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A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning

100%

Lovrić J. , Berend S. , Lucić Vrdoljak A. , Radić B. , Katalinić M. , Kovarik Z. , Želježić D. , Kopjar N. , Rast S. , Mesić M.

Acta Biochimica Polonica

2011

tom 58

nr 2

193-198

A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. Its genotoxic profile was assessed on human lymphocytes in vitro and was found acceptable for further research. ATR-4-OX showed very weak antidotal activity, inadequate for soman or tabun poisoning. Conversely, it was effective against paraoxon poisoning both in vitro and in vivo. All animals treated with 5 % or 25 % LD50 doses of the new oxime survived after administration of 10.0 or 16.0 LD50 doses of paraoxon, respectively. Based on the persistence of toxicity symptoms in mice, the atropine moiety had questionable effects in attenuating such symptoms. It appears that ATR-4-OX has a therapeutic effect related to the reactivation of phosphylated AChE, but not to receptor antagonization.

Neurological effects of acute exposure to caffeine and organophosphates in mice

86%

Łukawski K. , Raszewski G. , Kruszyński K. , Czuczwar S. J. , Łukawski K. , Raszewski G. , Kruszyński K. , Czuczwar S. J.

nr 2

Harmonizing Biomarker Measurements in Longitudinal Studies of Children’s Health and the Environment

72%

Etzel R. , Charles M.-A. , Dellarco M. , Gajeski K. , Jöckel K.-H. , Hirschfeld S. , Kamijima M. , Kawamoto T. , Kolossa-Gehring M. , Nakayama S. , Schmidt B. , Tian Y. , Wolz B. , Zaros C. , Zhang J.

Biomonitoring

2014

tom 1

nr 1

Large scale studies of environmental influences on children’s health and development are being planned or conducted in many places, including Japan, France, Shanghai (China), the United States, and Germany. The objective of these “next generation” studies is to better understand a broad range of environmental and social factors that influence the health and well-being of children. Some of these studies are designed to enroll tens of thousands of children and follow them for many years to investigate the influence of the environment on child growth, development and health. Environment is broadly defined in these studies and includes investigation of chemical, biological, physical and socioeconomic factors. An international group composed of study teams from Japan, France, Shanghai (China), the United States, and Germany has been meeting since 2011 to exchange information and work towards harmonization of processes that would provide the opportunity to compare methods and develop procedures to conduct combined analyses of results and data pooling procedures. Harmonization of infant health outcomes, biomarkers, environmental measurements, socioeconomic and migration status has been initiated. This manuscript provides an overview of the Environment and Child Health International Birth Cohort Group and its history, describes the progress of work, and discusses the advantages of this international collaborative effort.

Detektor fotojonizacyjny (PID) - zasada działania i przykłady zastosowania

44%

Curyło J. , Wardencki W.

Analityka : nauka i praktyka

2003

tom nr 3

43--46

Detektor fotojonizacyjny (PID) używany jest najczęściej do oznaczania związków aromatycznych będących typowymi zanieczyszczeniami środowiska : alkenów, związków fosforo-organicznych, jak również substancji nieorganicznych takich jak arsenowodór czy amoniak.