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Sister chromatid exchanges induced in vitro in human lymphocytes by N-substituted phosphorodiamidic acids

100%

Ciesielska E. , Mordalska A. , Dzwonkowska A. , Kinas R. , Szmigiero L.

Acta Biochimica Polonica

1993

tom 40

nr 1

In vitro activity of axazaphosphorines in childhood acute leukemia: preliminary report

100%

Styczynski J. , Wysocki M. , Debski R. , Balwierz W. , Rokicka-Milewska R. , Matysiak M. , Balcerska A. , Kowalczyk J. , Wachowiak J. , Sonta-Jakimczyk D. , Chybicka A.

Acta Biochimica Polonica

2002

tom 49

nr 1

Glufosfamide (β-D-glucosyHfosfamide mustard) is a new agent for cancer chemotherapy. Its pharmacology is similar to commonly used oxazaphosphorines, but it does not require activation by hepatic cytochrome P-450 and preclinically demonstrates lower nephrotoxicity and myelosuppression than ifosfamide. The aim of the study was a comparison of the drug resistance profiles of glufosfamide and other oxazaphosphorines in childhood acute leukemias. Leukemic cells, taken from children with ALL on diagnosis (n = 41), ALL on relapse (n = 12) and AML on diagnosis (n = 13) were analyzed by means of the MTT assay. The following drugs were tested: glufosfamide (GLU), 4-HOO-ifosfamide (IFO), 4-HOO-cyclophosphamide (CYC) and mafosfamide cyclohexylamine salt (MAF). In the group of initial ALL samples median cytotoxicity values for GLU, IFO, CYC and MAF were 15.5, 33.8, 15.7 and 7.8,«M, respectively. In comparison with initial ALL samples, the relative resistance for GLU and IFO in relapsed ALL samples was 1.9 (p = 0.049) and 1.3 (ns), and in initial AML samples 31 (p < 0.001) and 5 (p = 0.001), respectively. All oxazaphosphorines presented highly significant cross-resistance. Glufosfamide presented high activity against lymphoblasts both on diagnosis and on relapse.

Comparative effects of new generation oxazaphosphorines on the size and viability of human acute myeloblastic leukemia cells

84%

Mazur L. , Opydo-Chanek M. , Wojcieszek K. , Stojak M. , Niemeyer U.

Folia Biologica

2012

tom 60

nr 1-2

Mitotic catastrophe induction in U937 cells by oxazaphosphorines

84%

Mazur L. , Stojak M. , Opydo-Chanek M. , Niemeyer U.

Acta Biologica Cracoviensia. Series Zoologia

2009

tom 51

17-22

Induction of DNA breakage in U937 cells by oxazaphosphorines

84%

Mazur L. , Opydo-Chanek M. , Stojak M. , Baran J. , Niemeyer U.

Folia Biologica

2010

tom 58

nr 1-2

15-20

Frequency of micronuclei induced in the mouse erythropoietic system by new generation oxazaphosphorines

84%

Mazur L. , Opydo-Chanek M. , Niemeyer U.

Acta Biologica Cracoviensia. Series Zoologia

2008

tom 50

Aldehyde dehydrogenase isoenzymes in tumours - assay with possible prognostic value for oxazaphosphorine chemotherapy

84%

Wroczynski P. , Laskowska A. , Wierzchowski J. , Szubert A. , Polanski J. , Slowiaczek M.

Acta Biochimica Polonica

1998

tom 45

nr 1

A novel fluorimetric assay, allowing independent measurement of the activities of two principal cytosolic forms of human aldehyde dehydrogenase, ALDH-1 and ALDH-3 (known as a tumour-associated ALDH) was applied to estimate the activities of these isoenzymes in human liver and thyroid tumours. The assay is based on two artificial substrates, 6-methoxy-2-naphthaldehyde (MONAL-62) and 7-methoxy-1-naphthaldehyde (MONAL-71), exhibiting excellent substrate properties toward various forms of human ALDH (see Wierzchowski et al., 1997, Anal. Biochem. 245, 69-78). We have found significant differences in ALDH activities between malignant and non-malignant tissue fragments, particularly in cancerous livers. Out of 16 tumours examined, only 4 exhibited ALDH-1 activities comparable to that found in the tumour-free tissue (0.5-2.5 U/g), while in the remaining 12 this activity was at least 10-fold lower. The ALDH-3 activity was detectable in about 40% of both tumour and tumour-free liver samples (maximum value 1.5 U/g). Comparison of 13 pathological thyroid fragments revealed ALDH activities in the range of 0.02 to 0.35 U/g, with two malignant samples showing activities of 0.27 and 0.18 U/g. Both substrate specificity and kinetic behaviour of the thyroid ALDH (Km values for the fluorogenic naphthaldehydes as well as propanal inhibition profile) were similar to those of the purified ALDH-1. In 5 thyroid samples traces of ALDH-3 activity was detected, using MONAL-62 and NADP+ as substrates (maximum value 0.04 U/g). Possible prognostic value of the foregoing measurements for cyclophosphamide chemotherapy is discussed.

In vitro effects of new generation oxazaphosphorines on human promyelocytic leukemia cells

67%

Mazur L. , Opydo-Chanek M. , Stojak M. , Niemeyer U.

Folia Biologica

2013

tom 61

nr 1-2