Wyniki wyszukiwania - Biblioteka Nauki

1

Granular cell tumor of the neurohypophysis – a case report

100%

Rafał Dziedzic R. , Natalia Leksa N. , David Aebisher D. , Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

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2019

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nr 4

378-380

EN

Introduction. The granulomatous tumor (GCT) is formed from the posterior pituitary (neurohypophysis) or its pedicle. The location of such a tumor in the region of the Turkish or supra saddle is a very rare matter. Aim. To present a case report. Description of the case. This article describes the case of a 39-year-old man admitted to the Department of Neurosurgery with a MR-diagnosed head tumor in the suprasellar area growing out of the pituitary funnel. The tumor appeared to be an epileptic fit. Conclusion. Herein we described a clinical case of granulomatous tumor. GCTs in the pituitary nerves are benign tumors, which makes treatment dependent on the individual case. After the operation, the H-P study showed a granulomatous tumor (GCT) of the posterior pituitary gland.

2

Activity of monoamine oxidase in the hypothalamus of ewes after protracted exposure to gamma radiation

88%

Pastorova B. , Stanikova A. , Sopkova D. , Maracek I. , Bugarsky A. , Danko J.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 2

3

A new morphometric method for the sella turcica and the hypophyseal fossa and its clinical relevance

75%

Venieratos D. , Anagnostopoulou S. , Garidou A.

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nr 4

240-247

EN

The sella turcica and the hypophyseal fossa should be considered different entities, the latter being part of the former. Their morphology and dimensions correlate to some extent with those of the contained pituitary gland and have, for this reason, attracted the interest of anatomists and radiologists. With the application of MRI, however, these data are of limited use in the diagnosis of pituitary disorders, although they remain valuable with regard to a microsurgical approach to the hypophysis. The proposed morphometric method was applied to 20 dry skulls. We first made casts of the corresponding sellae. Their volumes were then measured by immersion. The frontal section of each hypophyseal fossa was obtained through its deepest point and magnified. The Cartesian co-ordinates of the contour of the section were used to evaluate the corresponding area and centroid. The volume of each fossa was finally obtained by the use of Pappus’ theorem applied to solids of rotation. The volumes of the sellae obtained as above ranged from 460 mm³ to 1570 mm³ with a mean value of 835 mm³. These figures are comparable to those reported from previous authors. To our knowledge the method described has enabled a close approximation of the volumes of the hypophyseal fossae to be made for the first time. These volumes ranged from 24 mm³ to 300 mm³, with a mean value of 157 mm³. Similar numerical methods might be applicable in vivo by the use of MR imaging.

4

Decreased expression of survivin 2B in human pituitary adenomas. A preliminary study

75%

Waligorska-Stachura J. , Sawicka-Gutaj N. , Zabel M. , Liebert W. , Gut P. , Czarnywojtek A. , Ruchala M.

Folia Histochemica et Cytobiologica

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2017

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tom 55

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nr 1

5

Preoperative assessment of the risk of cavernous ICA injury in endoscopic transsphenoidal surgery

75%

Berger G. , Łukasiewicz A. , Grinevych V. , Milewska A. J. , Tarasów E.

Polish Journal of Surgery

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2020

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tom 92(2)

1-7

EN

In endoscopic endonasal transsphenoidal procedures, ICA injury occurs in up to 3.8% [1]. The highest hazard of injury is in case of contact between the ICA and pituitary gland, during opening of the dura. Preoperative imaging, i.e. CTA, MRA, supports objectively intraoperative techniques of imaging. CTA as well as MRA are essential to access anatomic details in variability of cavernous segments of the ICA (C4 ICA). The aim of the study was to measure the space between Internal Carotid Arteries and distances between the pituitary gland and ICA on both sides. Anatomic relations between left and right ICAs were accessed on CTA (coronal scans) at levels: A – The most concave point of the C4–C5 bend; B – The most convex point of the C4 bend; C – The C4 posterior ascending portion. Distances between pituitary gland and ICAs were measured on both sides on MRA (axial scans): A’ – The most concave point of C4–C5 bend; B’ – The most convex point of the C4 bend. The Statistica 13 (StatSoft) software was used for the statistical analysis. The Mann-Whitney U test was applied to determine differences between the groups. To analyze the strength of correlations between the quantitative variables, Spearman’s rank correlation coefficients were calculated. The results were considered statistically significant at the level of P < 0.05. Distance reduction was shown between pituitary glands and cavernous segment (C4) of ICAs on both sides, which is related to age. This has impact on surgical planning and highlights the risk of intraoperative injury of ICAs.

6

Expression of leptin and long form of leptin receptor genes and proteins in pituitary of cyclic and pregnant pigs

75%

Siawrys G. , Kaminski T. , Smolinska N. , Przala J.

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tom 58

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nr 4

EN

Leptin is a multifunctional regulator in numerous tissues, including the pituitary. It is not known, whether the porcine pituitary is a source of leptin synthesis and possesses the leptin receptor protein. It is also unknown, if a relationship exists between expression levels of these proteins in the pituitary and physiological status of sows. Therefore, the aim of the study was 1] to examine, by Western-blotting analysis, the expression levels of leptin and the long form of leptin receptor (OB-Rb) in the porcine anterior (AP) and posterior (NP) pituitary gland during mid- and late-luteal phases of the oestrous cycle (days 10 - 12 and 14 - 16) as well as during two stages of early pregnancy (days 14 - 16 and 30 - 32); and 2] to localise, using in situ hybridisation method (ISH), the expression of leptin and OB-Rb genes in the pituitary gland in the above mentioned stages of the cycle and pregnancy. Western-blotting analysis showed that leptin protein expression in AP was higher in the late-luteal phase than in the mid-luteal phase, while OB-Rb protein expression in both lobes was higher in the mid-luteal phase. In turn, during pregnancy leptin protein content in AP and OB-Rb protein content in NP were more pronounced on days 14 - 16 than on days 30 - 32. Comparison of leptin and OB-Rb protein expression levels in AP between the mid-luteal phase and two periods of pregnancy showed, respectively, stimulation of leptin protein and inhibition of OB-Rb protein expressions during both examined stages of pregnancy. Taking AP from late-luteal phase as the point of reference, it was revealed stimulation of leptin expression during earlier period of pregnancy, whereas on days 30 - 32 of pregnancy both the hormone and its receptor expressions were diminished. In turn, comparison of leptin and OB-Rb protein expression levels in NP between the late-luteal phase and days 14 - 16 or 30 - 32 of pregnancy showed inhibition of leptin protein expression and stimulation of OB-Rb protein expression during pregnancy. Moreover, ISH studies localised leptin and OB-Rb mRNAs expression in the cells of AP as well as NP tissue during the two stages of the cycle and pregnancy. In conclusion, our findings suggest that leptin is produced within the pituitary in the pig and may participate in auto/paracrine manner in the regulation of this gland function during the luteal phase of the oestrous cycle and early pregnancy.

7

The involvement of catecholamines in the pituitary release of luteinizing hormone [LH] and prolactin [PRL] in progesterone [P4] - treated gilts

75%

Siawrys G. , Przala J.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

8

Tranformation of a human mixed GH-PRL adenoma cell population in response to long-term bromocriptine treatment

75%

Bacsy E. , Fazekas I. , Slowik F. , Pasztor E. , Czirjak S.

Folia Histochemica et Cytobiologica

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1997

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tom 35

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nr 2

9

The influences of GnRH, oxytocin and vasoactive intestinal peptide on LH and PRL secretion by porcine pituitary cells in vitro

75%

Bogacka I. , Siawrys G. , Okrasa S. , Kaminski T. , Przala J.

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nr 3

EN

The aim of the present study was to evaluate the possible direct effects of GnRH, oxytocin (OT) and vasoactive intestinal peptide (VIP) on the release of LH and PRL by dispersed porcine anterior pituitary cells. Pituitary glands were obtained from mature gilts, which were ovariektomized (OVX) one month before slaughter. Gilts randomly assigned to one of the four groups were treated: in Group 1 (n=8) with 1 ml/100 kg b.w. corn oil (placebo); in Group 2 (n=8) and Group 3 (n=8) with estradiol benzoate (EB) at the dose 2.5 mg/100 kg b.w., respectively, 30-36 h and 60-66 h before slaughter; and in Group 4 (n=9) with progesterone (P4) at the dose 120 mg/100 kg b.w. for five consecutive days before slaughter. In gilts of Group 2 and Group 3 treatments with EB have induced the negative and positive feedback in LH secretion, respectively. Isolated anterior pituitary cells (106/well) were cultured in McCoy's 5a medium with horse serum and fetal calf serum for 3 days at 37°C under the atmosphere of 95% air and 5% CO2. Subsequently, the culture plates were rinsed with fresh McCoy's 5A medium and the cells were incubated for 3.5 h at 37°C in the same medium containing one of the following agents: GnRH (100 ng/ml), OT (10-1000 nM) or VIP (1-100 nM). The addition of GnRH to cultured pituitary cells resulted in marked increases in LH release (p<0.001) in all experimental groups. In the presence of OT and VIP we noted significant increases (p<0.001) in LH secretion by pituitary cells derived from gilts representing the positive feedback phase (Group 3). In contrast, OT and VIP were without any effect on LH release in Group 1 (placebo) and Group 2 (the negative feedback). Pituitary cells obtained from OVX gilts primed with P4 produced significantly higher amounts (p<0.001) of LH only after an addition of 100 nM OT. Neuropeptide GnRH did not affect PRL secretion by pituitary cells obtained from gilts of all experimental groups. Oxytocin also failed to alter PRL secretion in Group 1 and Group 2. However, pituitary cells from animals primed with EB 60-66 h before slaughter and P4 produced markedly increased amounts of PRL in the presence of OT. Neuropeptide VIP stimulated PRL release from pituitary cells of OVX gilts primed with EB (Groups 2 and 3) or P4. In contrast, in OVX gilts primed with placebo, VIP was without any effect on PRL secretion. In conclusion, the results of our in vitro studies confirmed the stimulatory effect of GnRH on LH secretion by porcine pituitary cells and also suggest a participation of OT and VIP in modulation of LH and PRL secretion at the pituitary level in a way dependent on hormonal status of animals.

10

Somatostatin receptors in human adrenal gland tumors - immunohistochemical study

63%

Pisarek H. , Stepien T. , Kubiak R. , Pawlikowski M.

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2008

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tom 46

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nr 3

345-351

11

Expression of Npc1 in glial cells corrects sterility in Npc1 mice

63%

Donohue C. , Marion S. , Erickson R. P.

Journal of Applied Genetics

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2009

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tom 50

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nr 4

385-390

EN

Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npcl protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selective expression of Npcl corrects sterility in GFAP-Npc1E, Npcl-/- mice. Counts of acidophils in the pituitary of GFAP-Npc1E,Npc1-/-- mice, as compared to Npc1-/- mice, and measurements of dopamine D2 receptor (DRD2) mRNA in the pituitary, suggest mechanisms for fertility enhancement. We conclude that the correction of sterility in GFAP-Npc1E, Npc1-/- mice is a result of restoring hypothalamic control of the pituitary.

12

Does repeated gold-nanoparticles administration affect pars distalis hormonal and folliculo-stellate cells in adult male albino rats?

63%

Omar A. I. , Kamar S. S.

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nr 2

13

Pituitary microsomal autoantibodies in patients with childhood-onset combined pituitary hormone deficiency: an antigen identification attempt

63%

Ziemnicka K. , Gut P. , Golab M. , Dworacki G. , Wrotkowska E. , Stajgis M. , Katulska K. , Rabska-Pietrzak B. , Obara-Moszynska M. , Niedziela M. , Budny B. , Kaluzna M. , Wasko R. , Ruchala M.

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2016

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tom 64

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nr 6

14

Neurosecretory and histological changes in hypothalamus and neural zone of pituitary gland in rats following hydrocortisone and adrenaline administration

63%

Ficek W.

Acta Biologica Cracoviensia. Series Zoologia

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1989

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tom 31

15

Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas

63%

Pawlikowski M.

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2006

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tom 44

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nr 3

16

The effects of nicotine in combination with antidopaminergic drugs on the maturational gonadotropin [GTH2] secretion from perifused common carp [Cyprinus carpio L.] pituitary glands

63%

Mikolajczyk T. , Epler P. , Sokolowska-Mikolajczyk M. , Breton B. , Chyb J. , Cwioro E.

Polskie Archiwum Hydrobiologii

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1996

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tom 43

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nr 3

17

Effect of compound 48-80 on the thalamic mast cells, serotonin level and corticosterone secretion in rats

63%

Bugajski J. , Bugajski A. J. , Chlap Z. , Borycz J.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 4

18

Control of the LH surge mechanism in the female pig

63%

Elsaesser F. , Parvizi N. , Foxcroft G. R.

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1992

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tom 43

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nr 1

19

Immunohistochemical demonstration of nitric oxide synthase [NOS] in the normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas

63%

Pawlikowski M. , Winczyk K. , Jaranowska M.

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nr 2

20

Immunohistochemical detection of dopamine D2 receptors in human pituitary adenomas

51%

Pawlikowski M.

Folia Histochemica et Cytobiologica

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2010

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tom 48

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nr 3