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1 Journal of Physiology and Pharmacology

1 2003

1 Goraca A.

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Negative chronotropic effect of endothelin-1 [ET-1] in the cardiac pacemaker tissue

100%

Goraca A.

Journal of Physiology and Pharmacology

2003

tom 54

nr 1

The aim of this study was to asses the direct effect of ET-1 on spontaneous discharge rate of the pacemaker tissue in the presence of isoproterenol. The experiments were performed on pacemaker tissue of the isolated right auricle of the right heart atrium of a two-day-old rat. The spontaneous discharge rate of the pacemaker tissue was recorded on the ECG apparatus and analyzed by the computer. ET-1 alone did not significantly affect the discharge rate of the pacemaker tissue. Isoproterenol rapidly increased the discharge rate of the pacemaker tissue. ET-1 had negative chronotropic effect in the presence of isoproterenol. JKC – 301, a blocker of ETA receptors, significantly reduced the negative chronotropic effect of ET-1 in the presence of isoproterenol, whereas IRL – 1038, a blocker of ETB receptors, did not significantly affect the negative chronotropic effect of ET-1 in the presence of isoproterenol. In conlusion, the negative chronotropic effect of ET-1 in the presence of beta-adrenergic stimulation the pacemaker tissue of the right auricle of the right heart atrium of the two-day-old rat is mediated by ETA receptors.