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1
Effect of lectin from Chelidonium majus L. on normal and cancer cells in culture
100%
Fik E. , Wolun-Cholewa M. , Kistowska M. , Warchol J. B. , Gozdzicka-Jozefiak A.
Folia Histochemica et Cytobiologica
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2001
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tom 39
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nr 2
2
The genotoxicity of amsacrine in normal cells and cancer cells
100%
Blasiak J. , Gloc E.
Cellular and Molecular Biology Letters
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2002
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tom 07
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nr Suppl.
3
DNA damage and repair in normal and neoplastic cells treated with adriamycin
100%
Anuszewska E. L. , Gruber B.
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nr 4
XX
Adriamycin (ADR), a common antineoplastic drug, was used to study DNA repair synthesis, cell cytotoxicity and DNA single strand breaks in normal human fibroblasts — CLV98 and human melanoma cells — ME18. No repair synthesis was observed in ME18 and CLV98 cells exposed to adriamycin in concentrations up to 10~5 M. ME18 cells were less sensitive to ADR treatment than CLV98 cells. Adriamycin-induced DNA single strand breaks (at ADR concentration: 1 pg/ml) were incompletely repaired in ME18 cells and unrepaired in CLV98 cells within 24 h after drug removal. Within 48 h strand breaks were completely repaired in both kinds of cells. No repair of single strand breaks was observed in ME18 and CLV98 cells after drug treatment in the concentration of 5 Jig/ml.
4
pVAX1 plasmid vector-mediated gene transfer of soluble TRAIL suppresses human hepatocellular carcinoma growth in nude mice
84%
Zhang Y. , Ma C. H. , Liu H. , Zhang X. M. , Sun W. S.
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nr 2
EN
The extracellular domain of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may function as a soluble cytokine to selectively kill various cancer cells without toxicity to most normal cells. We used a high-biosafety plasmid pVAX1 as a vector and constructed a recombinant plasmid expressing the extracellular domain (95-281 aa) of human TRAIL fused with signal peptides of human IgGγ, designated as pVAX-sT. Transduction of human BEL7402 liver cancer cells with pVAX-sT led to high levels of sTRAIL protein in the cell culture media and induced apoptosis. The therapeutic potential of pVAX-sT was then evaluated in the BEL7402 transplanted naked mouse model. Subsequent intratumoral administration of naked pVAX-sT resulted in the expression of soluble TRAIL in the sera and the tumor site, as well as effective suppression of tumor growth, with no toxicity to liver. In conclusion, the successful inhibition of liver cancer growth and the absence of detectable toxicity suggest that pVAX-sT could be useful in the gene therapy of liver cancer.
5
Histone mRNA in situ hybridization in assessing proliferative activity of normal and malignant cells
84%
Slowinski J. , Mazurek U. , Bierzynska-Macyszyn G.
Folia Histochemica et Cytobiologica
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2002
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tom 40
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nr 4
6
Estrogen synthesis and DNA content in epidermal growth factor treated stromal cell cultures of human proliferative endometrium
84%
Tomaszewski J. , Semczuk A. , Kotarski J. , Jakowicki J. A.
Folia Histochemica et Cytobiologica. Supplement
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1997
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tom 35
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nr 2
7
Mechanisms of type I interferon signalling in normal and malignant cells
84%
Li Y. , Srivastava K. K. , Platanias L. C.
Archivum Immunologiae et Therapiae Experimentalis
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2004
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tom 52
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nr 3
8
Oligosaccharide structures of N-cadherin from human normal and cancer bladder cell lines by matrix-assisted laser desorption mass spectrometry
67%
Hoja-Lukowicz D. , Litynska A. , Amoresano A. , Ciolczyk-Wierzbicka D. , Laidler P.
Acta Biologica Cracoviensia. Series Zoologia
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2007
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tom 49
31-39
9
Correlation of Ki-67 and MCM-2 proliferative marker expression with grade of histological malignancy (G) in ductal breast cancers
67%
Wojnar A. , Kobierzycki C. , Krolicka A. , Pula B. , Podhorska-Okolow M. , Dziegiel P.
Folia Histochemica et Cytobiologica
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2010
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tom 48
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nr 3
10
Distribution of beta-enolase in normal and tumor rat cells
67%
Seweryn E. , Bednarz-Misa I. S. , Danielewicz R. , Saczko J. , Kulbacka J. , Dawiskiba T. , Pietkiewicz J.
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tom 46
|
nr 4
519-524
11
Content available remote High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-[pyrrolidin-1-YL]ethyl]-aminno-17-demethoxygeldanamycin
67%
Lukasiewicz E. , Miekus K. , Kijowski J. , Gozdzik J. , Wilusz M. , Bobis-Wozowicz S. , Wiecha O. , Majka M.
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nr 3
161-166
EN
Rhabdomyosarcoma is a highly metastatic tumor, mostly observed in children and adolescence. When diagnosed at early stages it is mostly curable. However, in advanced or metastatic stages the 5-years survival rate is below 20%. Thus, new treatment strategies for this tumor are needed. In this paper we showed that HSP90 inhibitors, geldanamycin and its analogs, can profoundly affect proliferation of rhabdomyosarcoma cells. We also showed that blocking of HSP90 function induces apoptosis of tumor cells and downregulates expression of anti apoptotic protein AKT. Cells exposed to geldanamycin and its analogs exhibit strong reduction of MET receptor expression and subsequent inhibition of HGF-dependent tumor cells migration and invasion. Interestingly, at concentrations sufficient to block tumor cells growth and motility, the 17AEP-GA, 17AAG and 17DMAP-GA were not toxic or only slightly toxic toward normal hematopoietic, mesenchymal and endothelial cells. This could be due to low HSP90 expression both at mRNA and protein level in these cells. Collectively, our findings suggest that blocking HSP90 action through geldanmycins could be in the future a part of new therapeutic strategies in rhabdomyosarcoma treatment.
12
The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells
67%
Juszczak M. , Matysiak J. , Niewiadomy A. , Rzeski W.
Folia Histochemica et Cytobiologica
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2011
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tom 49
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nr 3
13
Cellular aspects of folate and antifolate membrane transport
67%
Brzezinska A. , Winska P. , Balinska M.
Acta Biochimica Polonica
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2000
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tom 47
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nr 3
EN
Folates one carbon carriers take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
14
Differential effects of CD40 stimulation on normal and neoplastic cell growth
67%
Ziebold J. L. , Hixon J. , Boyd A. , Murphy W. J.
Archivum Immunologiae et Therapiae Experimentalis
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2000
|
tom 48
|
nr 4
15
The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells
67%
Jakubowicz-Gil J. , Paduch R. , Gawron A. , Kandefer-Szerszen M.
Folia Histochemica et Cytobiologica
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2002
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tom 40
|
nr 1
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