Wyniki wyszukiwania - Biblioteka Nauki

1

Dissipation function and the extravascular influx of circulating noradrenaline during its thermogenic control

100%

Mejsnar J.

Acta Physiologica Polonica

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1990

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tom 41

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nr 7

2

Impact of special aviation gymnastics instruments training on selected hormones in cadets' blood serum and plasma

75%

Wochyński Z. , Sobiech K.

International Journal of Occupational Medicine and Environmental Health

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2017

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tom 30

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nr 4

655-664

EN

Objectives This study has aimed at investigating the impact of the Special Aviation Gymnastics Instruments (SAGI) training scheme on the blood serum cortisol, testosterone, insulin, and plasma adrenaline, noradrenaline, and dopamine in comparison with a control group. Material and Methods Fifty-five cadets, aged 20 years old, participated in the study. Cadets were divided into 2 groups: A (N = 41) – the SAGI-trained, and B (N = 14) – the control group. In both groups, blood was the examined material, sampled twice: before the training session (BT) and after the training session (AT), at the beginning (training session I), during (training session II), and after completion of the SAGI training session (training session III). Commercially available kits were used for assaying serum cortisol, testosterone, and insulin as well as plasma adrenaline, noradrenaline, and dopamine. Cadets’ physical fitness was assessed by means of Aero-Synthetic Efficiency Tests. Results In group A, a significant decrease in serum cortisol (training session III) and insulin in three training sessions AT in comparison with the values BT was seen. A statistically significant increase in testosterone and catecholamines was noted in all 3 training sessions AT in comparison with the values BT. In group B, a statistically significant increase in cortisol (training session II), testosterone, and catecholamines was observed in all 3 training sessions AT vs. the values in training session BT. In group B, serum levels of all assayed hormones were higher in training session III than those in group A. Conclusions In the examined group, the SAGI training produced fewer hormonal changes dependent on the intensity and exercise type and physical efficiency improvement than in the control group. Int J Occup Med Environ Health 2017;30(4):655–664

3

Current concepts in clinical and laboratory assessments of autonomic nervous system activity

75%

Dobrek L. , Thor P.

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tom 09

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nr 1

EN

Introduction and objective. As the autonomic nervous system (ANS) dysfunction is present in course of many disorders, an objective assessment of the ANS function is very important. In practice, the assessment is difficult, and based rather on indirect analysis of autonomically-controlled cardiovascular reflexes, than on direct recording of activity of central or peripheral autonomic structures. The aim of our paper was to discuss briefly current, clinical and scientific ANS investigations, as well as possible future methods of autonomic activity evaluation. A brief description of the state of knowledge. The review presents a short outline of autonomic function assessments based on clinical autonomic tests (e.g. “Ewing’s battery”) and discusses the heart rate variability (HRV) study, as currently popular and widespread option of analysis of the ANS activity. Other, complementary methods, including the baroreceptor sensitivity testing, microneurography or plasma norepinephrine measurement were also mentioned. The article also provides premises related to the determination of selected neuropeptides in plasma or saliva as an innovative concept of autonomic activity assessment. Summary. The available, clinical, non-invasive methods used for assessment of the ANS function are still relatively sparse and, in fact, a surrogate for direct ANS assessment. New methods of autonomic tension determination are still needed that would allow a more complete and reliable assessment. Reports of potential new laboratory markers of the ANS activity (NPY and VIP assay) bring some hope.

4

Aminergic control of vasopressin secretion in the conscious rat

75%

Wells T. , Forsling M. L.

Journal of Physiology and Pharmacology

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1992

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tom 43

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nr 1

EN

The influence of aminergic pathways on basal and stimulated vasopressin (AVP) release was studied in conscious rats, the stimulus for hormone release being an intracerebroventricular (ICV) injection of 5 µl 0.85M sodium chloride. The animals were treated with either phenoxybenzamine, propranolol or haloperidol prior to administration of the central hypertonic stimulus. Phenoxybenzamine elevated basal plasma vasopressin concentrations, while propranolol and haloperidol had no effect. The secretion of АVР in response to the hypertonic stimulus was potentiated by phenoxybenzamine and haloperidol, but the effect of propranolol was equivocal. The antagonists had no effect on basal arterial pressure at the time of hypertonic saline administration or the pressor response to ICV sodium chloride.

5

Effects of infusion of corticotropin-releasing factor antagonist into the locus coeruleus on freezing behavior and brain catecholamines in rats

75%

Swiergiel A. H.

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nr 1

6

Role of the noradrenergic system in the secretory function of the corpus luteum

75%

Kotwica J.

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1992

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tom 43

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nr 1

7

Modulation of sympathoadrenergic contractions by perivascular adipose tissue in mesenteric arteries of rats with different level of body adiposity

63%

Zemancikova A. , Torok J. , Balis P. , Valovic P. , Ulicna O. , Chomova M.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 4

8

Stosowanie wenlafaksyny w dawkach podzielonych – opis kazuistyczny

63%

Święcicki Ł.

Psychiatria i Psychologia Kliniczna

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2015

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tom 15

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nr 1

41-44

EN

Venlafaxine is a drug with at least two significant antidepressant mechanisms of action. Selective serotonin reuptake inhibition (5-HT) is observed even when low doses are used and noradrenalin reuptake inhibition can be seen when doses are higher. The cut-off point is usually a daily dose of 225 mg although a change from one mechanism of action into dual action is usually of spectral nature. It is possible that in daily doses higher than 375 mg, the drug exhibits dopaminergic effects, but such large doses are not recommended by the manufacturer. Using higher doses is associated with greater antidepressant efficacy. One should remember, however, that a change of dosage can be related to a different profile of adverse effects (which also depends on patient’s individual sensitivity). The serotoninergic effects are also perceived as sedating, causing excessive drowsiness or even apathy. The noradrenergic effects can, however, evoke the feeling of excessive agitation and sleep disorders. Moreover, the perception of a given action, as indifferent or troublesome to functioning, depends on the time of a day at which it occurs. The sleep-inducing action is perceived as positive by patients in the evening and agitation may be considered positive in the morning. It seems that the time of using venlafaxine may affect the subjective drug tolerance. The article presents two cases that represent this viewpoint. It is not entirely clear why the action of the drug is experienced as the strongest by patients soon after administration (a specific placebo effect cannot be excluded). Despite this, subjective venlafaxine tolerance is undoubtedly associated with the manner of administration. Physicians should take this into consideration.

PL

Wenlafaksyna jest lekiem o co najmniej dwóch istotnych mechanizmach działania przeciwdepresyjnego. Hamowanie wychwytu zwrotnego serotoniny (5-HT) ujawnia się już podczas stosowania niskich dawek, a hamowanie wychwytu zwrotnego noradrenaliny – dopiero przy dawkach istotnie wyższych. Za punkt odcięcia przyjmuje się na ogół dawkę 225 mg na dobę, choć zmiana z jednego mechanizmu działania na dwa ma najprawdopodobniej charakter spektralny. Możliwe, że w dawkach powyżej 375 mg na dobę lek wykazuje również działanie dopaminergiczne, ale tak duże dawki wenlafaksyny nie są zalecane przez producenta. Stosowanie wyższych dawek przekłada się na większą skuteczność przeciwdepresyjną leku. Należy jednak pamiętać, że zmiana dawki może być związana z ujawnieniem się odmiennego profilu działań niepożądanych (choć zależy to także od indywidualnej wrażliwości pacjenta). Działanie serotoninergiczne bywa odbierane jako uspokajające, sedujące, powodujące nadmierną senność, a nawet zobojętnienie i apatię. Działanie noradrenergiczne może z kolei wywoływać uczucie nadmiernego pobudzenia i zaburzenia snu. To, czy dane działanie jest odczuwane jako niewpływające na funkcjonowanie, czy też jako trudne do zniesienia, zależy ponadto od pory dnia, w której występuje. Działanie nasenne pacjent uzna za korzystne wieczorem, natomiast działanie rozbudzające – rano. Wydaje się, że pora podawania wenlafaksyny może wpływać na subiektywną tolerancję leku. W artykule opisano dwie sytuacje ilustrujące ten punkt widzenia. Nie jest do końca jasne, dlaczego pacjenci odczuwają działanie leku najsilniej wkrótce po jego przyjęciu (nie da się wykluczyć swoistego efektu placebo). Mimo to w przypadku wielu chorych subiektywna tolerancja wenlafaksyny bez wątpienia ma związek ze sposobem podawania leku; lekarze powinni brać tę okoliczność pod uwagę.

9

Noradrenaline and learning - dependent cortical plasticity

63%

Edeline J. M.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 5

10

Age-dependent influence of prenatal stress on the catecholamine level in adrenals and blood glucose concentration in immobilized rats

63%

Beszczynska B. , Siejka A.

Acta Biologica Cracoviensia. Series Zoologia

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2008

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tom 50

43-48

11

Relationship between EMG, blood lactate, and plasma catecholamine thresholds during graded exercise in men

63%

Chwalbinska-Moneta J. , Kaciuba-Uscilko H. , Krysztofiak H. , Ziemba A. , Krzeminski K. , Kruk B. , Nazar K.

Journal of Physiology and Pharmacology

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1998

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tom 49

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nr 3

12

Blockade of nitric oxide formation impairs adrenergic-induced ACTH and corticosterone secretion

63%

Bugajski J. , Gadek-Michalska A. , Glod R. , Borycz J. , Bugajski A. J.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 2

13

Noradrenaline - and glutamate - induced taurine release from bulk isolated adult rat astrocytes

63%

Puka M. , Albrecht J. , Lazarewicz J. W.

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nr 1

14

Effect of L-NAME, a specific nitric oxide synthase inhibitor, on corticotropin-releasing hormone-elicited ACTH and corticosterone secretion

63%

Bugajski J. , Borycz J. , Gadek-Michalska A. , Glod R.

Journal of Physiology and Pharmacology

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1998

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tom 49

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nr 4

15

Mechanisms of catecholamine secretion from chromaffin cells

63%

Burgoyne R. D.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 3

16

Thapsigargin inhibits the effects of noradrenaline and high [Ca2]0 on kinetics but not on amplitude of contraction in the single myocytes of guinea pig heart

63%

Janiak R. , Lewartowski B.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 1

17

Influence of fasting on adrenal medullary reaction to diazepam

63%

Beszczynska B.

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tom 45

18

Lack of ovarian response in ageing cows to noradrenaline infused into the abdominal aorta

63%

Kotwica J. , Jaroszewski J. , Bogacki M.

Polish Journal of Veterinary Sciences

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2000

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tom 03

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nr 4

EN

A cannula was inserted into the aorta abdominalis through the coccygeal artery (cranial to the origin of the ovarian artery) in mature heifers (n=4) and in old cows (n=4) with reproductive disorders, to facilitate infusion of noradrenaline (NA; 4 mg/30 min) on day 10 of the oestrous cycle. Before, during and after NA jnfusion peripheral blood samples were collected for progesterone and oxytocin determination every 5-10 min. Each NA infusion stimulated (P < 0.01) secretion of both hormones in mature heifers. However, there were no hormonal response to NA treatment in ageing cows. In conclusion we assume that: (a) lack of ovary response to noradrenergic stimulation is involved in the reproductive disorders in the cow or (b) an ovary with disordered function does not respond to NA treatment, perhaps due to impairment of ß-adrenergic signalling system.

19

Endothelial no release caused by red wine polyphenols

63%

Stoclet J. C. , Kleschyov A. , Andriambeloson E. , Diebolt M. , Andriantsitohaina R.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 4

20

The development of the adrenal glands in grass snake [Natrix natrix L.] during early stages of its ontogenesis

63%

Rupik W.

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nr 1