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Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5' -end lipophilic modification

100%

Kobylanska A. , Pluskota E. , Swiatkowska M. , Wojcik M. , Cierniewska-Cieslak A. , Krakowiak A. , Boczkowska M. , Pawlowska Z. , Okruszek A. , Koziolkiewicz M. , Cierniewski C. S. , Stec W. J.

nr 3

A series of conjugates containing residues of lipophilic alcohols covalently bound to 5'-end of oligodeoxyribonucleotides targeted against human plasminogen activator inhibitor (PAI-1) mRNA was synthesized via the oxathiaphospholane approach. The highest anti-PAI-1 activity in EA.hy 926 endothelial cell cultures was found for conjugates containing menthyl or heptadecanyl groups linked with an oligonucleotide complementary to a segment of human PAI-1 mRNA. The phosphodiester antisense oligonucleotides, which otherwise exhibit only limited anti-PAI-1 activity, were found to be more active than phosphorothioate oligonucleotides when conjugated to lipophilic alcohol residues. For menthyl conjugates an evidence of antisense mechanism of inhibition was found.

LAM cells biology and lymphangioleiomyomatosis

67%

Grzegorek I. , Drozdz K. , Podhorska-Okolow M. , Szuba A. , Dziegiel P.

nr 1

The metabolic syndrome – an ongoing story

59%

Duvnjak L. , Duvnjak M.

nr 7