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A simple HPLC method for the determination of butorphanol tartrate and ondansetron hydrochloride in patient-controlled analgesia solution

100%

Fang B. , Wang L. , Chen F. , Li P. , Shi X.

tom Vol. 30, no. 1

43--46

A simple and rapid high-performance liquid chromatographic (HPLC) method was established for simultaneous determination of butorphanol tartrate and ondansetron hydrochloride in analgesic mixture samples used for patient-controlled analgesia (PCA). The separation of butorphanol tartrate and ondansetron hydrochloride in PCA solution was carried out on phenomenex C18 column (4.6 mm × 150 mm, 5 μm) using 50 mM sodium acetate (pH 4.0) buffer and acetonitrile (72:28, v/v). Flow rate was 1.0 mL min−1 with a column temperature of 30 °C, and detection wavelength was carried out at 280 nm and 306 nm. Validation of the method was made in terms of specificity, linearity, accuracy, and intra- and inter-day precision, as well as quantification and detection limits. The developed method was successfully used to evaluate the chemical stability of butorphanol tartrate and ondansetron hydrochloride in analgesic mixtures at the usual concentration used for PCA.

Involvement of some 5-HT receptors in methamphetamine-induced locomotor activity in mice

84%

Ginawi O. T. , Al-Majed A. A. , Al-Suwailem A. K. , El-Hadiyah T. M. H.

nr 2

Effects of some selective 5-HT antagonists on methamphetamine-induced locomotor activity were investigated in male mice in order to study whether this effect of methamphetamine is selectively or at least partially, induced through stimulation of a specific serotonin receptor subtype. Methamphetamine (1.5mg/kg, IP) produced a significant increase in locomotor activity. Methamphetamine-induced hyperactivity by the above mentioned dose was signficantly antagonized by NAN-190 ( 5-HT1A antagonist) at a dose of 4 mg/kg, IP, methiothepin (5-HT1B/1D antagonist) at a dose of 0.1mg/kg, IP or mianserin ( 5-HT2C antagonist) at a dose of 8mg/kg, IP. On the other hand, methysergide ( 5-HT 2A/2B antagonist) at a dose of 1mg/kg, IP or ondansetron ( 5-HT3 antagonist) at a dose of 0.5mg/kg, IP potentiated the methamphetamine-induced hyperactivity. None of the above mentioned doses of 5-HT antagonists altered the spontaneous activity of mice when administered alone. The results of the present study indicate a possible role for serotonergic mechanisms, in addition to the catecholaminergic systems, in the locomotor stimulant activity of methamphetamine in mice. This role is possibly mediated through direct stimulation of some 5-HT receptor subtypes. Stimulation by methamphetamine of 5-HT 1A, 5-HT 1B/1D and/or 5-HT2C receptor subtypes may result in hyperactivity, whereas stimulation by methamphetamine of 5-HT 2A/2B and/or 5-HT3 receptor subtypes may result in decreased activity.

Participation of different 5-HT receptors in the memory process in rats and its modulation by the serotonin depletor p-chlorophenylalanine

67%

Petkov V. D. , Belcheva S. , Konstantinova E. , Kehayov R.

tom 55

nr 4