Wyniki wyszukiwania - Biblioteka Nauki

1

Modelowanie i symulacja zachowania mięśnia szkieletowego o różnych własnościach dynamicznych

100%

Wojnicz W. , Wittbrodt E.

Zeszyty Naukowe Katedry Mechaniki Stosowanej / Politechnika Śląska

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2004

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tom z. 24

219-224

PL

W artykule został przedstawiony nieliniowy model zachowania mięśnia szkieletowego, który uwzględnia różnorodne własności dynamiczne poszczególnych odcinków mięśnia. Opisane są zasady obliczania współczynników modelu w przypadku mięśnia wypoczętego i zmęczonego. Zaprezentowane zostały zasymulowane ekscentryczne i koncentryczne skurcze oraz bilanse energetyczne dla poszczególnych zachowań mięśnia.

EN

In the paper it has been presented the non-linear model of striated skeletal muscle's behavior which models the heterogeneity of each its part. Its have been described principles of models coefficients computations in case of rested and fatigue muscle, represented simulated eccentric - concentric muscle cramps and its energetic balances.

2

Interleukin-6 As An Adipokine And Myokine: The Regulatory Role Of Cytokine In Adipose Tissue And Skeletal Muscle Metabolism

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Lutosławska G.

Human Movement

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2012

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tom 13

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nr 4

372-379

EN

Purpose. Interleukin-6 (IL-6) belongs to the IL-6-type cytokine family, which, besides IL-6, comprises of IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT) and cardiotrophin-like cytokine (CLC). The metabolic effects of IL-6 differ markedly depending on the nature of the target cell with positive action on nerve cells’ differentiation and hematopoesis, but negative in the etiology of autoimmune disease such as rheumatoid arthritis. In a target cell, IL-6 can simultaneously generate functionally distinct or sometimes contradictory signals depending on the in vivo environment, and the final physiological effect is a consequence of the orchestration of the diverse signals. Thus, its physiological effects are characterized by pleiotropy and redundancy. At present, it has been well documented that in obese individuals, IL-6, as an adipokine secreted into circulation by adipose tissue in proportion to body fat content and an elevated level of the cytokine in the plasma, adversely affects insulin signaling and glucose disposal in skeletal muscles and liver. Moreover, several lines of evidence indicated that IL-6 is a myokine synthesized in skeletal muscle and secreted into the bloodstream in response to exercise. In this way muscular work has a potential to stimulate adipose tissue lipolysis and provides an energy to working muscle. Furthermore, muscle-originated IL-6 acts locally, positively affecting intramuscular fat utilization. It has also been postulated that IL-6 is inevitable for satellite cell stimulation and muscle hypertrophy and repair.

3

Morphology of extensor digitorum longus of Wistar rats after remobilization by vibratory platform

100%

Izabela Rodrigues Camilo I. R. , Maria Luiza Serradourada Wutzke M. L. S. , Rose Meire Costa R. M. , Gladson Ricardo Flor Bertolini G. R. F. , Lucinéia de Fátima Chasko Ribeiro L.

European Journal of Clinical and Experimental Medicine

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2019

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nr 4

295-300

EN

Introduction. In exercise, vibrations are performed in order to produce rapid and short changes in muscle length. These changes are detected by sensory receptors, in response try to dampen the vibratory waves through a modulation of muscle stiffness. However, its effects on the morphology of muscle tissue are still not fully established, especially after long periods of immobilization. Aim. To compare the effects of the vibratory platform on the remobilization of the extensor digitorum longus (EDL) muscle of Wistar rats with free remobilization. Material and methods. 20 rats were divided into: CG (Control), IG (immobilized), IFG (immobilization and free remobilization), IPG (immobilization and remobilization with vibratory platform). The immobilization was performed on the pelvic limb for 15 days. The remobilization with vibratory platform was done for 10 minutes daily, for 2 weeks. The EDL was processed for histological analysis of cross-sections. Results. The area, larger diameter, smaller diameter and fiber density of the EDL muscle of GI presented significant alteration when opposed to CG, IFG and IPG. The density of nuclei of the EDL muscle of IG presented a significant increase when opposed to the others, and IPG also presented a significant increase when compared to CG. Conclusion. The morphology and morphometry of the EDL muscle tissue were affected, and both free and vibration platform remobilization re-established the morphological aspects of the muscle fiber, without significant differences between the methods.

4

Low-level laser therapy on the rat’s gastrocnemius morphometry submitted to a rheumatoid arthritis model

100%

Marin E. , Fuse J. L. , Lopes L. P. , Neves M. , da Silva Leal T. S. , de Fátima Chasko Ribeiro L. , Bertolini G. R. F.

European Journal of Clinical and Experimental Medicine

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2021

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nr 2

111-115

EN

Introduction. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disease of unknown origin, mainly affecting synovial joints and related structures, including the adjacent musculature, generating great disability and reduction in quality of life. Aim. This study was designed to investigate the effect of low-level laser therapy (LLLT) on gastrocnemius of Wistar rats subjected to an experimental model of RA. Material and methods. Forty male Wistar rats were used, separated into: acute and chronic, being subdivided into Control Group (CG): without intervention, Lesion Group (LG): submitted to lesion, Laser Control Group (LCG): without lesion and with treatment, and Laser Lesion Group (LLG): submitted to lesion and LLLT. The treatment with LLLT occurred in four points of the right knee, wavelength of 660 nm, energy density of 5 J/cm², energy per point of 0.003 J. Morphometric analysis was performed using a 40x magnification photomicrograph and analyzed using the Image-Pro-Plus 6.0 program. Results. As result of the acute group there was a difference only for muscle mass, being higher in CG. For the chronic group there was significant difference for cross-sectional area, larger and smaller diameter, again with the control group obtaining higher values than the others, for the number of nuclei LG was lower than CG and LCG, but LLG was not different from any of them. Conclusion. It is concluded that treatment with LLLT was not very effective in reversing the harmful effects of RA on the gastrocnemius muscle.

5

Neural impacts on the regeneration of skeletal muscles.

100%

Pintér S. , Mendler L. , Dux L.

Acta Biochimica Polonica

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2003

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tom 50

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nr 4

1229-1237

EN

The regeneration of skeletal muscles is a suitable model to study the development and differentiation of contractile tissues. Neural effects are one of the key factors in the regulation of this process. In the present work, effects of different reinnervation protocols (suture or grafting) were studied upon the regenerative capacity of rat soleus muscles treated with the venom of the Australian tiger snake, notexin, which is known to induce complete necrosis and subsequent regeneration of muscles. Morphological and motor endplate analysis indicated that the regenerative capacity of denervated, and thereafter surgically reinnervated muscles remains impaired compared to that of normally innervated muscles, showing differences in the muscle size, fiber type pattern and motor endplate structure, even 35 days after the notexin injection. A lack or deficiency of secreted neural factors, deterioration of satellite cells and/or incomplete recovery of the sutured or grafted nerves may be the cause of these discrepancies in the regeneration process.

6

The significance of myosin light chains in mechanochemical coupling in skeletal muscle

100%

Stepkowski D. , Kakol I.

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nr 3

7

Tissue variation of mitochondrial oxidative phosphorylation efficiency in cold-acclimated ducklings

88%

Salin K. , Teulier L. , Rey B. , Rouanet J.-L. , Voituron Y. , Duchamp C. , Roussel D.

Acta Biochimica Polonica

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2010

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tom 57

|

nr 4

409-412

EN

We investigated the oxidative phosphorylation efficiency of liver and gastrocnemius muscle mitochondria in thermoneutral and cold-acclimated ducklings. The yield of oxidative phosphorylation was lower in muscle than in liver mitochondria, a difference that was associated with a higher proton conductance in muscle mitochondria. Cold exposure did not affect oxidative phosphorylation efficiency or basal proton leak in mitochondria. We conclude that the basal proton conductance of mitochondria may regulate mitochondrial oxidative phosphorylation efficiency, but is not an important contributor to thermogenic processes in cold-acclimated ducklings.

8

An inverse procedure for characterization of material parameters of passive skeletal muscle using FEM and experimental data

88%

Liu S. , Sang J. , Zhang Y. , Zhao L. , Liu G.

Journal of Theoretical and Applied Mechanics

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2020

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tom Vol. 58 nr 1

247--259

EN

This work develops an inverse procedure which combines an improved niche genetic algorithm, finite element models and experimental data to identify material parameters of biological tissues behaving like hyperelastic materials. A novel objective function is proposed with two coefficients, which controls the contributions in a well-balanced fashion, respectively, for the small deformation stage and the large deformation stage. This allows us to obtain a global minimizer (of material constants) for the error between FEM solutions and experimental data. Moreover, simple uniaxial compression tests at two different angles (0◦ and 90◦) with respect to the muscle fiber orientation are performed on fresh muscle tissues. This enables us to obtain anisotropic properties of the muscle tissue from the present inverse procedure. The result shows that the proposed inverse procedure is stable and reliable to determine material constants in hyperelastic models for soft biological tissues like skeletal muscles considering anisotropy.

9

The effect of cadmium on the utilization of free fatty acids in the skeletal muscles in rats

88%

Falkus B. , Kielan Z. , Ziolkowska B. , Jethon Z.

Acta Biologica Silesiana

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1990

|

tom 15

10

Galectin-1 expression in innervated and denervated skeletal muscle

88%

Svensson A. , Tagerud S.

Cellular and Molecular Biology Letters

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2009

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tom 14

|

nr 1

128-138

EN

Galectin-1 is a soluble carbohydrate-binding protein with a particularly high expression in skeletal muscle. Galectin-1 has been implicated in skeletal muscle development and in adult muscle regeneration, but also in the degeneration of neuronal processes and/or in peripheral nerve regeneration. Exogenously supplied oxidized galectin-1, which lacks carbohydrate-binding properties, has been shown to promote neurite outgrowth after sciatic nerve sectioning. In this study, we compared the expression of galectin-1 mRNA and immunoreactivity in innervated and denervated mouse and rat hind-limb and hemidiaphragm muscles. The results show that galectin-1 mRNA expression and immunoreactivity are up-regulated following denervation. The galectin-1 mRNA is expressed in the extrasynaptic and perisynaptic regions of the muscle, and its immunoreactivity can be detected in both regions by Western blot analysis. The results are compatible with a role for galectin-1 in facilitating reinnervation of denervated skeletal muscle.

11

Isolation and characterization of pigeon breast muscle cytosolic 5´-nucleotidase-I (cN-I)

88%

Tkacz-Stachowska K. , Lechward K. , Skladanowski A. C.

Acta Biochimica Polonica

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2005

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tom 52

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nr 4

789-796

EN

5´-Nucleotidase specific towards dCMP and AMP was isolated from avian breast muscle and characterized. It was found to be similar to a type-I form (cN-I) identified earlier as the AMP-selective 5´-nucleotidase responsible for adenosine formation during ATP breakdown in transfected COS-7 cells. Expression pattern of the cN-I gene in pigeon tissues indicated breast muscle as a rich source of the transcript. We purified the enzyme from this source using two-step chromatography and obtained an active homogenous preparation, free of ecto-5´-nucleotidase activity. The tissue content of the activity was calculated at 0.09 U/g wet weight. The specific activity of the enzyme preparation was 4.33 U/mg protein and it preferred dCMP and AMP to dAMP and IMP as a substrate. Its kinetic properties were very similar to those of the enzyme purified earlier from heart tissue. It was strongly activated by ADP. Inhibition by inorganic phosphate was more pronounced than in heart-isolated cN-I. Despite this difference, a similar physiological function is suggested for cN-I in both types of muscle.

12

Ganoderma lucidum extract stimulates glucose uptake in L6 rat skeletal muscle cells

88%

Jung K. H. , Ha E. , Kim M.-J. , Uhm Y. K. , Kim H. K. , Hong S.-J. , Chung J.-H. , Yim S.-V.

Acta Biochimica Polonica

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2006

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tom 53

|

nr 3

597-601

EN

The effect of Ganoderma lucidum extract on glucose uptake was studied in L6 rat skeletal muscle cells. G. lucidum extract increased glucose uptake about 2-fold compared to control. The extract stimulated the activity of phosphatidylinositol (PI) 3-kinase which is a major regulatory molecule in the glucose uptake pathway. About 7-fold increased activity of a PI 3-kinase was observed after treatment with G. lucidum extract, whereas PI 3-kinase inhibitor, LY294002, blocked the G. lucidum extract-stimulated PI 3-kinase activity in L6 skeletal muscle cells. Protein kinase B, a downstream mediator of PI 3-kinase, was also activated by G. lucidum extract. We then assessed the activity of AMP-activated protein kinase (AMPK), another regulatory molecule in the glucose uptake pathway. G. lucidum extract increased the phosphorylation level of both AMPK α1 and α2. Activity of p38 MAPK, a downstream mediator of AMPK, was also increased by G. lucidum extract. Taken together, these results suggest that G. lucidum extract may stimulate glucose uptake, through both PI 3-kinase and AMPK in L6 skeletal muscle cells thereby contributing to glucose homeostasis.

13

A possible origin of the torocyte-like shape of vesicles derived from the transverse tubule in the triad junction of skeletal muscle

88%

Iglic A. , Fosnaric M. , Kralj-Iglic V.

Cellular and Molecular Biology Letters

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2003

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tom 08

|

nr 3

EN

The origin of characteristic torocyte-like shape of vesicles derived from transverse tubule in triad junction of skeletal muscles is studied theoretically. Two possible mechanisms are suggested. The first is the minimization of membrane bending energy where the special intermediate molecular structures in the central region of the vesicle is assumed to protect the opposing bilayers to come in the direct contact. The second mechanism is based on the assumption that the characteristic shape of the vesicles may be explained by non-homogenous lateral distribution of anisotropic membrane components.

14

Neural impacts on the regeneration of skeletal muscles

88%

Pinter S. , Mendler L. , Dux L.

Acta Biochimica Polonica

|

2003

|

tom 50

|

nr 4

EN

The regeneration of skeletal muscles is a suitable model to study the development and differentiation of contractile tissues. Neural effects are one of the key factors in the regulation of this process. In the present work, effects of different reinnervation protocols (suture or grafting) were studied upon the regenerative capacity of rat soleus muscles treated with the venom of the Australian tiger snake, notexin, which is known to induce complete necrosis and subsequent regeneration of muscles. Morphological and motor endplate analysis indicated that the regenerative capacity of denervated, and thereafter surgically reinnervated muscles remains impaired compared to that of normally innervated muscles, showing differences in the muscle size, fiber type pattern and motor endplate structure, even 35 days after the notexin injection. A lack or deficiency of secreted neural factors, deterioration of satellite cells and/or incomplete recovery of the sutured or grafted nerves may be the cause of these discrepancies in the regeneration process.

15

The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs

88%

Otrocka-Domagala I. , Rotkiewicz T. , Karpinska J. , Purzynska-Pugacewicz A. , Kasperowicz B. , Mikolajczyk A. , Babinska I.

Polish Journal of Veterinary Sciences

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2004

|

tom 07

|

nr 4

EN

The aim of the study was to observe the effect of coenzyme Q10 and vitamin E supplementation on the course of the regeneration process of the longissimus lumborum muscle after bupivacaine-induced myonecrosis as well as to determine the correlation between the level of those substances in plasma and their levels in damaged and non-damaged muscular tissue in pigs. The obtained results indicate that the course of regeneration of a damaged muscle is affected to a higher extent by coenzyme Q10 than by vitamin E. The administration of coenzyme Q10 and vitamin E has a significant impact on the increase in the level of those substances in damaged muscles and plasma of animals.

16

Effect of denervation and tenotomy on nucleotidase activity in rat skeletal muscles

88%

Rutkiewicz J. , Czarnowski D. , Gorski J.

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nr 4

17

Effect of exercise on adenosine deaminase activity in rat skeletal muscles

88%

Rutkiewicz J. , Gorski J.

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nr 3

EN

Adenosine deaminase activity was shown to decrease in each skeletal muscle type (the slow-twitch oxydative, fast-twitch oxydative - glycolytic and fast-twitch glycolytic) at the beginning of exercise of moderate intensity and to return to the control when exercise was continued till exhaustion. 5 min occlusion of the femoral artery had no effect on the enzyme activity in either muscle. The reduction of the enzyme activity at the onset of exercise could result in reduction of adenosine breakdown and thus contribute to vasodilation at this stage of increased contractile activity of the muscles.

18

Effects of forskolin on the acetylcholine receptors of rat skeletal muscle fibres in culture

88%

Mozrzymas J. W. , Lorenzon P. , Grassi F. , Eusebi F. , Ruzzier F.

Biophysics of Membrane Transport

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1994

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tom 12

|

nr 2

19

Muscular dystrophy in mice caused by two different alterations of dystrophin gene

88%

Rowinski J. , Kozlowska H. , Sulikowska-Rowinska A. , Rejment E.

Folia Histochemica et Cytobiologica

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2001

|

tom 39

|

nr 2

20

Activity of mi and m-calpain in regenerating fast and slow twitch skeletal muscle

88%

Moraczewski J. , Piekarska E. , Zimowska M. , Sobolewska M.

Acta Biochimica Polonica

|

1996

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tom 43

|

nr 4

EN

Calpains — non-lysosomal intracellular calcium-activated neutral proteinases, form a family consisting of several distinct members. Two of the isoenzymes: ji (calpain I) and m (calpain II) responded differently to the injury during complete regeneration of Extensor digitorum longus (EDL) muscle and partial regeneration of Soleus muscle. In the crushed EDL the level of m-calpain on the 3rd and 7th day of regeneration was higher than in non-operated muscles, whereas the activity of this calpain in injured Soleus decreased. The level of n-calpain in EDL oscillated irregularly during regeneration whereas in Soleus of both injured and contralateral muscles its level rapidly rose. Our results support the hypothesis that m-calpain is involved in the process of fusion of myogenic cells whereas u-calpain plays a significant but indirect role in muscle regeneration.