the course of the reparative process of a multiple post-injection wound inflicted upon a white rat’s skin, doing so by way of using light microscopy. The studies were carried out on 24 mature white male rats, aged 4.5-7.5 months, with weights of 130-150 g. For histological examination, the skin sections were stained with hematoxylin and eosin. The preparations were studied and photographed at the magnification of ob.х8, ey.x15 and ob.x40, ey.x10. The «Aver Media» computer system was employed for micropreparations photography. The set levels of light microscopy reveal that the administration of an opioid for a 2 week period does not affect the reparative process of a multiple post-injection wound. Moreover, in most wound canals, the formation of a complete regenerate can be seen. However, after 4 weeks of nalbufin administration, the processes of wound healing slowed and were complicated by the formation of microabscesses. After 6 weeks of opioid administration, destructive changes in the skin were detected. These, in turn, led to the incomplete regenerate formation in the multiple postinjection wound. The experimental results, hence, show the negative effect of prolonged administration of opioid on the reparative processes in the skin.

7

Differences in Tibiocalcaneal Kinematics Measured with Skin- and Shoe-Mounted Markers

100%

Sinclair J. , Greenhalgh A. , Taylor P. J. , Edmundson C. J. , Brooks D. , Hobbs S. J.

Human Movement

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2013

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tom 14

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nr 1

64-69

EN

Purpose. The aim of the current investigation was to compare the 3-D tibiocalcaneal kinematics between skin- and shoe-mounted markers. Methods. Eleven male participants ran at 4.0m/s ± 5% along a 22 m runway. Tibiocalcaneal kinematics were captured simultaneously using markers placed externally on the shoe and on the skin through windows cut in the shoe. Paired t-tests were used to compare the 3-D kinematic parameters, and intraclass correlations were employed to contrast the kinematic waveforms. Results. Strong correlations were observed between the waveforms at R2 0.85. However, foot movements such as eversion range of motion, peak eversion, peak transverse plane range of motion, velocity of external rotation and peak eversion velocity were all significantly underestimated using shoe-mounted markers. Conclusions. The results indicate that shoe-mounted markers do not fully represent true foot movement.

8

The influence of collagen from various sources on skin parameters

100%

Prus W. , Kozłowska J.

Engineering of Biomaterials

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2018

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tom Vol. 21, no. 148

49

9

Role of skin in compression of berry-like fruits between two plates

100%

Bares J. , Lejckova K. , Patocka K. , Blahovec J.

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nr 3

10

Post-critical deformation states of composite thin-walled aircraft load-bearing structures

88%

Kopecki T. , Bakunowicz J. , Lis T.

Journal of Theoretical and Applied Mechanics

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2016

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tom Vol. 54 nr 1

195--205

EN

The study presents results of experimental examination of a model representing a fragment of an aircraft wing structure with the skin made of a glass fibre/epoxy composite. For such a system, the deformation pattern has been found and the representative equilibrium path determined. The finite element method has been used to develop the corresponding numerical model, the correctness of which has been then verified by comparing the obtained results with the course of the relevant experiment. Conformity of the results allowed one to determine usefulness of the applied methods in the assessment of mechanical properties of modified solutions involving integral skin stiffening elements.

11

Tigecycline - A New Antibiotic in Infections Treatment

88%

Stefaniuk E. , Hryniewicz W.

Polish Journal of Surgery

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2007

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tom 79

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nr 9

587-593

EN

Tigecycline, a member of a new class of antimicrobials (glycylcyclines), was shown to have expanded broad spectrum activity against most commonly encountered species responsible for community and hospital acquired infections, including Gram-positive and Gram-negative multidrug resistant bacterial strains.The aim of the study was to evaluate the activity of tigecycline against resistant bacterial strains commonly associated with nosocomial infections, including skin structure, subcutaneous layer and intra-abdominal infections.Material and methods. Ten general hospitals from different regions of Poland participated in the study. Antimicrobial susceptibility tests were carried for 539 isolates of different genus/species of bacterial strains isolated from patients hospitalized in hospitals throughout Poland. Minimal inhibitory concentrations (MICs) of tigecycline were determined using the broth dilution method.Results. Ten strains of 50 S. aureus isolates, i.e. 20%, were methicillin-resistant (MRSA). The lowest MIC90 values observed for tigecycline were (0.25 μg/ml); they were similar to the MIC50 for MSSA and MRSA.S. pneumoniae varied with respect to their susceptibility to penicillin. Twenty two percent of isolates (n=11) had decreased susceptibility to penicillin. However, all 50 strains of this species were susceptible to levofloxacin, vancomycin and linezolid. Tigecycline exhibited high activity against S. pneumoniae strains. Tigecycline MIC90 values for this group of strains were lower than MIC90 of the remaining antibiotics. One hundred percent of collected S. agalactiae strains were susceptible to all investigated antibiotics.Conclusion. The presented data indicate that tigecycline exhibits excellent inhibitory activity against nosocomial and community pathogens regardless of resistance patterns.

12

Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin

88%

Sarafian V. , Dikov D. , Karaivanov M.

Open Medicine

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2006

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tom 1

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nr 2

119-127

EN

Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of basocellular carcinomas. In spinocellular carcinomas, HBGAs were detected in tumor keratinocytes and in keratin pearls. These results provide new evidence for the differential expression of LAMPs and HBGAs in the normal stratified squamous epithelium, as well as the presence of a modulating reactivity in basocellular and spinocellular carcinomas, suggesting that these glycoproteins are involved in differentiation and tumorigenesis of human skin.

13

Vitamin D in the skin physiology and pathology

88%

Piotrowska A. , Wierzbicka J. , Żmijewski M.

Acta Biochimica Polonica

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2016

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tom 63

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nr 1

17-29

EN

Vitamin D plays important, pleiotropic role in the maintenance of global homeostasis. Its influence goes far beyond the regulation of calcium and phosphorus balance, as diverse activities of vitamin D and its natural metabolites assure proper functioning of major human organs, including skin. Recently, we reviewed the current understanding of vitamin D impact on human health from historical perspective (Wierzbicka et al. (2014) The renaissance of vitamin D. Acta Biochim Pol 61: 679-686). This article focuses on its functions in the skin. The skin and its appendages, creates a platform connecting and protecting internal organs against, usually harmful, external environment. It uppermost layer - epidermis in order to maintain a protective barrier undergoes a constant exchange of cornified keratinocytes layer. Its disturbance leads to development of serious skin disorders including psoriasis, vitiligo, atopic dermatitis and skin cancer. All of those dermatopathologies have a huge impact on modern societies, affecting not only the physical, but also mental state of patients as well as their social status. Furthermore, multiple human systemic diseases (autoimmune, blood and digestive diseases) have skin manifestation, thus "condition of the skin" often reflects the condition and pathological changes within the internal organs. In humans, the skin is the natural source of vitamin D, which is produced locally from 7-dehydrocholesterol in photoreaction induced by ultraviolet B (UVB) radiation from the sun. It is also well established, that the process of proliferation and differentiation of keratinocytes is tightly regulated by calcium and the active form of vitamin D (1,25(OH)2D3). Thus, the skin physiology is inseparably connected with vitamin D production and activity. Unfortunately, UVB, which is required for vitamin D production, is also known as the main cause of a skin cancer, including melanoma. Here, we are going to review benefits of vitamin D and its analogues in the maintenance of epidermal barrier and its potential use in the treatment of common skin diseases.

14

The renaissance of vitamin D

88%

Wierzbicka J. , Piotrowska A. , Żmijewski M.

Acta Biochimica Polonica

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2014

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tom 61

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nr 4

679-686

EN

There is no doubt that vitamin D plays a crucial role in the maintenance of musculoskeletal system. But the function of this ancient molecule presumably ranges far beyond hormone-like regulation, as it could be generated by simple unicellular organisms. First, we are going to discuss the role of vitamin D as a global regulator of homeostasis from a historical perspective, but later we will focus on current views and its relevance to human physiology and pathology. Three milestones are defining the impact of vitamin D on science and humanity. Firstly, discovery that vitamin D is the cure for rickets, brought us supplementation programs and rapid irradiation of this devastating disease. Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Finally, recent large epidemiological studies provided indirect, but strong evidence that optimal level of vitamin D in serum has beneficial effects on our health and protects us from multiple diseases, including cancer. Furthermore, existence of alternative pathways of vitamin D metabolism and multiple intracellular targets broadens our understanding of its physiological activities and offers new and very promising tools for prophylactics and treatment of many diseases of civilization. Although vitamin D (and its derivatives) should not be regarded as a cure-all for every human disease, its beneficial effects on the human health have to be taken under consideration.

15

Histological structure of pig skin in relation to biomechanical properties in prenatal period

88%

Dudek A. , Kuropka P. , Kaleta K. , Pospieszny N. , Szotek S. , Kobielarz M. , Bedzinski R.

Acta Biologica Cracoviensia. Series Botanica. Supplement

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2008

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tom 50

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nr 1

16

A morphological and immunohistochemical investigation of guinea pig skin after the introduction of substance P and VIP

88%

Gendek-Kubiak H. , Danowski J. , Kmiec B. L.

Cellular and Molecular Biology Letters

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2002

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tom 07

|

nr Suppl.

17

The effect of cholinergic receptors on ionic transport in the skin of a frog Rana esculenta L.

88%

Kosik-Bogacka D. , Tyrakowski T.

Zoologica Poloniae

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2001

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tom 46

|

nr 1-4

18

The changes of proteoglycans during the hair cycle in the mink skin

88%

Pak J. , Nakamura F. , Kondo K.

Zeszyty Naukowe. Przegląd Hodowlany

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1996

|

tom 29

19

Magnesium in tumours of the dogs' skin

88%

Brodzki A. , Szponder T. , Pasternak K. , Sztanke M.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 3

20

The number and distribution of blood dendritic cells in the epidermis and dermis of healthy human subjects

88%

Narbutt J. , Lesiak A. , Sysa-Jedrzejowska A. , Smolewski P. , Robak T. , Zalewska A.

Folia Histochemica et Cytobiologica

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2006

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tom 44

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nr 1