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1 Polish Journal of Environmental Studies

1 1997

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Effect of combined prenatal exposure to aluminium and ethanol on central dopamine, serotonin and muscarine receptor reactivity in rats

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Brus R. , Szkilnik R. , Nowak P. , Mikolajun U. , Tramer W. , Mengel K.

nr 2

Ethanol (EtOH) abuse in pregnancy is know to seriously damage the internal organs of the fetus, a condition in humans that is classified as "fetal alcohol syndrome". Aluminium (Al) can develop neurotoxic effects and contribute to some neurological disorders. To test whether the reactivity of some central receptors (dopamine - DA, serotonin-5-HT and muscanne - M) may be altered by prenatal EtOH and Al, administered separately or jointly, female rats were given 10% (v/v) EtOH and/or Al(600 or 3000 ppm) throughout pregnancy in their drinking water. Male adult offspring were tested at 3 months for behavioural effects know to be induced by agonists acting at different subtypes of DA (D1 D2, D3,), 5-HT2t and M receptors. Addition antagonist of D, receptor have been examined. The substances SKF 38393, quinpirole, mCPP, pilocarpine, haloperidol, and the behavioral procedures of yawning, oral activity and catalepsy have been used for assessment. The results of the experiment indicate that EtOH does not modify the effect of the central DA and M receptor agonist and DA antagonist in Al prenataly exposed rats. On the other hand, EtOH modified the reactivity of the central 5-HT2c receptor to agonist (mCPP) in Al pretreated rats.