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Correlation of Fine Needle Aspiration Cytology of Thyroid Gland with Histopathological Results

100%

Machała E. , Sopiński J. , Iavorska I. , Kołomecki K.

Polish Journal of Surgery

2018

tom 90(6)

13-19

Fine needle aspiration cytology (FNAC) is considered as the gold-standard diagnostic test in the diagnostics of thyroid nodules. It is a cost-effective procedure that provides specific diagnosis rapidly with minimal complications. It plays an important role in the determination of treatment - patients with suspected malignancy diagnosis can be subjected to surgery. On the other hand, it can decrease the rate of unnecessary surgeries. Aim: The aim of this study was to evaluate and compare the correlation, accuracy of fine needle aspiration cytology (FNAC) in the diagnostics of thyroid lesions with the final histopathologic diagnosis based on the surgical specimens. Materials and Methods: In our study we performed a retrospective analysis of a case series of patients who had been admitted to the Department of Endocrine, General and Oncological Surgery of the Hospital of M. Kopernik in Łodź (Poland) between May 2016 and December 2017 and underwent FNAC with subsequent surgery. Cytological diagnosis was classified into six Bethesda categories. Results: On cytological examination, 1070/1262 cases were reported as benign, 49 as malignant and 143 as suspicious. On histopathological examination, 956/1070 cases were confirmed as benign but there were 114 discordant cases. Among the other cases histopathology diagnosis confirmed malignancy in 45/49 cases and 128/143 suspicious cases. The sensitivity and specificity were 60,28% and 98,05% respectively. False positive rate was 1.95% and false negative rate was 39.72%. The positive predictive value was 90.1% and negative predictive value was 89.35%. Accuracy of FNA in differentiating benign from malignant thyroid lesions was 89.46%.

Occupational daily walking steps have inverse relationship with papillary thyroid cancer risk and progression: a retrospective analysis

86%

Zhang C. , Zhang L. , Su Y. , Xiang L. , Zhang Q. , Zhang C. , Huan Q.

International Journal of Occupational Medicine and Environmental Health

2024

tom 37

nr 1

58-71

Objectives Investigate the impact of daily occupational walking steps on the progression of papillary thyroid cancer (PTC), a topic hitherto underresearched. Material and Methods The authors analyzed the data from 800 individuals with PTC across stages 0–IV. Participants were evenly divided into 2 distinct occupational groups: office workers and construction workers (N = 400 each). Data included comprehensive records of daily walking steps, demographic information, and clinical indicators. Pearson’s correlation coefficients or analysis of variance (ANOVA) were employed to assess the linkage between daily walking steps and PTC risk and stage, as well as associated biochemical markers. Results The analysis revealed a significant inverse relationship between daily walking steps and PTC risk. A higher frequency of daily steps was associated with reduced chances of PTC onset and a lower diagnostic stage of the disease. This protective effect of physical activity was particularly pronounced in the construction worker cohort. Subsequent evaluations showed that construction workers who consistently logged higher daily steps had markedly lower levels of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, thyroid peroxidase antibody, thyroglobulin antibody, and thyroglobulin (Tg). Notably, daily walking steps exhibited a strong inverse correlation with body mass index (BMI), age, PTC volumes, and levels of TSH and Tg across both occupational groups (ρ < –0.37). The increase in daily steps was associated with the reduction in PTC stages (p < 0.001). Conclusions The research underscores the potential benefits of increased daily walking steps, suggesting that they may play a protective role in reducing PTC risk and moderating its progression.

The role of immunohistochemical examination in diagnosis of papillary thyroid cancer in struma ovarii

86%

Szczepanek-Parulska E. , Pioch E. , Cyranska-Chyrek E. , Wolinski K. , Jarmolowska-Jurczyszyn D. , Janicka-Jedynska M. , Majewski P. , Zabel M. , Ruchala M.

Folia Histochemica et Cytobiologica

2019

tom 57

nr 1

Kinase expression and chromosomal rearrangements in papillary thyroid cancer tissues: investigations at the molecular and microscopic levels

58%

Weier H.-U. G. , Kwan J. , Lu C.-M. , Ito Y. , Wang M. , Baumgartner A. , Hayward S. W. , Weier J. F. , Zitzelsberger H. F.

Journal of Physiology and Pharmacology. Supplement

2009

tom 60

nr 4