Wyniki wyszukiwania - Biblioteka Nauki

1

Prognostic factors in traumatic brain injury and their association with outcome

100%

Kulesza B. , Nogalski A. , Kulesza T. , Prystupa A.

Journal of Pre-Clinical and Clinical Research

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2015

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tom 09

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nr 2

EN

Introduction. Traumatic brain injuries (TBI) are a real social problem, with an upward trend worldwide. TBI is the leading cause of death and disability, especially among young men. Each year in Europe, and also in Poland, 243 per 100,000 individuals suffer from TBI. Assessing prognosis after traumatic brain injury is very important in order to help clinicians to make a decision about the implementation of specific methods of treatment, and to make communication with the patient and the patient’s family easier. Objective. The objective of this review was to present prognostic factors, to assess outcomes within a short time after a moderate to severe traumatic brain injury, as well as to predict functional outcome. The most important independent variables were: age, Glasgow Coma Scale (GCS) motor score, pupil response, Marshall CT classification and traumatic subarachnoid haemorrhage. Other important prognostic factors included hypotension, hypoxia, glucose, coagulopathy, haemoglobin and category of CT characteristic, such as midline shift, mass lesion, basal cistern. Conclusions. Gender and intraventricular haemorrhage did not have predictive value. This subject needs much more research in the area of new prognostic factors which would be better associated with outcome after traumatic brain injury.

2

Carcinoembryonic antigen as a tumor marker in lung cancer – is it clinically useful?

100%

Agnieszka Okuła A. , Bożenna Karczmarek-Borowska B.

European Journal of Clinical and Experimental Medicine

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2018

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nr 1

53-59

EN

Introduction. Lung cancer is the most common cancer in the Western world. Annually there are approximately 1.8 million new cases worldwide. It is characterized by poor prognosis with a 5-year survival of 10-17% depending on the country. Contributing to this poor prognosis is a mainly late diagnosis, as well as a fairly frequent recurrence despite radical surgery. Over the years, scientists have been searching for a tumor marker that would be useful for patients with lung cancer. Aim. The aim of this study is to discuss the significance of carcinoembryonic antigen (CEA) in the diagnosis, prognosis of the disease course, and monitoring patients with lung cancer. Methods. Review of the literature using the PubMed database, Termedia, Via Medica and the key issue: carcinoembryonic antigen as a tumor marker in lung cancer. Conclusions. Serum CEA level can be a reliable complement to the diagnosis of lung cancer. It can be helpful in preoperative prediction of disease course and qualification for adjuvant treatment of non-small cell lung cancer especially adenocarcinoma. Trends and normalization of CEA during chemotherapy have an impact on progression-free survival and overall survival (OS) of patients. Various available publications describe CEA as a marker for metastatic lung cancer, which is the most specific for metastasis in the liver and brain.

3

Angiogenesis as a prognostic factor in invasive carcinoma of the uterine cervix

88%

Lenczewski A. , Terlikowski S. , Famulski W. , Sulkowska M. , Kulikowski M.

Folia Histochemica et Cytobiologica

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2001

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tom 39

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nr 2

4

CD44 as a prognostic factor in laryngeal cancer

88%

Woinska-Rojecka T. , Chodynicki S. , Chyczewski L. , Rzewnicki I.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

5

Prognostic risk factors in patients with interstitial lung disease referred for lung transplantation

75%

Jastrzebski D. , Kozielski J. , Nowak J. , Zielinska-Les I. , Ziora D. , Szulik B. , Wojarski J. , Zakliczynski M. , Zembala M.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

107-113

EN

The aim of the study was to identify prognostic factors that would differentiate patients with interstitial lung disease between those with and without a chance to survive until lung transplantation. A retrospective study was performed in patients with interstitial lung disease referred for lung transplantation between September 1999 and April 2005. The analysis included the demographic data, the time from referral to transplantation, the functional tests (FVC, FEV1, FEV1%VC, the PaO2 at rest and after oxygen supplementation via a nasal catheter), the count of NYHA functional classes, the left ventricular ejection fraction (EF), the distance covered during a 6-min walk test, and the pathogens in the respiratory tract. The patients were divided into two groups: Group 1 - lung transplant candidates who survived until the successful procedure and Group 2 - lung transplant candidates who died while on the waiting list. There were statistical differences between the two groups in PaO2 after supplementation (P=0.005), EF (P=0.002), and the 6-min walk distance (P=0.001). It appears that simple functional tests of the cardiorespiratory system may define survival of patients with interstitial lung disease waiting for lung transplantation.

6

Circulating immune complexes in advanced Hodgkin's disease: qualitative analysis and prognostic significance

75%

Tomasevic Z. , Jelic S.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

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nr 3

7

Molecular markers of apoptosis as prognostic indicators in cancer

75%

Walaszek Z. , Hanausek M.

Cellular and Molecular Biology Letters

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2000

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tom 05

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nr 2

8

Prognostic significance of epidermal growth factor receptor in surgically treated squamous cell lung cancer patients

75%

Niemiec J. , Kolodziejski L. , Dyczek S. , Gasinska A.

Folia Histochemica et Cytobiologica

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2004

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tom 42

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nr 2

9

Differences in oestrogen and progesterone receptors, HER-2 and p53 expression and proliferation in ductal breast cancers in relation to histopathological grade

63%

Zaslawski R. , Surowiak P. , Paluchowski P. , Dziegiel P. , Maciejczyk A. , Pudelko M. , Wojnar A. , Zabel M.

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tom 64

|

nr 1

9-15

EN

In case of breast cancer the grade of differentiation and expression of oestrogen and progesterone receptors falls within the first category of prognostic factors according to the College of American Pathologists. HER-2, p53 and Ki67 belong to the second category and their significance still awaits confirmation. The aim of the present study was to examine the relationship between the intensity of expression of oestrogen receptors (ER), progesterone receptors (PgR), HER-2, p53 and Ki67 in cells of ductal breast cancer of G1, G2 or G3 differentiation grade. In paraffin sections of 60 ductal breast cancers (20 cases in G1, 20 in G2 and 20 in G3), immunocytochemical reactions were performed to detect the expression of ER, PgR, HER-2, p53 and Ki67. Following a semi-quantitative appraisal of the preparations under examination, appropriate statistical tests were used to document significant relationships. We noted significant positive correlations between ER and PgR (the entire group studied, G1–3, and the G1 group), HER-2 and p53 (G2) and between p53 and Ki67 expression (G2). Significant negative correlations were found between ER and p53 (G1–3), PgR and p53 (G1–3, G1, G3) and between PgR and Ki67 (G1–3, G2). The studies performed demonstrated distinct relationships between the expression intensity of various proteins in tumour cells in relation to the grade of differentiation of the tumour. We also showed that a parallel determination of ER, PgR and p53 expression may carry high predictive value as to response to tamoxifen treatment.

10

Overexpression of the Her-2 oncogene in human breast cancer

63%

Corell B. , Horst-Sikorska W. , Fischer G. , Zoll B.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1991

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tom 39

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nr 2

11

Prognostic value of lymphocyte-related systemic inflammatory biomarkers in triple negative breast cancer

63%

Oraczewski R. K. , Czerniawska-Meler M. , Korzeniewicz M. , Kade G. , Kozielec Z. , Michalak M. , Król M. , Zdaniukiewicz A. , Bodnar L.

OncoReview

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2022

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tom 12

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nr 2

25-34

PL

Celem pracy było określenie wartości prognostycznej markerów stanu zapalnego u pacjentów z potrójnie ujemnym rakiem piersi. Zebrano dane dotyczące 143 chorych i oceniono używając testu chi-kwadrat, testu Wilcoxon–Mann–Whitney oraz regresji Coxa. Stwierdzono związek między wysokim poziomem stosunku neutrofilów do limfocytów, płytek do limfocytów, wskaźnikiem ogólnoustrojowej reakcji immunologiczno-zapalnej a miejscowym stopniem zaawansowania: guz (T3/T4) (P=0.0001, P=0.0198, P=0.0001), dodatnie regionalne węzły chłonne (P=0.0014, P=0.0075, P=0.0206). Wielowymiarowa analiza wykazała, że choroba rozsiana, gorszy stan sprawności oraz wysoki stosunek neutrofilów do limfocytów (Hazard ratio: 4.48 [2.05-9.80], P=0.0002; 2.23 [1.24-4.03], P=0.0010; 2.23 [1.24-4.03], P=0.0075) stanowią negatywne czynniki prognostyczne. Wysoki stosunek neutrofilów do limfocytów oraz gorszy stan sprawności stanowią niezależne negatywne czynniki prognostyczne.

EN

The aim was to evaluate inflammatory biomarkers as prognostic factors in patients with triple negativbreast cancer. We have collected data from 143 patients and evaluated using Chi-Squared test, Wilcoxon–Mann–Whitney test and Cox regression. We found a relationship between high neutrophil- to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index and local advancement features: tumor (T3/T4) (P = 0.0001, P = 0.0198, P = 0.0001), positive regional lymph nodes (P = 0.0014, P = 0.0075, P = 0.0206). In the multivariate analysis metastatic disease, worse performance status and high NLR (Hazard ratio: 4.48 [2.05–9.80], P=0.0002; 2.23 [1.24–4.03], P=0.0010; 2.23 [1.24–4.03], P=0.0075) were adverse prognostic factors. High neutrophil-to-lymphocyte ratio with worse performance status turned out an adverse independent prognostic factors.

12

Androgen receptors as a prognostic and predictive factor in breast cancer

63%

Agrawal A. K. , Jelen M. , Grzebieniak Z. , Zukrowski P. , Rudnicki J. , Nienartowicz E.

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tom 46

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nr 3

269-276

13

Nuclear maspin expression as a good prognostic factor in human epithelial ovarian carcinoma

63%

Sopel M. , Surowiak P. , Berdowska I.

Folia Morphologica

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2010

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tom 69

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nr 4

EN

Maspin, a protein belonging to the serpin superfamily, seems to exert tumour- -suppressive activity. Its significance in ovarian cancer prognosis is currently under investigation. In the present work, immunocytochemical maspin expression in 132 invasive epithelial ovarian carcinomas was assessed independently in the nucleus and cytoplasm, in correlation with histopathological and clinical data. Positive maspin expression was found in 117 cases: nuclear/cytoplasmatic in 71, exclusive nuclear in 29, and only cytoplasmatic in 17 cases. Cytoplasmatic maspin expression was positively correlated with tumour grade (p = 0.000), FIGO stage (p = 0.002), and distant metastases (p = 0.000) but exhibited no significant correlation with tumour type (p = 0.078). Nuclear maspin expression showed negative correlation with tumour grade (p = 0.025), FIGO stage (p = 0.05), distant metastases (p = 0.001), and cancer remission (p = 0.000) but showed no significant relationship with the patients’ age (p = 0.948) or cancer subtype (p = 0.261). Kaplan-Meier survival analysis showed that strong cytoplasmatic maspin expression was correlated with shorter disease-free survival (p = 0.000) whereas strong nuclear expression was correlated with longer survival (p = 0.000). In Cox regression analysis, low nuclear maspin expression (score 2 and 3) remained a significant independent prognostic factor (p = 0.001) with a relative death risk of 5.337. The obtained results suggest that maspin expression may be a significant marker in epithelial ovarian carcinoma prognosis with its nuclear expression being a good prognostic factor. (Folia Morphol 2010; 69, 4: 204–212)

14

Analysis of mutation in SPR and HTRA2 genes in patients with Parkinson’s disease

63%

Polrolniczak A. , Dorszewska J. , Florczak-Wyspianska J. , Owecki M. , Kozubski W.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

EN

Diagnosis of Parkinson’s disease (PD) is often problematic because clinically it can be difficult to distinguish idiopathic PD from the other extrapyramidal disorders. It is known, that PD is caused either by environmental and genetic factors . Genetic mutations are the cause of familial form of PD and include genes PARK1-PARK18. The etiology of sporadic PD (SPD) is still not clear, but it is currently assumed that genetic susceptibilities, may be involved. It is suggested, that in pathogenesis of the SPD beside SNCA and PARK2 genes, may be involved also SPR (sepiapterin reductase gene) [PARK3] and HTRA2 (HTRA serine peptidase 2 gene)[PARK13] genes. The HTRA2 gene, also known as Omi, was found to be associated with PD in German population. However, some studies have indicated that some variants of HTRA2 may not be related to PD. SPR gene, which is located in the PARK3 linkage region is inconsistently associated with a risk of PD but significance of mutations in this gene as well as HTRA2 in PD is still not clear. The aim of the study was the analysis of the frequency of T637A/G SPR as well G421T, G1195A and C1210T mutations in HTRA2 gene in Polish patients with PD and in control group. Peripheral blood was collected from 89 patients with PD clinical diagnosis (42F and 47M, the avr. age 62 ± 10.15 years), and from 113 healthy donors (79F and 7M, the avr. age 55.5 ± 9.54 years). Genomic DNA was isolated using standard protocols. Genotyping was performed by PCR/RFLP using specific primers and restriction enzymes (SsiI, MboII, MvaI, MspI) and sequencing. The SPR gene analysis detected T637A mutation in 3 (3%) PD patients compared to 2 (2%) persons in the control group. Moreover, mutations G421T and G1195A of HTRA2 gene have been identified in 3 (3%) [G421T – 1%, G1195A – 2%] patients with PD and none of controls. Analysis of C1210T HTRA2 mutation detected no mutated variant both in PD patients group and in control group. It was also observed that the stage of the disease was 1–2 in Hoehn and Yahr scale and response to L-dopa was good in patients with T637A SPR and G421T, G1195A HTRA2 mutations. It was also observed some tendency for depression manifestation in PD patients with T637A SPR mutation. It can be concluded, that mutations of SPR and HTRA2 genes probably may be one of the risk factor for manifestation of PD. Thus, the results of this study suggest that analysis of T637A SPR and G421T, G1195A HTRA2 genes mutations may be an additional diagnostic and prognostic factor in PD patients in the future.

15

Correlation between metallothionein [MT] expression and selected prognostic factors in ductal breast cancers

63%

Gomulkiewicz A. , Podhorska-Okolow M. , Szulc R. , Smorag Z. , Wojnar A. , Zabel M. , Dziegiel P.

Folia Histochemica et Cytobiologica

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2010

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tom 48

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nr 2

242-248

16

Novel prognostic molecular factors: a quantum leap in the field of chronic lymphocytic leukemia

63%

Zakrzewska E. , Pirog M. , Purkot J. , Giannopoulos K.

Folia Histochemica et Cytobiologica

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2017

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tom 55

|

nr 3

17

Application of tissue microarrays for receptor immunohistochemistry in breast carcinoma

63%

Glajcar A. , Kaczmarczyk K. , Szpor J. , Okon K.

Folia Histochemica et Cytobiologica

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2013

|

tom 51

|

nr 4

18

Survivin antiapoptotic gene expression as a prognostic factor in non-small cell lung cancer: in situ hybridization study

63%

Karczmarek-Borowska B. , Filip A. , Wojcierowski J. , Smolen A. , Pilecka I. , Jablonka A.

Folia Histochemica et Cytobiologica

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2005

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tom 43

|

nr 4

19

Loss of heterozygosity for Rb locus and pRb immunostaining in laryngeal cancer: a clinicopathologic, molecular and immunohistochemical study

51%

Pietruszewska W. , Klatka J. , Borzecki A. , Rieske P.

|

tom 46

|

nr 4

479-485

20

Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors

51%

Bojarska-Junak A. , Sieklucka M. , Hus I. , Wasik-Szczepanek E. , Kusz M. L. , Surdacka A. , Chocholska S. , Dmoszynska A. , Rolinski J.

Folia Histochemica et Cytobiologica

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2011

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tom 49

|

nr 1