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Journey so far with COVID 19 – a comprehensive review

100%

Sayak Roy S.

nr 4

303-317

Introduction. The occurrence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as a global pandemic with huge death tolls. Coronavirus disease 2019 (COVID-19) may progress from minimal infection to serious respiratory failure mandating treatment for a continuum of developed disease condition. Aim. The purpose of this review is to summarize the findings related to epidemiology, clinical manifestations, modes of transmission, diagnosis and the treatment modalities (both experimental and repurposed) for COVID-19. Material and methods. Literature were searched using various search engines like PubMed, SCOPUS, EMBASE, J-Gate, Google Scholar to look for review articles, randomized controlled trial results, prospective studies and, retrospective studies done on COVID-19 for the purpose of this comprehensive review. Analysis of the literature. The transmission seems to be occurring through droplet, fomite and aerosols (rarely). Currently there is no specific/targeted vaccine available. Priority is highly placed to identify possible treatment approaches to circumvention this disease. Conclusion. Till we find a vaccine, we have to strategize to optimally use the existing evidence of the indirect effects of these various available drugs for therapy and maintain a strict protocol for prevention and we must use triage system to admit only those critically ill or having severe disease.

In vitro immune evaluation of adenoviral vector-based platform for infectious diseases

75%

Baran J. , Kuryk L. , Szczepinska T. , Lazniewski M. , Garofalo M. , Mazurkiewicz-Pisarek A. , Mikiewicz D. , Mazurkiewicz A. , Trzaskowski M. , Wieczorek M. , Pancer K. , Hallmann E. , Brydak L. , Plewczynski D. , Ciach T. , Mierzejewska J. , Staniszewska M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2023

tom 104

nr 4

Occurrence of the nan1 gene and adhesion of Pseudomonas aeruginosa isolates to human buccal epithelial cells

63%

Wolska K. , Kot B. , Mioduszewska H. , Sempruch C. , Borkowska L. , Rymuza K.

nr 1

Prescriptions of broad-spectrum antibiotics to outpatients do not match increased prevalence and antibiotic resistance of respiratory pathogens in Bavaria

63%

Borgmann S. , Jakobiak T. , Gruber H. , Schroder H. , Sagel U.

nr 2

105-110

In this study we present an analysis of prescription numbers of various antibiotic classes to Bavarian (Southern Gennany) outpatients between 2000 and 2006 compared to fluctuating resistance patterns in representative respiratory pathogens. Prescriptions of "narrow-spectrum" antibiotics (e.g. penicillins, macrolides) decreased by 39% while prescriptions of "broad-spectrum" antibiotics increased by 38%. The most prominent increase was for quinolones and cephalosporines class II. Prescriptions of these antibiotics exhibited prominent seasonal alterations suggesting that these drugs had been used for treatment of respiratory infections. In contrast, the numbers of S. pneumoniae and H. influenzae detected in respiratory specimen decreased. Almost constant resistance rates of S. pneumoniae for first line antibiotics do not justify an increased use of cephalosporins class II and quinolones. Compared to Europe and Gennany in general, consumption of antibiotics is low in Bavaria. Even at this low level we propose an education of physicians treating outpatients in a way to avoid an excessive use of antimicrobials.