Wyniki wyszukiwania - Biblioteka Nauki

1

Prognostic value of using neutrophil-lymphocyte ratio in patients with burn injury for the diagnosis of sepsis and bacteraemia

100%

Fuss J. , Voloboyeva A. , Poliovyj V.

Polish Journal of Surgery

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2018

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tom 90(5)

13-16

EN

Objective: Despite the progress in the treatment of burn injuries, the mortality rate among seriously ill patients still remains high nowadays. The main causes of fatal cases with extensive deep burns are generalized infectious complications, the major of which is sepsis. According to the authors, 25%–85% of those who died of burn injuries in later periods, died from sepsis. The frequency and severity of infectious complications in patients with burn injuries requires an accurate diagnosis of infection that will determine the tactics of therapeutic and surgical treatment of such patients (Di Lonardo A. et al., 1993). However, the clinical diagnosis of wound infection in patients with burn injuries is quite difficult. Materials and methods: The clinical material included 188 patients with burn injuries. The average age of those patients ranged from 20 to 59 years. Men - 98 (52.1%), women - 90 (47.9%). The survey was conducted from April 2014 to July 2016. Results: In our opinion, the strength of NLR (neutrophil-lymphocyte ratio) is the possibility of implementing this parameter simply by using already available biomarkers (neutrophil count and lymphocyte count). Therefore, this ratio is easy to integrate in clinical practice and cost effective. Conclusion: The application of NLR for the diagnosis of sepsis in patients with burn injuries is the option of choice, since its determination requires only a general blood test.

2

Wybrane markery laboratoryjne w rozpoznaniu i monitorowaniu zakażenia – cz. I

72%

Mowińska-Czosnek A. , Pleskot K.

Laboratorium - Przegląd Ogólnopolski

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2013

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tom nr 9-10

42--45

PL

Sepsa to jedno z najcięższych powikłań pozakaźnych u człowieka. Zgodnie z obowiązującą definicją posocznica to układowa reakcja zapalna organizmu na wniknięcie czynnika infekcyjnego. Cechuje się dużą dynamiką rozwoju objawów – od uogólnionej reakcji zapalnej do zagrażającego bezpośrednio życiu wstrząsu septycznego. Znaczące ryzyko powikłań, wysoka śmiertelność, a także wysokie koszty leczenia sprawiają, że duży nacisk kładzie się na wczesne rozpoznanie choroby i wdrożenie agresywnego leczenia.

EN

Sepsis is one of the most serious complications of infectious diseases in humans. Currently, according to a defined sepsis is a systemic inflammatory reaction of the body to penetrate infectious agent. It is characterized by high dynamics of development of symptoms – from the systemic inflammatory response to directly threatening the life of septic shock. Significant morbidity high mortality and high treatment costs, make a lot of emphasis is placed on early diagnosis and aggressive treatment implementation.

3

Increased circulating endocan in patients with cirrhosis: relation to bacterial infection and severity of disease

72%

Zuwala-Jagiello J. , Simon K. , Kukla M. , Murawska-Cialowicz E. , Gorka-Dynysiewicz J. , Grzybek E. , Pazgan-Simon M.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 2

4

Procalcitonin as an indicator of systemic response to infection in active pulmonary Wegener's granulomatosis

72%

Zycinska K. , Wardyn K. A. , Zielonka T. M. , Tyszko P. , Straburzynski M.

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nr 6

839-844

5

Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock

72%

Jedynak M. , Siemiatkowski A. , Mroczko B. , Groblewska M. , Milewski R. , Szmitkowski M.

Archivum Immunologiae et Therapiae Experimentalis

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2018

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tom 66

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nr 4

6

Effectiveness of hemoperfusion in treatment of patients with non-biliary moderately severe pancreatitis

72%

Oliynyk O. , Slifirczyk A. , Pereviznyk B. , Kushnarov W.

Health Problems of Civilization

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2018

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tom 12

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nr 3

EN

Background. Acute pancreatitis morbidity has been rising annually all around the world. In case of acute necrotic pancreatitis, the mortality reaches 40% in the majority of hospitals. The therapy is effective if the efferent methods involve complex therapy of this disease. One such method is hemoperfusion, i.e. extracorporeal blood purification, which is widely used in toxicology. The authors of the article used hemoperfusion in a complex therapy in patients with severe acute pancreatitis. The following research presents an evaluation of the results of hemoperfusion used in a complex therapy of patients with acute pancreatitis. Material and methods. The study involved 38 patients with acute non-biliary moderately severe pancreatitis who were treated at an intensive care unit of Ternopil University Hospital in Ukraine. 18 patients were treated following the protocol for treatment of acute pancreatitis. In 20 patients, this treatment was additionally combined with hemoperfusion. We determined the levels of amylase, diastase, procalcitonin, bilirubin, malonic dialdehyde, and diene conjugates in blood serum and the level of leukocytes in the blood. Results. The levels of procalcitonin, amylase, bilirubin, leukocytes number, malonic dialdehyde, and diene conjugates were stabilised in patients of both groups, but in those who received hemoperfusion demonstrated much better results. These were manifested by significantly better levels of the amylase, bilirubin, creatinine, urea, procalcitonin, malonic dialdehyde, and diene conjugates in patients who received hemoperfusion (p< 0.005) than in the other group undergoing standard drug therapy. Conclusions. Hemoperfusion can be used as an effective method in the complex treatment of patients with acute pancreatitis.

PL

Wprowadzenie. Corocznie na całym świecie obserwuje się w zrost zachorowalności na ostre zapalenie trzustki. W przypadku ostrego martwiczego zapalenia trzustki śmiertelność w większości szpitali osiąga 40%. Terapia jest skuteczna, jeśli metody odprowadzające obejmują kompleksową terapię tej choroby. Jedną z takich metod jest hemoperfuzja, tj. pozaustrojowa hemodializa krwi, szeroko stosowane w toksykologii. Autorzy artykułu zastosowali hemoperfuzję w kompleksowej terapii u pacjentów z ciężkim ostrym zapaleniem trzustki. Poniższe badania przedstawiają ocenę wyników hemoperfuzji stosowanej w kompleksowej terapii pacjentów z ostrym zapaleniem trzustki. Materiał i metody. W badaniu wzięło udział 38 pacjentów z ostrym, niezłośliwym i umiarkowanie ciężkim zapaleniem trzustki; leczonych w oddziale intensywnej opieki medycznej szpitala uniwersyteckiego na Ukrainie. Zgodnie z protokołem leczenia ostrego zapalenia trzustki leczono18 pacjentów. U 20 pacjentów leczenie to połączono dodatkowo z hemoperfuzją. Określono poziom amylazy, diastazy, prokalcytoniny, bilirubiny, dialdehydu malonowego i koniugatów dienowych w surowicy krwi oraz poziom leukocytów we krwi. Wyniki. Poziom prokalcytoniny, amylazy, bilirubiny, liczby leukocytów, dialdehydu malonowego i koniugatów dienowych były stabilizowane u pacjentów z obu grup, ale u tych pacjentów, u których włączono hemoperfuzję, wyniki były zdecydowanie lepsze. Przejawiały się one znacznie wyższym poziomem amylazy, bilirubiny, kreatyniny, mocznika, prokalcytoniny, dialdehydu malonowego i dienowych koniugatów u pacjentów, którym włączono hemoperfuzję hemoperfuzję (p <0,005) niż w drugiej grupie poddawanej standardowej terapii lekowej. Wnioski. Hemoperfuzja może być stosowana jako skuteczna metoda w kompleksowym leczeniu pacjentów z ostrym zapaleniem trzustki.

7

Inflammatory markers in patients after hematopoietic stem cell transplantation

72%

Sjoqvist C. , Snarski E.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 4

8

Determination of PCT on admission is a useful tool for the assessment of disease severity in travelers with imported Plasmodium falciparum malaria

72%

Righi E. , Merelli M. , Arzese A. , Siega P. D. , Scarparo C. , Bassetti M.

Acta Parasitologica

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2016

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tom 61

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nr 2

9

Efficacy of procalcitonin measurement in patients after total thyroidectomy due to medullary thyroid carcinoma

72%

Bolko P. , Manuszewska-Jopek E. , Michalek K. , Wasko R. , Jaskula M. , Sowinski J.

Archivum Immunologiae et Therapiae Experimentalis

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2003

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tom 51

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nr 6

10

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels septic patients

72%

Piechota M. , Banach M. , Irzmanski R. , Misztal M. , Rysz J. , Barylski M. , Piechota-Urbanska M. , Kowalski J. , Pawlicki L.

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nr 2

EN

The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80±84.65 pg/ml, 22.32±97.41 ng/ml, 128.51±79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.

11

Sepsis immunopathology: perspectives of monitoring and modulation of the immune disturbances

51%

Skirecki T. , Borkowska-Zielinska U. , Zlotorowicz M. , Hoser G.

Archivum Immunologiae et Therapiae Experimentalis

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2012

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tom 60

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nr 2