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Genetic aspects of Alzheimer's disease

100%

Zekanowski C. , Religa D. , Graff C. , Filipek S. , Kuznicki J.

Acta Neurobiologiae Experimentalis

2004

tom 64

nr 1

Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease

67%

Zekanowski C. , Wojda U.

Acta Neurobiologiae Experimentalis

2009

tom 69

nr 2

232-253

Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased rate of general aneuploidy and cell cycle reentry in the AD patients' brains, with area-specific pattern. In this review, we discuss the involvement of chromosome instability, genome damage and cell cycle impairment in AD pathology.