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Wplyw immunizacji przeciw influenzie koni na parametry odpornosci komorkowej

100%

Zaleska M. , Anusz K. , Kita J.

nr 02

90-93

Six thoroughbred horses formed a study group which was immunized twice with a vaccine (Equigrip, Rhone-Merieux), the control group was six unvaccinated horses. Blood was collected for hematological examinations, cellular immune responses, specific humoral immunity (HI) at days 0, 17, 34, 83, 117 and 123 of the experiment. On day 117 of the experiment, 3 horses of the experimental group and 3 horses of the control group were infected intranasally with a mixture of 2 subtypes (A-l and A-2) of the influenza virus. It is worth noting that 17 days after the first vaccination the lymphocyte stimulation index increased in all horses in the experimental group, while in four of the six unvaccinated horses (control) the index decreased. During this time a statistically significant increase of the specific antibodies titres was not found in vaccinated horses. Six days after the infection, the fairly high level of specific humoral immunity was accompanied by a strong stimulation of cellular immunity, which was expressed as a statistically significant increase in the lymphocyte stimulation index (as determined by the specific blastic transformation test) and was higher in vaccinated horses. Reisolation of the virus, which was attempted five days after the challenge from the nasal cavities of vaccinated horses was unsuccessful, while influenza virus subtype 2 was isolated from each of the vaccinated horses.

Wpływ efektywnych mikroorganizmów na nieswoistą odporność komórkową u sandacza

100%

Terech-Majewska E. , Kaczorek E. , Schulz P. , Zakes Z. , Rozynski M. , Kowalska A. , Zembrzuska M. , Siwicki A. K.

Medycyna Weterynaryjna

2018

tom 74

nr 05

Effective Microorganisms (EM) technology uses microorganisms to work in the surrounding environment. Complex microbiological preparations show synergistic effects, combining the effects of probiotics, prebiotics and synbiotics. EMTM technology is well-known and used in 120 countries worldwide, mainly in agriculture, including aquaculture, and in environmental protection. Fish farmers use these preparations to enhance fish growth, condition and immunity. The aim of the study was to evaluate the effect of EM-Probiotic (Greenland) on the development of cellular non-specific resistance in pikeperch (Sander lucioperca) at the initial stage of rearing in a recirculating aquaculture system (RAS). The experimental diet was administered for 28 days with EM supplementation at 0% (control group), 2% and 4% of the feed. Water temperature in the RAS was maintained at 22.0ºC. Hematopoietic organs (spleen and kidney) were collected twice, after 28 days of EM supplementation (first term) and 28 days after cessation of supplementation (second term). The respiratory burst activity (RBA) and potential killing activity (PKA) of macrophages, as well as the proliferative activity of T- and B-lymphocytes (MTT assay) were assessed. The results of the study show that EM at the initial stage of pikeperch development (body weight of 2 to 14 g) suppress cellular defence mechanisms, decreasing the activity of immunocompetent cells in RBA, PKA and MTT tests. The results from the first organ harvesting showed differentiated EM activity at a statistically insignificant level (P > 0.05). In samples collected 28 days later, the inhibitory effect was demonstrated at a statistically significant level (P < 0.05) in all parameters in both experimental groups. Non-specific cellular immunity in fish plays a key role in defence against damaging factors, including pathogenic ones. Since fish in an RAS are also susceptible to potentially pathogenic agents, immunosuppression of these mechanisms may aggravate the disease.

Wpływ oksytetracykliny stosowanej per os na wybrane parametry odporności komórkowej u indyków

100%

Tykalowski B. , Stenzel T. , Smialek M. , Pestka D. , Choszcz D. , Koncicki A.

Medycyna Weterynaryjna

2013

tom 69

nr 07

The aim of this study was to determine the influence of oxytetracycline given per os at a dose of 0.5 g/L in drinking water for 5 days on selected parameters of the cell-mediated immunity of 5-week-old turkeys. The research was carried out on forty turkeys divided into two groups (20 birds per group). The percentage of CD3+CD4+ and CD3+CD8+ T lymphocytes as well as IgM+ B lymphocytes were determined by flow cytometry in the blood and spleens of turkeys in the control and in the experimental group after 5 days of oxytetracycline administration and 6 days later. The results of this study show that oxytetracycline given per os (0.5 g/L) as outlined above, has no effect on the percentage of the CD3+CD4+ T lymphocyte subpopulation in the blood of turkeys. On the other hand, we were able to determine that it caused a statistically significant decrease in the percentage of CD3+CD8+ T and IgM+ B lymphocyte subpopulations in blood. The results show that six days after the administration of the antibiotic, there was a statistically significant decrease in the percentage of the CD3+CD8+ T lymphocyte subpopulation among the mononuclear cells of the spleen. A significant decrease in the CD3+CD4+ T lymphocyte subpopulation percentage and an increase in the IgM+ B lymphocyte subpopulation percentage in the spleen were recorded both after 5 days of oxytetracycline administration and 6 days later in the experimental groups of turkeys. It can be claimed that oxytetracycline given to turkeys at a dose of 0.5 g/L for five days in drinking water causes the immunosuppression of the cell-mediated mechanisms of their immune system, which can lead to infections by opportunistic pathogens, as well as weakened post-vaccination immunity.