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Trafficking of FoxP3plus regulatory T cells: myths and facts

100%

Kim C. H.

Archivum Immunologiae et Therapiae Experimentalis

2007

tom 55

nr 3

P-selectin mediates adhesion of leucocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

84%

Chen M. , Geng J. G.

Archivum Immunologiae et Therapiae Experimentalis

2006

tom 54

nr 2

Tumor cell N-glycans in metastasis

84%

Laidler P. , Litynska A.

Acta Biochimica Polonica

1997

tom 44

nr 2

Metastasis accounts for most of deaths caused by cancer. The increasing body of evidence suggests that changes in N-glycosylation of tumor cell proteins such as increased branching, increased sialylation, polysialylation, decreased fucosylation, enhanced formation of Lewis X and sialyl Lewis X antigens are among important factors determining metastatic potential of tumor cell. Most of the adhesion proteins, e.g., integrins, members of immunoglobulin superfamily, and cadherins are heavily N-glycosylated. The other proteins involved in adhesion, like galectins and type-C selectins, recognize N-glycans as a part of their specific ligands. In this review we focus on recent reports concerning the contribution of N-glycosylation of tumor cell adhesion molecules and some selected membrane proteins in the tumor invasion and metastasis.