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1
Resorcinolic lipids - disturb or stabilize biological membranes? Molecular dynamics simulations
100%
Siwko M. E. , Marrink S. J. , Kozubek A. , Mark A. E.
Cellular and Molecular Biology Letters
|
2005
|
tom 10
|
nr Suppl.
2
Elastic properties of closed layered membranes and equilibrium shapes of phospholipid vesicles
100%
Svetina S. , Zeks B.
Biophysics of Membrane Transport
|
1992
|
tom 11
|
nr 2
3
Content available remote The mystery of reactive oxygen species derived from cell respiration.
86%
Nohl H. , Gille L. , Staniek K.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 1
223-229
EN
Mitochondrial respiration is considered to provide reactive oxygen species (ROS) as byproduct of regular electron transfer. Objections were raised since results obtained with isolated mitochondria are commonly transferred to activities of mitochondria in the living cell. High electrogenic membrane potential was reported to trigger formation of mitochondrial ROS involving complex I and III. Suggested bioenergetic parameters, starting ROS formation, widely change with the isolation mode. ROS detection systems generally applied may be misleading due to possible interactions with membrane constituents or electron carriers. Avoiding these problems no conditions reported to transform mitochondrial respiration to a radical source were confirmed. However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/bc1 redox complex such that ROS formation became possible.
4
Content available remote Interactions of sialic acid with phosphatidylcholine liposomes studied by 2D NMR spectroscopy
86%
Timoszyk A. , Latanowicz L.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 4
539-546
EN
Biological membranes are complex systems which have attracted scientific interest for a long time and for various reasons. The sialic acid-liposome interactions at the molecular level depend on their hydro-lipophilic characteristics. The aim of the present study was to investigate the changes of conformation of the phospholipid (1,2-Diacyl-sn-glycero-3-phosphocholine) and sialic acid (2,8-(N-acetylneuraminic acid)) molecules and the type of interactions induced by the sialic acid molecules on membrane-like systems (liposomes) by 2D NMR (TOCSY, HETCOR, ROESY). The nature of the interaction of sialic acid with the model membrane depends on the structure of the phospholipid headgroups and the hydration of membrane. In ROESY spectra was observed the absence of dipole-dipole couplings within the choline head, between headgroups and glycerol, and between glycerol and fatty acid chains. It indicates an increase of the membrane dynamics in the presence of sialic acid. Moreover, the conformation of sialic acid molecule is changed in the presence of liposomes, which depends on stereochemistry of the chemical groups of the carbon atoms C7 and C8, and oxygen O8. The observed differences between the ROESY spectra of free and liposome bound sialic acid may be a consequence of a changed orientation of the pyranose ring from trans to gauche in the presence of liposomes. The sialic acid penetrate into the phospholipid bilayer to a sufficient depth to allow the dipole interaction. The present result that the correlation signal was found only between the methyl protons from the acetyl group of sialic acid and the methylene tail of phospholipid molecule in the ROESY spectrum indicates that the opposite end of the sialic acid molecule stays in the aqueous phase without interacting with membrane molecules.
5
The protective role of flavonoids against toxic factors on phospholipid membranes
86%
Gabrielska J. , Soczynska-Kordala M.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
6
Effect of some biologically active quaternary ammonium salts on planar phospholipid membranes
86%
Sarapuk J. , Gabrielska J. , Przestalski S.
Polish Journal of Environmental Studies
|
1992
|
tom 01
|
nr 1
EN
The effect of some biologically active amphilic quaternary ammonium chlorides (QA) on properties of bimolecular planar membranes (BLM) formed of lipids extracted from bovine erythrocytes was studied. Ammonium salts differed in the alkyl chain length or in the non-methylene group incorporated between the hydrocarbon chain and the polar head of a molecule. It was found that in the case of a series of QA of general structure (CH3)3N+CH2OCnH2n+1 (n=4, 10, 12, 14, 16 and 18) there exists a maximal interaction between QA and BLM for QA with n=16. It was also found that the introduction of different functional groups, between the nitrogen atom and the alkyl chain of the molecule significantly changed the interaction between ammonium salts and lipid membranes. The observed changes are explained in terms of changed amphiphilic properties of the molecule.
7
Phospholipid monolayer and liposome application in the determination of the photophysical characteristics of MC 540
86%
Sikurova L.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 2
8
The mystery of reactive oxygen species derived from cell respiration
86%
Nohl H. , Gille L. , Staniek K.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 1
EN
Mitochondrial respiration is considered to provide reactive oxygen species (ROS) as byproduct of regular electron transfer. Objections were raised since results ob­tained with isolated mitochondria are commonly transferred to activities of mito­chondria in the living cell. High electrogenic membrane potential was reported to trigger formation of mitochondrial ROS involving complex I and III. Suggested bioenergetic parameters, starting ROS formation, widely change with the isolation mode. ROS detection systems generally applied may be misleading due to possible interactions with membrane constituents or electron carriers. Avoiding these prob­lems no conditions reported to transform mitochondrial respiration to a radical source were confirmed. However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/&C1 redox complex such that ROS for­mation became possible.
9
Blocking effect of long-chain anionic amphiphiles on calcium ion release from liposomal membrane influenced by n-methyl-n-tetradecyl-morpholinium bromide and its mixture with alkylsulphonates
72%
Kuczera J. , Kral T. E.
Biophysics of Membrane Transport
|
1994
|
tom 12
|
nr 2
10
Comparison of the interaction of diphenyltin and triphenyltin chlorides with phospholipid bilayers
72%
Rozycka-Roszak B. , Zylka R. , Przestalski S.
Cellular and Molecular Biology Letters
|
1997
|
tom 02
|
nr 1
EN
The interaction of diphenyltin and triphenyltin chlorides with phospholipid bilayers was studied by means of 1H-NMR and differential scanning calorimetry. It is observed that diphenyltin chloride affects the phase transition of DPPC much more than triphenyltin chloride. The aromatic protons of both di- and triphenyltin chlorides give two 1H-NMR signals, which are shifted in the presence of lecithin.
11
Effect of divalent metal ions on annexin-mediated aggregation of asolectin liposomes
58%
Mel'gunov V. I. , Akimova E. I. , Krasavchenko K. S.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 3
EN
Annexins belong to a family of Ca2+- and phospholipid-binding proteins that can mediate the aggregation of granules and vesicles in the presence of Ca2+. We have studied the effects of different divalent metal ions on annexin-mediated aggregation of liposomes using annexins isolated from rabbit liver and large unilamellar vesicles prepared from soybean asolectin II-S. In the course of these studies, we have found that annexin-mediated aggregation of liposomes can be driven by various earth and transition metal ions other than Ca2+. The ability of metal ions to induce annexin-mediated aggregation decreases in the order: Cd2+>Ba2+, Sr2+> Ca2+>>Mn2+>Ni2+>>Co2+. Annexin-mediated aggregation of vesicles is more selective to metal ions than the binding of annexins to membranes. We speculate that not every type of divalent metal ion can induce conformational change sufficient to promote the interaction of annexins either with two opposing membranes or with opposing protein molecules. Relative concentration ratios of metal ions in the intimate environment may be crucial for the functioning of annexins within specialized tissues and after treatment with toxic metal ions.
12
Effects of caffeine on NMDA-evoked 45 Ca2 release in the rat dentate gyrus in vivo
51%
Alaraj M. , Kosinska I. , Lazarewicz J. W.
Acta Neurobiologiae Experimentalis
|
1998
|
tom 58
|
nr 4
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