Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 1996

1 Oku N.

Znaleziono wyników: 1

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: palmityl-D-glucuronide

Sortuj według:

Ogranicz wyniki do:

Basic study on functional liposomes and their application

100%

Oku N.

Cellular and Molecular Biology Letters

1996

tom 01

nr 4

Liposomes have been used as models of biomembranes and tools in the field of drug delivery systems. Liposomalization of various drugs has been revealed to enhance their efficacy and to reduce the side effect of the drugs. For site-specific delivery, intracellular targeting, and controlled release of drugs, many functional liposomes have been developed based on their nature as models of biomembranes. In this paper, preparation and characterization of three kinds of functional liposomes are presented, namely, thermosensitive liposomes for delivering macromolecules, pH-sensitive liposomes for cytosolic delivery of the encapsulated materials, and reticuloendothelial system (RES)-avoiding liposomes for passive targeting to tumor tissues. The actual usefulness of RES-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide, for tumor imaging and therapy was demonstrated. Recently, a method to analyze liposomal trafficking in living animals, which is important in the use of liposomes as drug carriers, was developed by use of positron emission tomography. In this paper, liver accumulation of liposomes having various charges is shown.