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Syntetyczne oligodeoksynukleotydy zawierajace niemetylowane dinukleotydy cytozyno-guaninowe jako immunostymulatory u drobiu

100%

Szczubelek P. , Szeleszczuk P.

Medycyna Weterynaryjna

2009

tom 65

nr 12

823-826

Fragments of bacterial and viral DNA are identified by the immune system of vertebrates which cause the activation of specific and non-specific mechanisms of immunological response. Similar immunostimulating effects can be achieved by using oligodeoxynucleotides (ODN) consisting of unmethylated cytosine-guanosine dinucleotides (CpG ODN). Numerous studies show the capability of their appliance in treating bacterial, viral and parasitic infections, as well as in the therapy of tumors and cancers and in specific immunoprophylactics of many kinds of animal (including bird) diseases. This fact creates the capability of using CpG ODN in large scale poultry production. The authors describe the influence of CpG ODN on immune system cells and the possibilities of the practical application of CpG ODN in therapy and immunoprophylaxis of poultry diseases.

Nowe tendencje w konstrukcji szczepionek podjednostkowych

84%

Wyszynska A. , Jagusztyn-Krynicka E. K.

Postępy Mikrobiologii

2006

tom 45

nr 2

119-134

Charakterystyka oligodeoksynukleotydow zawierajacych motywy CpG, ich wplyw na komorki ukladu odpornosciowego oraz mozliwosci wykorzystania w medycynie i weterynarii

67%

Chrzastek K. , Wieliczko A.

Medycyna Weterynaryjna

2010

tom 66

nr 04

242-245

DNA Bacterial genomes contain many more unmethylated CpG (cytosine-phosphodiester-guanine) dinucleotides than those of vertebrates. This difference in the genome structure allows the innate immune system of vertebrates to distinguish bacterial DNA from self-DNA. Synthetic oligodeoxynucleotides that contain CpG motifs (CpG ODNs) can mimic bacterial DNA and consequently induce various types and levels of immune responses. Synthetic ODNs CpG stimulates the innate immune system, activates non-specific anti-microbial defense systems, and sensitizes antigen-presenting cells to mount both antibody and cell- -mediated immunity against specific antigens. A better understanding of CpG recognition at the molecular level is fundamental to subsequent immunological response which would allow the optimization and application of CpG motifs as therapeutic agents and adjuvants for numerous diseases. It is to be hoped that CpG ODN treatment of animals could also provide a cost-effective alternative to antibiotics by increasing resistance to disease-causative pathogens.