Wyniki wyszukiwania - Biblioteka Nauki

1

Prostaglandin E1, E2 and oxytocin in labor induction

100%

Dragoljub Plesinac S.

Open Medicine

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2006

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tom 1

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nr 4

416-418

EN

The risks of induction must be carefully weighed against the risks of allowing the pregnancy to continue and not inducing labor. The aim of the study was to show labor and neonatal outcome of 335 deliveries inducted in 2004 at Institute of gynecology and obstetrics Clinical Center of Serbia. Inductions were performed with PGE2, PGE1 and Oxytocin. The best ripening effect was noted in PGE2 group. The average duration of labor was 8.6h in PGE1group, 5.9h in PGE2 group and 10.4h in OT group. Sixty eight labors finished with cesarean section (20%). Comparing duration of labor, percentage of emergency cesarean sections, incidence of fetal distress during the labor we suggest Dinoprostone, placed intracervically, as an agent of choice for induction of labor.

2

The effect of oxytocin [OT] and VIP on the PRL and LH secretion by porcine pituitary cells after treatment with exogenous progesterone

100%

Bogacka I. , Przala J.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

3

TGLP-1 and release of vasopressin and oxytocin from the isolated rat hypothalamo-neurohypophysial system: effects of a TGLP-1 receptor agonist and antagonist

100%

Bojanowska E. , Stempniak B.

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2001

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tom 52

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nr 4,2

EN

To date, glucagon-like peptide–1 (7-36) amide (tGLP-1) has been found to enhance the vasopressin and oxytocin secretion in vivo but not in vitro (i.e., when the isolated neurointermediate lobe of the pituitary was used for experiments). The goal of this study was to investigate whether tGLP-1 can influence the function of the hypothalamo-neurohypophysial complex in vitro. Also, the effect of a tGLP-1 agonist, exendin-4, and antagonist, exendin-(9-39), on the release of vasopressin/oxytocin from the isolated rat hypothalamo-neurohypophysial complex was tested. tGLP-1 enhanced the basal but not the potassium-stimulated release of vasopressin and oxytocin from the hypothalamo-neurohypophysial complex. On the other hand, tGLP-1 failed to affect the release of both hormones from the isolated neurointermediate lobe. The tGLP-1 agonist increased the secretion of oxytocin and vasopressin from the hypothalamo-neurohypophysial system whilst the tGLP-1 antagonist completely abolished the stimulatory effect of tGLP-1 on the secretion of both hormones. It is concluded that tGLP-1 affects the function of vasopressin- and oxytocinergic neurones through specific hypothalamic receptors.

4

Studies on the vasopressin and oxytocin storage in the hypothalamus and neurohypophysis

88%

Guzek J. W.

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tom 38

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nr 6

5

Selected nonapeptides in terahertz light

88%

Fuglewicz B. , Pliński E. F. , Jarząb P. P. , Plińska S. , Cebrat M. , Nowak K. , Augustyn L. , Walczakowski M. J. , Mikulics M. , Pałka N. , Szustakowski M.

Optica Applicata

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2014

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tom Vol. 44, nr 1

159--171

EN

Eight synthetic histidine analogues of oxytocin and vasopressin are subject of investigations. The spectra of the peptides have been investigated in the terahertz band. The results are obtained in the terahertz time-domain spectroscopy arrangement.

6

Regulation of bovine intra-luteal function by peptide hormones

88%

Schams D.

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1992

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tom 43

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nr 1

7

TRANSGENERATIONAL EFFECTS IN LIGHT OF EPIGENETICAL RESEARCH

75%

Varga K.

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tom 66

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nr 3

507-532

EN

Transgenerational effects are well-known in clinical work. The effect of trauma may appear in those persons who themselves had not been directly involved in the original traumatic event, but their ancestors somehow passed it on to them. The modern epigenetic research provides biological explanation concerning the mechanism of transgenerational transmission. This means that different sets of genes can be silenced or activated depending on the epigenetical mechanisms, meanwhile the basic DNA sequence is the same. This way the epigenetical mechanisms allow the organism to react quickly to the environmental change, and these can be transmitted to the next generation if the conditions remain the same. This paper – following the short discussion of these mechanisms – raises some perinatal and psychotherapeutical implications of these phenomena.

8

Thyrotropin-releasing hormone modulates vasopressin and oxytocin synthesis and release from the hypothalamo-neurohypophysial system of different age male rats

75%

Ciosek J. , Izdebska K.

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nr 2

63-70

EN

Thyrotropin-releasing hormone (TRH) is engaged in the modulation of the hypothalamo-neurohypophysial system activity. Effects of repeated intravenously injections of TRH in a dose of 100 ng/100 g b.w. on vasopressin (VP) and oxytocin (OT) biosynthesis and release from the hypothalamo-neurohypophysial system was investigated in rats in different age (1-, 3- or 7-months of the life). To estimate the biosynthesis rate of both neurohormones the colchicine procedure was used (the dose of 5 µg/5 µl icv 20 hours before the decapitation). It has been observed that vasopressin synthesis in the hypothalamus increased gradually with maturation of rats, while OT biosynthesis decreased in the same animals. Hypothalamic biosynthesis rate of VP and OT is most effective in youngest rats and declines during the adolescence of animals. Thyrotropin-releasing hormone directly affects VP-ergic and OT-ergic hypothalamic neurons activity and both neurohormones biosynthesis process. This effect, however, is opposed: TRH acts as a stimulator of vasopressin biosynthesis most of all in young male rats and as an inhibitor for oxytocin biosynthesis especially in mature animals.

9

Nesfatin-1 protects from acute pancreatitis: role of melanocortin receptors

75%

Buzcu H. , Ozbeyli D. , Yuksel M. , Cilingier Kaya O. T. , Kasimay Cakir O.

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tom 70

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nr 6

10

Counter current transfer of oxytocin in vasculature of cows broad ligament

75%

Koziorowski M. , Stefanczyk-Krzymowska S. , Czarnocki J. , Krzymowski T.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1989

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tom 37

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nr 4-6

11

Effect of polychlorinated biphenyls (PCBs) on basal and OT-stimulated calcium concentrations in myometrial cells in cows

75%

Wrobel M. , Kotwica J.

Reproductive Biology

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2005

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tom 05

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nr 3

12

Effect of a prostacyclin analogue on the vasopressin and oxytocin secretion in vitro

75%

Bojanowska E. , Guzek J. W.

Acta Physiologica Polonica

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1990

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tom 41

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nr 7

EN

Bojanowska E. and Guzek J. W.: Iloprost (ZK 36374; a stable prostacyclin analogue) increases basal as well as potassium-evoked vasopressin and oxytocin secretion from rat neurointermediate lobes in vitro. This finding suggests a possible regulatory role of endogenous prostacyclin in the release of neurohypophysial hormones.

13

Impact of the length of exposure to peptides of different molecular mass on the establishment of imprinting in Tetrahymena

75%

Kohidai L. , Csaba G.

Acta Protozoologica

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1990

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tom 29

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nr 4

14

Effect of oxytocin and its analogues on the chemotaxis of Tetrahymena: evolutionary conclusions

75%

Csaba G. , Kovacs K. , Kohidai L.

Acta Protozoologica

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2000

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tom 39

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nr 4

15

The influences of GnRH, oxytocin and vasoactive intestinal peptide on LH and PRL secretion by porcine pituitary cells in vitro

75%

Bogacka I. , Siawrys G. , Okrasa S. , Kaminski T. , Przala J.

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nr 3

EN

The aim of the present study was to evaluate the possible direct effects of GnRH, oxytocin (OT) and vasoactive intestinal peptide (VIP) on the release of LH and PRL by dispersed porcine anterior pituitary cells. Pituitary glands were obtained from mature gilts, which were ovariektomized (OVX) one month before slaughter. Gilts randomly assigned to one of the four groups were treated: in Group 1 (n=8) with 1 ml/100 kg b.w. corn oil (placebo); in Group 2 (n=8) and Group 3 (n=8) with estradiol benzoate (EB) at the dose 2.5 mg/100 kg b.w., respectively, 30-36 h and 60-66 h before slaughter; and in Group 4 (n=9) with progesterone (P4) at the dose 120 mg/100 kg b.w. for five consecutive days before slaughter. In gilts of Group 2 and Group 3 treatments with EB have induced the negative and positive feedback in LH secretion, respectively. Isolated anterior pituitary cells (106/well) were cultured in McCoy's 5a medium with horse serum and fetal calf serum for 3 days at 37°C under the atmosphere of 95% air and 5% CO2. Subsequently, the culture plates were rinsed with fresh McCoy's 5A medium and the cells were incubated for 3.5 h at 37°C in the same medium containing one of the following agents: GnRH (100 ng/ml), OT (10-1000 nM) or VIP (1-100 nM). The addition of GnRH to cultured pituitary cells resulted in marked increases in LH release (p<0.001) in all experimental groups. In the presence of OT and VIP we noted significant increases (p<0.001) in LH secretion by pituitary cells derived from gilts representing the positive feedback phase (Group 3). In contrast, OT and VIP were without any effect on LH release in Group 1 (placebo) and Group 2 (the negative feedback). Pituitary cells obtained from OVX gilts primed with P4 produced significantly higher amounts (p<0.001) of LH only after an addition of 100 nM OT. Neuropeptide GnRH did not affect PRL secretion by pituitary cells obtained from gilts of all experimental groups. Oxytocin also failed to alter PRL secretion in Group 1 and Group 2. However, pituitary cells from animals primed with EB 60-66 h before slaughter and P4 produced markedly increased amounts of PRL in the presence of OT. Neuropeptide VIP stimulated PRL release from pituitary cells of OVX gilts primed with EB (Groups 2 and 3) or P4. In contrast, in OVX gilts primed with placebo, VIP was without any effect on PRL secretion. In conclusion, the results of our in vitro studies confirmed the stimulatory effect of GnRH on LH secretion by porcine pituitary cells and also suggest a participation of OT and VIP in modulation of LH and PRL secretion at the pituitary level in a way dependent on hormonal status of animals.

16

Vasopressin and oxytocin release and the thyroid function

75%

Ciosek J. , Drobnik J.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 2

EN

The aim of the present investigations was to examine the effects of the states of hypothyroidism or hyperthyroidism on vasopressin (AVP) and oxytocin (OT) release under conditions of equilibrated water metabolism as well as of osmotic stimulation, brought about by the dehydration or hypertonic saline administration. The euhydrated and simultaneously hypothyroid rats showed decreased hypothalamic AVP and OT content and somewhat higher but not significant neurohypophysial AVP content. In these animals the raised OT (but not AVP) plasma level has been observed. In hyperthyroid rats drinking tap water ad libitum the neurohypophysial AVP and OT content significantly diminished; plasma OT concentration (but not AVP) was then elevated. The state of osmotic stimulation was the reason of different response of the hypothalamo-neurohypohysial system function in hypo- or hyperthyroid rats. Significant decreases of neurohypophysial AVP and OT content were found in both hypothyroid dehydrated as well as hypothyroid hypertonic saline-treatment rats as compared with hypothyroid euhydrated ones. On the contrary, in the state of hyperthyroidism AVP content in the neurohypophysis distinctly raised in dehydrated and salt-loaded rats; in these last neurohypophysial OT content increased as well. Plasma OT (but not AVP) distinctly diminished in hyperthyroid and simultaneously dehydrated or hypertonic saline injected rats in relation to hyperthyroid control subgroup. Data from the present study suggest that: 1) altered thyroid gland function affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in the state of equilibrated water metabolism; 2) the state of hypo- or hyperthyroidism modifies the response of AVP-ergic and OT-ergic neurons upon the osmoreceptors/osmodetectors stimulation. It may be sypposed that OT-ergic neurons display greater than AVP-ergic neurons sensitivity upon the thyroid hormone influence.

17

Vasopressin release from posterior pituitary lobe incubated in situ after preganglionic stimulation of the rat superior cervical ganglion

75%

Lipinska S. , Orlowska-Majdak M. , Traczyk W. Z.

Journal of Physiology and Pharmacology

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1992

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tom 43

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nr 4

EN

In uretane-chloralose anaesthesia the pituitary gland was exposed by transpharyngeal approach in rats. The anterior lobe was removed and the posterior lobe was incubated in situ, that is in conditions of anatomical integrity of the hypothalamus with the posterior pituitary lobe. The 15-min samples of the medium incubating the posterior pituitary lobe in situ were collected. Vasopressin (AVP) content in the incubation medium was determined by radioimmunoassay. The stimulation of preganglionic fibers of the superior cervical ganglion (SCG) with alternate short (5 s) bursts of electric pulses with short (5 s) breaks did not change A VP release. However, stimulation of preganglionic fibres with alternate long (30 s) bursts of electric pulses with long (30 s) breaks evoked an increase in AVP release after some latency . Probably, at the hypothalamic or posterior pituitary level temporal summation should occur affecting vasopressinergic neurons or their endings and evoking AVP release.

18

Neurokinin A and the neurohypophysial response to malatonin: in vitro studies

75%

Juszczak M.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 4,2

EN

The aim of this study was to investigate a possible role of neurokinin A (a member of a family of peptides known as tachykinins) in the pineal-neurohypophysial interrelationship. The effect of neurokinin A (NKA) alone or in the presence of pineal hormone - melatonin on basal and K + -stimulated vasopressin and oxytocin secretion from the hypothalamo-neurohypophysial system was studied in vitro. The present results show that NKA stimulated basal vasopressin and oxytocin release from the isolated hypothalamo-neurohypophysial system, when used at the concentration of 10-7 M/L. Melatonin diminished basal release of the neurohypophysial hormones; it also significantly inhibited the NKA-stimulated secretion of vasopressin and oxytocin. Lower concentrations of NKA did not affect the neurohypophysial hormones basal release, however, when melatonin was added to the medium enriched with NKA at the concentration of 10-9 M/L, the vasopressin secretion from the hypothalamo-neurohypophysial explants was decreased significantly. The K+ -evoked release of neurohypophysial hormones was not further modified by either NKA or melatonin. The present results confirm previous reports as to the inhibitory effect of melatonin on both vasopressin and oxytocin secretion from the hypothalamo-neurohypophysial complex in vitro. However, under present experimental conditions, the contribution of NKA in the mechanisms of pineal- neurohypophysial interrelationships has not been demonstrated.

19

Thyrotropin-releasing hormone [TRH] modulates vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in dehydrated rats

75%

Ciosek J. , Guzek J. W. , Orlowska-Majdak M.

|

nr 3

20

Czy za miłością kryje się chemia?

63%

Gargula K. , Głąb M.

Analit

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2023

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tom Nr 13

12--17

PL

Miłość jest skomplikowanym zjawiskiem, które ciężko opisać uwzględniając tylko jedną perspektywę. Do jego opisania konieczne jest zarówno skorzystanie z pomocy nauki, jak i podejście do problemu od strony społeczno-psychologicznej. Korzystając z wiedzy nabytej dzięki odwiecznemu poszukiwaniu rozwiązania zagadki jaką jest ciało człowieka, możemy zauważyć, że koncepcja miłości jest zwykle powiązywana z konkretnymi, występującymi w organizmie hormonami oraz neuroprzekaźnikami, takimi jak oksytocyna, wazopresyna, dopamina, serotonina, noradrenalina, endorfiny oraz hormony płciowe. Substancje te odpowiadają za regulację naszych stanów emocjonalnych, a także powstawanie więzi. Z jednej strony, bez hormonalnych bodźców niemożliwe byłoby wywołanie odczuć jakie kojarzone są z miłością, a z drugiej bez społeczno-psychologicznych czynników nie wiedzielibyśmy czym naprawdę jest miłość. Zjawisko to ma wiele przypadków, które nie wpisują się w czysto naukowy schemat i mogłyby być wyjaśnione jedynie przy użyciu reakcji chemicznych. Często pojawieniu się tego uczucia towarzyszy konkretna sytuacja w jakiej znajduje się dana osoba. Na miłość ma wpływ zarówno unikalny dla jednostki stan psychiczny, jak i otoczenie, w którym funkcjonuje.

EN

Love is a complex phenomenon that is hard to describe considering only one perspective. To describe it, it is necessary both to take the help of science and to approach the problem from the socio-psychological side. Using the knowledge acquired through the eternal search for a solution to the riddle that is the human body, we can see that the concept of love is usually associated with specific hormones and neurotransmitters found in the body, such as oxytocin, vasopressin, dopamine, serotonin, norepinephrine, endorphins, and sex hormones. These substances are responsible for regulating our emotional states, as well as the formation of bonds. On the one hand, without hormonal stimuli it would be impossible to produce the feelings that are associated with love, and on the other hand, without socio-psychological factors we would not know what love really is. This phenomenon has many cases that do not fit into a purely scientific scheme and could only be explained using chemical reactions. Often the appearance of feeling is accompanied by the specific situation in which the person finds themself. Love is influenced by both the psychological state unique to the individual and the environment in which he functions.