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1 Medycyna Weterynaryjna

1 1996

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Badania nad embriotoksycznoscia preparatu Inosine pranobex w probie biologicznej na zarodkach kurzych

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Borzemska W. , Karpinska E. , Kosowska G. , Szeleszczuk P. , Binek M. , Malicka E. , Malec H. , Niedziolka J.

1996

tom 52

nr 12

778-780

A modified biological method using chicken embryos for the assessment of toxicity of the drug Inosine pranobex (made by Ewopharm - group I or Polfa - group II) was developed. The drugs at a dose of 50 mg/kg of body weight were injected into the while of an egg of embryos at the 6th day of embryogenesis. No teratogenic effects were found. Both drugs showed significant differences in embryotoxicity compared with the control group in favour of the drug made by Ewopharm. The differences were associated with hatching indices (59.88% in group I and 37.9% in group II), the deviation of the hatching diagram towards its delay and the prolongation of hatching time from pipping the shell to the disengagement from it. It was found that the drug of higher toxicity caused a delay of the process of embryogenesis; oedema of livers and kidneys were noticed as well. In chicken of group II a significant increase of alkaline phosphatase in the blood was also observed.