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8
Content available Toxoplasma gondii and mast cells
86%
EN
Mast cells, discovered by Paul Burnet over one century ago, have been long recognized only as inductors of IgE-dependent allergic diseases (allergy of type I, Th2 lymphocytes dependent). However, numerous recent studies have indicated that they play an essential role in many other immunological and non-immunological processes. Infection with Toxoplasma gondii elicits the induction of a strong cell-mediated immunity characterized by a highly-polarized Th1 response, which can protect against allergy. Knowledge of the contribution of mast cells to Toxoplasma invasion is still limited, and the present article discusses aspects of the relationship between mast cells and T. gondii.
EN
In this review, we examine the state-of-the-art technologies (gas and liquid chromatography, mass spectroscopy and nuclear magnetic resonance, etc.) in the well-established area of metabolomics especially as they relate to protozoan parasites.
EN
Neosporosis was diagnosed ante-mortem in a litter of neonatally-infected dogs. Three pups developed weakness of limbs 7-9 weeks after birth. One of the dogs developed megaesophagus. Treatment with clindamycin improved clinical signs but did not eradicate the parasite. All 3 dogs were euthanized and viable N. caninum was isolated from the brains of all 3 dogs. Tissue cysts were found in the brain and muscles of dogs. The dam was bred again. Seven apparently healthy pups were born in the second litter. Six of the 7 pups from the second litter had no demonstrable N. caninum antibodies at 32 day of age. The seventh pup had high (1:1280) titer in the Neospora agglutination test and the titer remained stable at day 227 when the study was discontinued. The results suggest that the rate of congenital transmission of N. caninum decreased in the subsequent pregnancy.
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