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Rational design of herbicides

100%

Kafarski P. , Berlicki L.

Pestycydy

2004

nr 3-4

Snizenie materialoemkosti kombinirovannych metalliceskich konstrukcij

75%

Gogol M. , Ordon-Beska B.

Budownictwo o Zoptymalizowanym Potencjale Energetycznym

2015

tom nr 1(15)

61--69

V stat’e rassmotreny voprosy rascetnogo obosnovania racional’nych geometriceskich parametrov kombinirovannych metalliceskich konstrukcij s ponizennoj energoemkost’u za scet minimizacii raschoda metalla.

The paper deals with the design of rational justification of the geometric parameters of combined metal structures with lower energy capaсity due to minimization of material consumption.

Molecular modelling in the rational design of some anti-tumor and antifungal agents

75%

Mazerski J. , Borowski E.

TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk

1998

tom Vol. 2, No 4

511-550

In this paper we present our approaches and results concerning application of molecular modelling techniques in the design of new chemotherapeutic agents for the control of eukariotic systems, comprising compounds for the treatment of systemic fungal infections and tumor deseases. In the case of anti-tumor agents we focused our attention on molecular properties of natural and synthetic anthraquinones. In the area of antifungal compounds we adopted two approaches. In one of them we examine molecular nature of undesirable properties of polyene macrolide antifungal antibiotic - amphotericin B using molecular modelling techniques. Another approach was aimed at the development of selective inactivator of glucosamine synthase, a novel target for antifungal compounds. In this problem we have used computational chemistry methods to identify structural features responsible for the selective inactivation of the target enzyme.

The stand for resource tests of drive lines the close circuit

63%

Pastukhov A.

Motrol. Motoryzacja i Energetyka Rolnictwa

2013

tom 15

nr 7

Rational design of rotor of the asynchronous motor fan for cooling units of diesel locomotives

63%

Zakharchuk I. , Zakharchuk O. , Bukhtiyarov I.

Teka Komisji Motoryzacji i Energetyki Rolnictwa

2014

tom 14

nr 1

Short Peptides in Minimalistic Biocatalyst Design

63%

Duncan K. L. , Ulijn R. V.

Biocatalysis

2014

tom 1

nr 1

We review recent developments in the use of short peptides in the design of minimalistic biocatalysts focusing on ester hydrolysis. A number of designed peptide nanostructures are shown to have (modest) catalytic activity. Five features are discussed and illustrated by literature examples, including primary peptide sequence, nanosurfaces/scaffolds, binding pockets, multivalency and the presence of metal ions. Some of these are derived from natural enzymes, but others, such as multivalency of active sites on designed nanofibers, may give rise to new features not found in natural enzymes. Remarkably, it is shown that each of these design features give rise to similar rate enhancements in ester hydrolysis. Overall, there has been significant progress in the development of fundamental understanding of the factors that influence binding and activity in recent years, holding promise for increasingly rational design of peptide based biocatalysts.

Speeds of movement of the point of gearing along contact lines in screw gear globoid cylindrical tooth gearing

63%

Ututov N. , Plyasulya N.

Teka Komisji Motoryzacji i Energetyki Rolnictwa

2014

tom 14

nr 1

Glutathione transferases and serine proteases: from probing mechanism of enzyme catalysis by rational protein engineering to evolutionary design of enzyme function

63%

Sroga G. E.

nr 3