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Neonatal pinealectomy in rats — a simple micro-suction technique

100%

Pawlicki B. , Henry B. M. , Tomaszewski K. A. , Gajda M. , Brzozowska I. , Walocha J. A. , Skowron-Cendrzak A.

tom 57

nr 1

The influence of pinealectomy and single dose of melatonin administered at different times of day on serum T3 and T4 concentrations in rats

84%

Kniazewski B. , Ostrowska Z. , Zwirska-Korczala K. , Buntner B.

Acta Physiologica Polonica

1990

tom 41

nr 7

Kniażewski В., Ostrowska Z., Żwirska-Korczala K., Buntner B.: The influence of pinealectomy and single dose of melatonin administered at different times of day on serum T₃ and T₄ concentrations in rats. Acta Physiol. Pol. 1990, 41 (6): 116-125. The influence of pinealectomy and melatonin administration on the levels of total T₃ and T₄ plasma levels were determined by RIA method. The results of hormonal measurements were evaluated by means of Student’s t-test, and the diurnal rhythm by cosinor method. It has been established that pinealectomy disturbs the T₃ diurnal rhythm and caused marked changes in T₄ levels during the 24 hours. Exogenous melatonin does not influence the thyroid function during the light phase. During the dark phase, however, its inhibitory effect is prevalent in pinealectomized rats, and the stimulating in sham operated rats.

Pinealectomy and pineal hormones modify cytochrome P450-dependent monooxygenase system in rat liver

84%

Plewka A. , Kaminski M.

Polish Journal of Environmental Studies

1998

tom 07

nr 3

The cytochrome P450-dependent liver monooxygenase system is influenced by many endocrine glands. The components of the system show circadian rhythmicity and therefore their activities change during the day. This may suggest that the pineal gland, whose activity is strongly related to the external environment, influences this metabolic system. A growing interest in melatonin used as a nonprescription drug that inhibits aging and cures various diseases prompted us to investigate the influence of pineal hormones on the liver's metabolic system. The aim of this study was to evaluate the effect of pinealectomy, melatonin, or serotonin on the cytochrome P450-dependent monooxygenase system. The experiment was performed on sexually mature male Wistar rats. The rats were divided as follows: a control group, pinealectomized rats, melatonin-treated rats, and seroto- nin-treated rats. Pinealectomy was done 14 days before decapitation. The isolated microsomal fraction was assayed for the activity of cytochrome P450-dependent monooxygenase system and for the activity of the enzymatic system, which non-obligatorily cooperates with the MFO system. Both pinealectomy and prolonged administration of melatonin or serotonin modified the activity of the mixed function oxidase system. In all experimental groups the components of microsome electron-transport chain I were inhibited. In microsome electron-transport chain II only melatonin and serotonin produced an inhibitory effect, while pinealectomy did not affect cytochrome b5 and NADH-cytochrome b5 reductase. 4-Aminopyrine N-deme- thylase and aniline hydroxylase did not alter either after pinealectomy or melatonin treatment (only a decreasing tendency was noted). In contrast, serotonin treatment decreased these activities significantly.