Wyniki wyszukiwania - Biblioteka Nauki

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In silico Prediction of Anti-bacterial Potentials of Some Synthesized Sulfonamide Compounds

100%

Ikpa C. B. C. , Ikezu U. M.

World News of Natural Sciences

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2024

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tom 55

87-101

EN

Overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making drug treatment ineffective. This study aimed at screening some sulphonamide compounds in other to recommend new anti-bacteria drugs with better efficacy and lower toxicity. The ten (10) sulfonamide compounds were screened for their antibacterial activities against medically important gram (-) and gram (+) bacterial strains, namely, Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Bacillus cereus (B. cereus) and Staphylococcus aureus (Staph aureus). The antibacterial activities have been determined by in silico molecular docking of the ten (10) sulphonamide compounds on the targeted site of the organism`s protein. Among the tested compounds, it was found that ciprofloxacin was the most potent against E. coli with the highest binding affinity (-13.17 kcal/mol), while compounds; 3-(3H-indol-3-yl)-2-[(phenylsulfonyl)amino] propanoic acid (1906; -12.93 kcak/mol), {[(4-methylphenyl)sulfonyl]amino}-3-methylbutanoic acid (1909; -12.83 kcal/mol) and 3-(4-hydroxyphenyl)-2-[(phenylsulfonyl)amino]propanoic acid (1902; -12.48 kcal/mol) gave better binding scores than ciprofloxacin (-12.25 kcal/mol) with Pseudomonas aeruginosa. On the binding with Bacillus aereus protein, 2-[(phenylsulfonyl)amino]-3-sulfanylpropanoic acid (1904; -15.54 kcal/mol), 3-(4-hydroxyphenyl)-2-[(phenylsulfonyl)amino] propanoic acid (1902; -15.46 kcal/mol) and 3-(4-hydroxyphenyl)-2-{[(4methylphenyl)sulfonyl]anino} propanoic acid (1901; -15.45 kcal/mol), showed better binding affinity than cipro (-15.36 kcal/mol), while ciprofloxacin gave the highest binding affinity (-12.08 kcal/mol) with Staphylococcus aureus protein (3G75) when compared to the analysed sulfonamide compounds. The analysed 10 sulfonamide compounds showed potential drug candidates by obeying all the physicochemical parameters that qualifies a compound to be used as drug and therefore, can be clinically use for the treatment of diseases caused by the named organisms.

2

DEVELOPMENT OF BIODEGRADABLE PACKAGING FILMS AND EDIBLE COATINGS FOR FOOD PRODUCTS BASED ON COMPOSITE MATERIALS

86%

Kuprina E. E. , Yakkola A. N. , Manuylov A. N. , Kabysh O. , Zhirkova M. G. , Zhernyakova A. V. , Shmelkova M. A. , Vitalyevich T. S. , Stepanov A.

Progress on Chemistry and Application of Chitin and its Derivatives

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2020

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tom 25

124 - 131

EN

Plastic is undoubtedly the most convenient type of packaging, but at the same time it is not ecologically friendly. The widespread use of packaging materials all over the world makes us think more and more about the harm of plastic to the environment and humans. It does not decompose in natural conditions and accumulates in huge quantities, because it is mostly used as a single-use packaging. Therefore, the development of environmentally friendly biodegradable edible films and coatings is relevant. Edible food packaging is an important step in food production and one of the innovative directions of food packaging development. This article presents materials on the development of the formulation and manufacturing technology of new composite materials based on sodium alginate and chitosan for the production of edible coatings and films. The results of the physical, chemical and bactericidal properties of these materials are presented.

3

Seasonal variations of physicochemical characteristics of water from River Wupa, Abuja, Nigeria

72%

Opaluwa O. D. , Marcus N. D. , Adano A. J.

World News of Natural Sciences

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2024

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tom 56

45-57

EN

Seasonal variation in the quality of water from River Wupa, Abuja, Nigeria was studied by collecting sixty water samples in both dry and wet seasons which were analyzed using standard methods. The respective results for in dry and wet seasons were pH (7.13±0.09, 7.31±0.06), temperature (21.51±0.51, 27.66±0.49 ⁰C), EC (247.19±46.21, 152.43±17.76 µS/cm), TDS (156.80±39.74, 75.39±9.23 mg/dm3), TSS (33.38±14.12, 333.85±43.45 mg/dm3), turbidity (26.20±13.04, 361.51±52.89 NTU), alkalinity (34.49±4.12, 29.31±3.78 mg/dm3), DO (7.73±0.29, 8.95±0.87 mg/dm3), BOD (17.00±4.90, 15.70±2.98 mg/dm3), COD (40.36±14.01, 28.28±8.18 mg/dm3), hardness (33.74±2.10, 34.82±3.82 mg/dm3), sulphate (41.09±1.01, 28.82±1.05 mg/dm3), nitrate (12.12±2.02, 12.23±1.78 mg/dm3), nitrite (0.08±0.02, 0.06±0.02 mg/dm3), phosphate (2.09±0.33, 2.15±0.35 mg/dm3) and chloride (40.96±3.53, 32.23±3.82 mg/dm3). Correlation results shows that during the dry season there is a strong and positive correlation between (EC and TDC, r =0.910), (TSS and Turbidity, r = 0.976), (TSS and BOD, r = 0.945), (TSS and COD, r = 0.912), (Turb and BOD, r = 0.868), (Turbidity and COD, r = 0.820), (BOD and COD, r = 0.979), (pH and nitrite, r = 0.750) (pH and Cl, r = 0.737), (TSS and Cl, r = 0.748) and (Turb and Cl, r = 0.761). During the wet season strong and positive correlation is between (EC and TDS, r = 0.879), (BOD and COD, r = 0.756) and (Turbidity and sulpate, r = 0.730). Results for all parameters were below the limits recommended by NSDWQ except for turbidity, DO and phosphate, also in both seasons there was no significant difference for all parameters except for turbidity and COD. It is concluded that the variation in these two parameters is attributable to runoffs from farmlands and direct discharge of domestic and industrial effluent during the wet season and the strong and positive correlation indicates that the pollutants that affect water quality parameters come from the same sources.

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DEVELOPMENT OF BIODEGRADABLE POLYSACCHARIDE-PROTEIN EDIBLE GEL COAT WITH ANTIMICROBIAL PROPERTIES FOR FOOD PRODUCTS

58%

Kuprina E. E. , Yakkola A. N. , Manuylov A. N. , Kiprushkina E. I. , Shestopalova I. A. , Demidov P. I.

Progress on Chemistry and Application of Chitin and its Derivatives

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2021

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tom 26

148-161

EN

Food edible coatings are an important milestone in food production and one of the innovations in food packaging development. This article presents materials on the development of the formulation and technology for the manufacture of a novel composite coating based on sodium alginate, chitosan and protein hydrolysate obtained by the electrochemical method of double extraction from cod processing waste to obtain edible coatings for semi-finished fish products. Furthermore, the physicochemical, physical, mechanical and microbiological properties of this material are described.