W pracy przedstawiono badania wpływu modyfikacji struktury Mg (Glicfosf) argininą i glicyną na proces wchłaniania jonów Mg2+. Dokonano oceny wpływu wybranych nośników: poliwinylopirolidonu (PVP) i fosfatydylocholiny (PC45) na proces wchłaniania jonów Mg2+ in vitro ze stałych rozproszeń. Wykazano pozytywny wpływ modyfikacji struktury aminokwasami: glicyną i argininą i nośników dodanych do stałych rozproszeń na proces wchłaniania jonów magnezowych.
EN
The results of the research on influence of modification in the structure of Mg (Glicfosf) with arginine and glycine on the process of Mg2+ ion absorption were presented in this paper. The evaluation of the influence of selected carriers: polyvinylpyrrolidone (PVP) and phosphatidylcholine (PC 45) on the absorption process of Mg2+ ions in vitro from solid dispersions was completed. The results of these investigations showed positive influence of the modification by amino acids such as arginine and glycine as well as the addition of carriers to solid dispersion on the absorption of Mg ions.
The distribution of Mg and Ca contents in sera was assessed after the administration of magnesium and magnesium-calcium preparations in 28 normal cows. The experiment was carried out on four groups of animals. The following were evaluated: 25 per cent magnesium sulfu- ricum, 25 per cent magnesium sulfuricum combined with 25 per cent calcium borogluconatum, 20 per cent magnesium gluconicum and Calcigluc, ie. magnesium-calcium compound containing chlorides and gluconates. The above preparations, depending on the mineral contents, were given in the form of intravenous infusions, subcutaneous or intramuscular injections at the rate commonly used or recommended. For the purposes of the examination, the samples of blood were taken before administering the preparations; at 15 min; then at 1, 2, 4, 8, 12, 24 and 48 hours. Comparative magnesium and calcic preparations curves indicated that magnesium gluconicum was more useful than magnesium sulfate. After the magnesium gluconicum infusion an increase of Mg level was observed which persisted in the blood for 12 hours. A similar prolonged effect could be achieved by means of magnesium sulfate given simultaneously i.v. and i.m. Recommended doses of 20% magnesium gluconate (0,5 ml per 1 kg of body weight) were relatively small and could be even doubled without any direct side effect. The addition of calcium sulfate to magnesium negatively influenced increase of Mg concentration in the serum, which makes the drug safer and enables the use of high doses, though we do not know much about its final biological effect.