Wyniki wyszukiwania - Biblioteka Nauki

1

Technical solutions for bio-measurements

100%

Konieczny L. , Markiewicz M. , Piwowar P. , Roterman I.

|

2012

|

tom Vol. 8, no. 4

339--349

EN

Biological processes are controlled automatically. Registration of signals and measuring their relative strength is hence a key problem. Receptors may be relatively simple or complex. The complexity is the direct response to ambiguity of signals. If there is however a common feature of diverse signals a construction of generic receptor mechanism is usually observed. Combinatorial technique is commonly used in biological systems to decrease the complexity in reception of highly ambiguous signals.

2

The role of the NUR77 family of nuclear receptors in the signalling pathways of thymocytes and neurons

100%

Matuszyk J.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

3

Signalling protein inhibitors via the combinatorial modification of peptide scaffolds

88%

Lawrence D. S.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

4

Signalling pathways regulating transcription, mRNA stabilisation and intracellular transport of cytokines in activated mast cells

88%

Dastych J. , Walczak-Drzewiecka A. , Adamczewska V. , Trzaska D. , Olszewski M. , Wyczolkowska J.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

5

Regulator of G-protein signalling expression and function in ovarian cancer cell lines

75%

Hurst J. H. , Mendpara N. , Hooks S. B.

|

2009

|

tom 14

|

nr 1

153-174

EN

Regulator of G-protein signalling (RGS)2 proteins critically regulate signalling cascades initiated by G-protein coupled receptors (GPCRs) by accelerating the deactivation of heterotrimeric G-proteins. Lysophosphatidic acid (LPA) is the predominant growth factor that drives the progression of ovarian cancer by activating specific GPCRs and G-proteins expressed in ovarian cancer cells. We have recently reported that RGS proteins endogenously expressed in SKOV-3 ovarian cancer cells dramatically attenuate LPA stimulated cell signalling. The goal of this study was twofold: first, to identify candidate RGS proteins expressed in SKOV-3 cells that may account for the reported negative regulation of G-protein signalling, and second, to determine if these RGS protein transcripts are differentially expressed among commonly utilized ovarian cancer cell lines and non-cancerous ovarian cell lines. Reverse transcriptase-PCR was performed to determine transcript expression of 22 major RGS subtypes in RNA isolated from SKOV-3, OVCAR-3 and Caov-3 ovarian cancer cell lines and non-cancerous immortalized ovarian surface epithelial (IOSE) cells. Fifteen RGS transcripts were detected in SKOV-3 cell lines. To compare the relative expression levels in these cell lines, quantitative real time RT-PCR was performed on select transcripts. RGS19/GAIP was expressed at similar levels in all four cell lines, while RGS2 transcript was detected at levels slightly lower in ovarian cancer cells as compared to IOSE cells. RGS4 and RGS6 transcripts were expressed at dramatically different levels in ovarian cancer cell lines as compared to IOSE cells. RGS4 transcript was detected in IOSE at levels several thousand fold higher than its expression level in ovarian cancer cells lines, while RGS6 transcript was expressed fivefold higher in SKOV-3 cells as compared to IOSE cells, and over a thousand fold higher in OVCAR-3 and Caov-3 cells as compared to IOSE cells. Functional studies of RGS 2, 6, and 19/GAIP were performed by measuring their effects on LPA stimulated production of inositol phosphates. In COS-7 cells expressing individual exogenous LPA receptors, RGS2 and RSG19/GAIP attenuated signalling initiated by LPA1, LPA2, or LPA3, while RGS6 only inhibited signalling initiated by LPA2 receptors. In SKOV-3 ovarian cancer cells, RGS2 but not RGS6 or RGS19/GAIP, inhibited LPA stimulated inositol phosphate production. In contrast, in CAOV-3 cells RGS19/GAIP strongly attenuated LPA signalling. Thus, multiple RGS proteins are expressed at significantly different levels in cells derived from cancerous and normal ovarian cells and at least two candidate RGS transcripts have been identified to account for the reported regulation of LPA signalling pathways in ovarian cancer cells.

6

Endocannabinoid signalling: a common target for high fat diets and substances of abuse?

75%

Di Marzo V.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 5

7

Deep data analysis in gigabit passive optical networks

75%

Horvath T. , Krkos R. , Dubravec L.

Optica Applicata

|

2017

|

tom Vol. 47, nr 1

157--170

EN

This paper focuses on practical aspects of gigabit passive optical networks (GPON) diagnostics during deployment, for root-cause analysis and for research purposes. While GPON signalling analysis is already quite commonly used for diagnostics, the aim of this work is a holistic approach, including both signalling and user plane (payload) analysis. User plane analysis, especially if targeted at payload Ethernet, IP and transport layers, enables detection of additional group of problems that could limit or even prevent GPON internetworking and thus degrade the user perceived service quality. Integrated signalling and payload analysis is also interesting from the research point of view, leading to the ability to study equipment idiosyncrasies that would be hard to detect otherwise and it is also one of the enablers of equipment security verification. The mentioned theories were tested during a practical diagnostic session on a real GPON network deployment and this paper presents the findings.

8

Method for Reduction Indefinite Routing Loops Probability in the Mixed Telephone Network of Electric Power Utility

75%

Mileusnić M. , Lebl A. , Mitić D. , Markov Ž.

Przegląd Elektrotechniczny

|

2013

|

tom R. 89, nr 3a

136--140

EN

In this paper, we present the method for reducing the probability of indefinite looping in single-layer (non-hierarchical) telephone network of Electric Power Utility. The method is based on the detection of the first loop after the reception of two initial signalling messages, which contain the same source and destination addresses. In this case the network node, where the first loop is detected, changes its routing plan. The method can’t eliminate loop appearance completely, and it is not applicable when overlap signalling is used.

PL

W artykule opisano metodą redukcji prawdopodobieństwa wystąpienia pętli warunkowych w jednowarstwowej sieci telefonicznej operatora energetycznego. W metodzie dokonywana jest detekcja pierwsze pętli, o takim samym adresie źródłowym i docelowym, która wystąpi po wykryciu wiadomości inicjalizacyjnych. Następnie następuje zmiana routowania. Metoda nie eliminuje pętli w zupełności.

9

Signalling: basics and evolution.

75%

Robert J.P Williams

Acta Biochimica Polonica

|

2004

|

tom 51

|

nr 2

281-298

EN

Signalling concerns the transfer of information from one body, a source, to another, a receiver in order to stimulate activity. The problem arises with the word information. It is defined as what is transferred in a sequence of things, say between people, e.g. words or signs. The idea of signalling between people is then obvious but it is not clear in cell biology. Information transfer, signalling, is required for the organisation of all cellular activity but we must ask what is transferred and how is it transmitted and received? Sometimes it is assumed that all information, i.e. organisation in a cell, is represented in the DNA sequence. This is incorrect. We shall show that the environment is a second source of information concerning material and energy. The receiving party from both DNA and the environment is general metabolism. The metabolism then signals back and sends information to both DNA and uptake from the environment. Even then energy is needed with machinery to send out all signals. This paper examines the way signalling evolved from prokaryotes through to man. In this process the environmental information received increased to the extent that finally the brain is a phenotypic as much as a genotypic organ within a whole organism. By phenotypic we mean it is organised by and interactive with information from the environment.

10

Execution of contradictory commands in automatic line block system

75%

Olpiński W.

Archives of Transport System Telematics

|

2009

|

tom Vol. 2, iss. 1

17-22

EN

Th e automatic line block system may be constructed as a chain of autonomous distributed set of functional blocks located along a railway line section, interlocked by the data transmission subsystem and controlled from two ends of the section. Thus, a certain possibility of simultaneously issued contradictory commands creating conflicts during their execution to be settled by a functional block controlled by them particularly while the data transmission subsystem failure occurs have to be considered. Testing of automatic line block system proper functioning in a range of reaction to contradictory commands and examples of typical conflicts and general rules of solving them are discussed in the paper.

11

Jednolita metoda badania kompatybilności elektromagnetycznej taboru i urządzeń stwierdzania niezajętości toru

75%

Adamski D. , Olpiński W.

Zeszyty Naukowo-Techniczne Stowarzyszenia Inżynierów i Techników Komunikacji w Krakowie. Seria: Materiały Konferencyjne

|

2014

|

tom Nr 2(104)

7--22

PL

Coraz częściej do stwierdzania niezajętości toru stosowane są urządzenia licznikowe, których zasadniczymi elementami są czujniki koła. Równocześnie coraz bardziej złożony tabor kolejowy, szczególnie pojazdy trakcyjne, stanowią źródło potencjalnych zakłóceń mogących oddziaływać na pracę takich urządzeń detekcji taboru. W procesie dopuszczania nowych pojazdów szynowych do eksploatacji prowadzona jest więc weryfikacja ich kompatybilności elektromagnetycznej (EMC) ze stosowanymi urządzeniami sterowania ruchem kolejowym, zwłaszcza z systemami stwierdzania niezajętości toru. Jednym z elementów prowadzonych badań jest ocena zakłócających pól magnetycznych wytwarzanych przez tabor. Dla ujednolicenia i uproszczenia metod pomiaru takich zakłóceń prowadzono prace nad normą EN 50238 i opracowano specyfikację techniczną TS 50238-3. Specyfikacja ta określa jednolitą metodę pomiarową. Stosowanie jej wymaga sprawdzenia, czy może ona zastąpić różne sposoby pomiaru stosowane w poszczególnych krajach europejskich. W tym celu realizowany jest europejski projekt badawczy, finansowany ze środków europejskiej sieci transportowej TEN-T w ramach projektu mającego ułatwić i przyspieszyć wprowadzanie europejskiego systemu zarządzania ruchem kolejowym – ERTMS. Jedna z dziewięciu kampanii pomiarowych zaplanowanych w ramach projektu przeprowadzona została w Polsce. Po rozwinięciu opisanego powyżej wprowadzenia, w artykule omówiono cechy wykorzystywanej, specjalistycznej aparatury pomiarowej, zgodnej ze specyfikacją TS 50238-3. Przedstawiono także przebieg i wyniki polskiej kampanii pomiarowej oraz docelowe przeznaczenie rezultatów całego projektu.

EN

Axle counters are more and more often applied in train detection systems. The wheel sensor is a main part of each axle counter system. In parallel, more and more complex railway vehicles, especially traction ones, are a potential source of interferences influencing the operation of these train detection systems. It is the reason to verify the electromagnetic compatibility (EMC) between the signalling equipment, particularly train detection systems, and new vehicles in the process of obtaining the permission for their exploitation. The measurement of interfering magnetic fields generated by vehicles is one of tests to be carried out. For the simplification and unification purpose of the applied interference test methods the EN 50236 standard and TS 60238-3 technical specification have been developed. The specification defines unified testing procedures. However, it is necessary to verify if it may replace different testing methods used in particular European states. It is the goal of the European research project financed from the TEN-T network resources. This project is part of the larger project aiming to facilitate and speed up the ERTMS system deployment. One of nine measurement campaigns planned in the frame of this project was conducted in Poland. After a detailed description of the introduction shortly presented above, the specialized measurement equipment applied in accordance with the TS 50238-3 is presented in the paper. The Polish measurement campaign course and results as well as the final purpose of the whole project achievements are also included in the paper.

12

Pryncypia sygnalizacji w miejskim transporcie zbiorowym

75%

Molecki B.

TTS Technika Transportu Szynowego

|

2012

|

tom R. 19, nr 7-8

41-46

PL

Systemy sterowania ruchem między poszczególnymi gałęziami transportu różnią się bardzo znacząco. W transporcie drogowym sterowanie opiera się na przekazywaniu kierowcom sugestii właściwego zachowania, w zasadzie bez kontroli ich bieżącego postępowania (przykładem może być wyświetlanie sygnału zezwalającego na wjazd na skrzyżowanie nawet, gdy jest ono całkowicie zastawione pojazdami). W transporcie szynowym osoba prowadząca pojazd ma z kolei dużo mniejszy wpływ na ruch pojazdu - najczęściej tor jazdy jest narzucony, regulacji podlega jedynie prędkość przemieszczania. Na pograniczu tych systemów znajduje się miejski transport zbiorowy - do którego należą zarówno pojazdy drogowe, jak i szynowe.

13

Priming through H2O2-mediated signalling in Arabidopsis thaliana

75%

Balazadeh S. , Shahnejat-Bushehri S. , Muller-Rober B.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

|

2013

|

tom 94

|

nr 2

14

Hybrid Petri nets traffic signal control

75%

Tolba C. , Lefebvre D. , Thomas P. , El Moudni A.

Zeszyty Naukowe. Transport / Politechnika Śląska

|

2003

|

tom z. 51

521-529

EN

This paper begins an introduction. In section 2, the studied system (isolated crossroad) is described. A proposed hybrid Petri nets of traffic at crossroad and a multi-model approach are presented in section 3. The traffic signal control and the simulations results are reported in section 4. Finally, a conclusions and future works are given in section 5.

PL

Artykuł koncentruje się na badaniu sygnalizacji ruchu opartej na modelach sieci Petriego. Ruch pojazdów jest zjawiskiem o charakterze hybrydowym, który przyjmuje formę ciągłą w odcinkach drogi oraz dyskretną na skrzyżowaniach. Stąd rozważono stałe sieci Petri ze zmienną prędkością (VCPN) oraz uzależnione czasowo sieci Petri (TPN) jako odpowiednie narzędzie do modelowania, analizy, oceny parametrów i projektu sterowania miejskimi i międzymiejskimi sieciami drogowymi.

15

Signalling and multiple regulatory mechanisms for NADPH oxidase-mediated deliberate ROS production in plant cells

75%

Kuchitsu K. , Kitahata N. , Kimura S. , Kawarazaki T. , Kaya H. , Kurusu T.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

|

2013

|

tom 94

|

nr 2

16

Qa-SNARE protein SYP22 negatively regulates brassinosteroid signaling in the dark

75%

Yao T. S. , Zhu X. F. , Jung J. H. , Xuan Y. H.

Acta Biologica Cracoviensia. Series Botanica

|

2015

|

tom 57

|

nr 2

17

The involvement of PPAR-alpha and PPAR-gamma signalling in long-term changes in lipogenic enzyme gene expression, as observed in rat adipose tissue after food restriction

75%

Kochan Z. , Karbowska J.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

18

Molecule dependent chemotactic responses of Tetrahymena pyriformis elicited by volatile oils

75%

Kohidai L. , Lemberkovics E. , Csaba G.

Acta Protozoologica

|

1995

|

tom 34

|

nr 3

19

The immunological synapse

75%

Klemmensen T. , Pedersen L. O. , Geisler C.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 6

20

The decrease in PPAR-alpha signalling in the failing human heart - a possible explanation for energy substrate preference switch

75%

Karbowska J. , Kochan Z. , Smolenski R. T.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.