Wyniki wyszukiwania - Biblioteka Nauki

1

Mały, a wielki pierwiastek - żelazo i jego rola w życiu człowieka

100%

Martula E. , Morak-Młodawska B. , Jeleń M.

Laboratorium - Przegląd Ogólnopolski

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2023

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tom nr 1

51--56

PL

Anemia, inaczej nazywana niedokrwistością jest jedną najczęściej występujących chorób hematologicznych. Dotyka osoby w każdym wieku: dzieci, dorosłych, a także osoby starsze. Stan ten jest następstwem pewnych zaburzeń dotyczących krwi. Zaliczamy do nich między innymi zbyt niski poziom hemoglobiny, obniżony hematokryt, czyli stosunek liczby czerwonych krwinek do pozostałych składników krwi, a także niski poziom erytrocytów - czerwonych krwinek. Krew osoby z anemią ma ograniczoną zdolność do transportu tlenu, czego efektem jest niedostateczne utlenowanie tkanek i narządów. Najczęściej występującą postacią niedokrwistości jest ta związana z deficytem żelaza, tzw. niedokrwistość syderopeniczna. Niedobór żelaza jest dość częstym zjawiskiem występującym wśród kobiet ze względu na ich fizjologię, ale może być również spowodowany dietą ubogą w ten pierwiastek. Niniejszy artykuł poświęcony żelazu ma za zadanie przybliżyć czytelnikowi, jak dużą rolę odgrywa w naszym organizmie, a także jak ważna jest jego prawidłowa suplementacja i jakie negatywne skutki może wywołać jego niedobór.

EN

Anaemia is one of the most common haematological diseases. It affects people of all ages: children, adults as well as the elderly. The condition is a consequence of certain disorders affecting the blood. These include too low a level of haemoglobin, a reduced hematocrit, or the ratio of red blood cells to other blood components, and a low level of erythrocytes - red blood cells. The blood of a person with anaemia has a reduced ability to transport oxygen, resulting in inadequate oxygenation of tissues and organs. The most common form of anaemia is that associated with iron deficiency known as sideropenic anaemia. Iron deficiency is quite common among women, due to monthly menstruation, but it can also be caused by a diet deficient in this element. This article on iron is intended to give the reader an idea of how big a role it plays in our bodies, the importance of its proper supplementation and the negative effects its deficiency con cause.

2

Nurses in Poland — immediate action needed

100%

Haczyński J. , Skrzypczak Z. , Winter M.

Engineering Management in Production and Services

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2017

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tom Vol. 9, no. 2

97--104

EN

The aim of the study is to analyse changes in the size of the population of nurses in Poland in the years 2004–2014, considering changes in their employment and the phenomenon of ageing. The analysis is based on the data published by the Central Register of Nurses and Midwives of the Central Statistical Office (GUS) and the Organisation for Economic Co-operation and Development (OECD). Nurses are the largest professional group in the healthcare sector. In 2014, only above 70% of licensed nurses were professionally active. The percentage of employed nurses compared to the number of licensed nurses varied between the lowest ratio of 65.1% in 2005 and the highest ratio of 71.7% in 2012. The latest ratio of 2014 was 70.9%, which was slightly lower compared to the highest ratio in 2012. The average age of a Polish nurse in 2008 was 44.19 years, increasing by about six years to 50.1 within the analysed period. The population of nurses aged above 65 years is almost 4.5 times bigger compared to the youngest age group, which is 21–25 years. Thus, 2/3 of the population of nurses are 41–60 years of age and nearly 85% are over 40. For two years (2000 and 2014), the number of practising nurses per 1000 inhabitants places Poland in the fifth bottom position among the European countries, which shows a significant reduction in patient access to nursing services. In Poland, the profession of nurses has no replacement generation. The article presents the shortage of professionally active nurses in Poland. The existing register of nurses does not contain complete information necessary to evaluate the current situation in Poland. There is a strong need to improve the tracking system of the register of nurses to accurately monitor the number of nurses in Poland The shortage of professionally active nurses and their ageing necessitates immediate action to reduce the shortage by increasing the appeal of the profession among young people and by encouraging nurses to return to the profession. It is also necessary to take action to delay the retirement of those nurses who want to work longer and to use their potential. This is also particularly important because of the gap in experience, which is going to become apparent the nearest future.

3

Niedobór i rozkład opadów w Siedlcach w latach 1971-2005

84%

Radzka E. , Koc G. , Rak J. , Jankowska J.

Przegląd Naukowy Inżynieria i Kształtowanie Środowiska

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2007

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tom Vol. 16, No. 3

33--38

EN

Meteorological data from 1971-2005 from a meteorological station situated in Siedlce coma from the Institute of Meteorology and Water Management (IMGW). In the present paper, the number of days with recorded precipitation was determined applying the criterion of Olechowicz-Bobrowska. In order to examine moisture excess and shortage a (P-ETR) index (climatic water balance) was calculated. Dry and wet months were determined following the Kaczorowska method. Sequences of days without rain were determined on the basis of Koźmiński criterion (1986). An average number of days with recorded precipitation (≥ 0.1 mm) during the growing season amounted to 83 days. The periods without rain over the growing seasons most and least frequently occurred in April, August and October, and in June respectively. The highest water shortages in the analysed multi-year period were recorded in May and August. The positive balance between precipitation and evaporation was observed only in the autumn months (September, October).

4

Znaczenie kwasu foliowego dla zdrowia organizmu człowieka

84%

Banyś K. J. , Knopczyk M. W. , Bobrowska-Korczak B.

Farmacja Polska

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2020

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tom 76

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nr 2

79-87

EN

A well-balanced diet is undoubtedly a key factor to maintain your body's normal state of health. A deficiency or excess of any nutrient can cause negative effects on human health. Folic acid is one of the elements of the diet, which is often supplied in insufficient quantities. This vitamin and its derivatives participate in the metabolism of amino acids and nucleic acids. Therefore, it is necessary for the proper functioning of the body's cells and for maintaining homeostasis, especially of the nervous, circulatory and cardiovascular systems. The biological activity of folic acid and its derivatives essentially affects the metabolism of important amino acids, such as methionine, homocysteine, serine, glycine, pyrimidine and purine synthesis and DNA methylation. The synthetic form of folic acid (most oxidized), which can be found in fortified foods, dietary supplements or pharmaceuticals, does not show biological activity. It is transformed in a series of reactions with the participation of many enzymes to form folates, which differ in the number of glutamic acid residues and the degree of oxidation. The actively biological form is reduced folate (L-5-MTHF), which is transported together with the blood to cells where it undergoes biological processes important for our health. The MTHFR gene, coding for the enzyme protein of the same name - methylene tetrahydrofolate reductase, is located on chromosome 1 at the 1p36.3 locus. This protein is responsible for the catalysis of the enzymatic reaction, which is the reduction of 5,10-methylenetetrahydrofolate to L-5-methyltetrahydrofolate, i.e. the active form of folate. This form is necessary in the process of homocysteine degradation, in the aftermath remethylation to methionine. This protein is responsible for the catalysis of the enzymatic reaction, which is the reduction of 5,10-methylenetetrahydrofolate to L-5-methyltetrahydrofolate, i.e. the active form of folate. This form is necessary in the process of homocysteine degradation, in the aftermath remethylation to methionine. However, according to available literature, mutation of the MTHFR 677C> T gene occurs in even 53% of the population. Among carriers of the TT genotype, it can cause about 70% reduction of MTHFR reductase activity. It is especially dangerous for people who do not provide adequate amounts of folic acid along with their diet and for those who need a high amount of this vitamin, e.g. due to taking medications that reduce its absorption, i.e. metformin or oral contraceptives. Many people metabolize folic acid on insufficient levels. For medical reasons, not the mutation itself is a problem, but too low the folate levels. In recent years, there is more and more discussion about the active form of folic acid and the possibility of effective supplementation with metapholine, which is a combination of calcium with L-5-MTHFR. It is a natural and reduced form of folate, which hydrolized and then transforms into L-5-MTHFR. Metapholine, in comparison to folic acid, is not reduced to be incorporated into metabolic processes in the cell, which is catalyzed by DHFR and MTHFR enzymes. In addition, the absorption of the active form of folic acid is faster because some metabolic pathways are missed. This is particularly important for people who have a MTHFR gene mutation homozygous with 665C> T and / or 1298A> C polymorphism and a mutation of the DHFR gene with 458A> T polymorphism. Numerous clinical studies have confirmed the efficacy and safety of the active form of folic acid. In a study by Houghton et al., which was conducted among pregnant Canadian women, L-5-MTHFR was shown to be at least as effective in lowering homocysteine levels as folic acid supplementation. In addition, the active form of folic acid was more effective at storing folate in erythrocytes. In a study conducted by Lamers et al. on 135 women after a period of 24 weeks, L-5MTHR was shown to be a suitable alternative in reducing plasma homocysteine levels compared to folic acid and placebo. In addition, Bentley et al. analyzed the results of 112 pregnant women from the USA. Patients were assigned to two groups in which each took vitamin B12. In addition, in one of them women supplemented with L-5-MTHFR, and in the other - folic acid. The results showed that patients who supplemented the active form of folic acid not only had higher hemoglobin levels, but also less often had anemia. When analyzing clinical trials of patients with the MTHFR mutation, the same trend was observed. Metafoline increased plasma folate levels and decreased homocysteine levels. In one study on German women, there was a decrease in homocysteine levels and an increase in folate levels in both plasma and red blood cells in patients who supplemented the active form of folic acid. In another study involving Swiss patients with the current 677CC MTHFR or 677TT MTHFR mutation, it was demonstrated that using L-5-MTHFR significantly reduces homocysteine levels compared to folic acid. It is also worth mentioning that Prinz-Langenhol et al. in a study on women with the 677CC and 677TT mutations proved that the active form of folic acid has a better effect on increasing folate levels than folate. It is also worth mentioning that folic acid at high doses can mask ailments or even diseases caused by vitamin B12 deficiency. In addition, folic acid administered at high doses in patients with the MTHFR mutation is not reduced to an oxidized, inactive form and is not properly transported to plasma. Non-metabolised folic acid can be dangerous to the human body and contribute to the development of cancer. Supplementation, in particular the active form of folic acid, should be considered by patients who are carriers of the MTHFR or DHFR mutation. In addition, the use of stimulants such as alcohol or nicotine also negatively affects the absorption of this vitamin. Taking some medications weakens the absorption of folic acid - these include folic acid antagonists, anti-tuberculosis drugs, hormonal oral contraceptives, nonsteroidal anti-inflammatory drugs or metformin widely used. Folic acid is necessary for the proper functioning of the human body and its deficiency may induce various disease processes in the body, which include: the formation of neural tube defects, disorders in the nervous system, megaloblastic anemia, a negative effect on the functioning of the cardiovascular system and the development of atherosclerosis and cancer. More and more people have anemia, including megaloblastic anemia, which is characterized by abnormal nucleic acid synthesis. The consequence of too low folate levels is impaired red blood cell production, an increase in their volume, and premature death. Extremely dangerous is megaloblastic anemia, the so-called malignant anemia in pregnant women, as it can lead to serious complications such as hemorrhage, infection, and even intrauterine fetal death. A significant influence of folic acid on the functioning of the nervous system has been proven in many clinical studies. This vitamin is involved in the formation of important neurotransmitters such as: adrenaline, dopamine and noradrenaline, therefore its deficiency may lead to the development of neuropsychiatric disorders (dementia, epilepsy, depression and psychosis). These disorders are often caused by high levels of homocysteine, which is not properly metabolized to methionine due to folate deficiency. An excess of homocysteine, as a consequence, leads to atherosclerosis in the cerebral arteries and, as a result of insufficient blood supply, transient ischaemic attack occur, which can contribute to the development of dementia or Alzheimer's disease. Nutritional observations indicate that eating fresh vegetables rich in folic acid protects against the formation of some cancers, e.g. large intestine, breast, ovary, uterus, lungs, pancreas. Deficiency of folic acid promotes the activation of protooncogenes to oncogenes, which in consequence results in a decrease in the stability of cellular DNA. A study carried out by Giovannicci et al. showed that excessive alcohol consumption and folic acid deficiency associated with it increased the risk of developing colorectal cancer by almost four times. However, what cannot be overlooked, the results of clinical trials show us that very high doses and folic acid accumulation favor the development of some cancers. It is thought that excess of folic acid may lead to hypermethylation of DNA and, consequently, to inactivation of the suppressor genes responsible for controlling cell division. Women in the pre-contraceptive period, during pregnancy and breastfeeding are included in the group of people with a special need for folic acid, in whom deficiency can cause many negative effects. The presence of folic acid is necessary in the process of cell formation and growth in the developing fetus, especially when the neural tube is forming. Moreover adequate folic acid concentration decreases risk of fetal heart and urinary tract defects, and also reduces the occurrence of thrombosis and miscarriage in pregnant women. Steeweg-de Graaff J. et al. conducted evaluation of emotional and behavioral development at the age of 3 depending on the concentration of folates and homocysteine in the mother's blood plasma at an early stage of the pregnancy. It was noted that with insufficient folate supply, associated with a lack of or its late supplementation increases the risk of emotional problems in children. In addition, defects of the nervous system may occur as a result of dysfunction of folate metabolism. In its transformation pathway MTHFR reductase takes a particular role. Its reduced activity contributes to the impairment of folic acid metabolism, and the MTHFR gene - type 677CC is considered a risk factor for the development of neural tube defects. Randomized study compared pharmacokinetic parameters of [6S]-5-MTHF and folic acid in healthy women of childbearing age with different MTHFR genotypes (677TT n = 6, 677CC n = 8). Higher peak folate concentrations in plasma with [6S]-5-MTHF supplementation was found, in comparison with folic acid and not depending in the MTHFR genotype, as well as a shorter time needed to reach maximum concentration. In a different randomized, double-blind trial significantly higher folate levels in red blood cells were obtained in women receiving [6S]-5-MTHF. Studies confirm the hypothesis that nutritional deficiencies are of great importance in terms of fetal development. The results testify the need of folic acid supplementation, in which it is worth to consider the use of biologically active form, 12 weeks before planned pregnancy. In the second and third trimesters, the supplementation of folic acid is an important element in prevention of anemia caused by vitamin B12 and folic acid deficiency, i.e. megaloblastic anemia. Moreover, it was found that folic acid at a daily dose of 400 - 800 μg reduce the risk of fetal neural tube defects. In its guidelines, Polish Society of Gynecologists and Obstetricians (PTGiP) recommends supplementation of 400 μg / day of folic acid in women in low risk group in the pre-contraceptive period, pregnancy and during breastfeeding and supplementation of 800 μg/ day of folic acid in women in intermediate risk group and also high risk group in II and III trimester and during breastfeeding. It is worth emphasising that in most recent guidelines, PTGiP pays attention to the problem of folic acid metabolism and emphasizes the appropriateness of supplementation with its active form, especially at high doses. In folic acid metabolism, MTHFR catalyzes the synthesis to the active form of folate (L-5-MTHFR). It is necessary in the process of homocysteine degradation following remethylation to methionine. Unfortunately, as a result of inappropriate methylation, e.g. as a result of active form of folic acid deficiency, the concentration of homocysteine in the blood serum increases, which is responsible for various pathogenic processes in the body. Insufficient supply and improper metabolism of folic acid, as well as vitamins B6, B12 deficiency may be factors favorable for development of atherosclerosis and other diseases related to the cardiovascular system (e.g. heart attack, stroke, coronary artery disease). Excessively high concentration of homocysteine in the blood plasma, caused by disorders of its metabolic pathway in the body, is one of the reasons for the formation of atherosclerotic changes in blood vessels. Excess of homocysteine, with a simultaneous deficiency of folate and vitamin B12, damages the endothelium of blood vessels and increases oxidation processes, which are associated with the development of inflammation, oxidation of LDL cholesterol and change in the structure of the walls of blood vessels. In addition, the risk of developing peripheral thrombosis and hypertension increases. In the meta-analysis of Linda L. et al. it was found that high concentration of homocysteine is an independent factor of developing coronary heart disease. In the majority of studies, the risk of this disease is increased by 20% to 50% with every increase of concentration of homocysteine by 5 μmol /L in the blood of the examined persons. To ensure proper functioning of blood vessels and to reduce the risk of cardiovascular disease, one needs to provide adequate concentration of homocysteine in the body. Folates and their adequate supply with diet or supplementation play a key role in this process. Looking at the numerous clinical studies, available literature and the function of folic acid, it can be stated that it is an essential compound with multidirectional biological action, which is involved in the synthesis of amino acids and nucleic acids important for health. It plays an important role in tissues, such as: the fetus, hematopoietic system and gastrointestinal epithelium, in which cell divisions occur. For this reason, the presence of folic acid in the right amounts, ensures the proper functioning of our body. A deficiency of folic acid in the diet leads to a reduced concentration of folate in plasma and red blood cells. It is a condition that contributes to the formation of many serious diseases in our body and congenital neural tube defects in the fetus. As clinical studies have shown, the optimal concentration of folates in the blood reduces the risk of cardiovascular, circulatory, central nervous system diseases and certain types of cancer. To reduce the risk of diet-related diseases caused by folic acid deficiency, daily diet should be optimally balanced and contain products rich in natural folates. If diet is an insufficient source of folic acid, its supplementation should be considered, with the possible inclusion of its active form. Supplementation is recommended, in particular, for people with: megaloblastic anemia, diabetes mellitus, malabsorptions (e.g. Crohn's disease), alcoholism, malnutrition, neurodegenerative diseases (e.g. Alzheimer's disease), cardiovascular diseases, elevated homocysteine levels and using certain medications (e.g. oral contraceptives, metformin, methotrexate). It is also worth mentioning that metapholine supplementation bypasses the multistage metabolic process before incorporating folates into the cell cycle, as opposed to the inactive form of folic acid. This is particularly important for patients with the DHFR and MTHFR mutation, which depending on the polymorphism, may occur in up to 53% of the Caucasian population. Consequently, MTHFR reductase activity is reduced by up to 70%.

PL

Kwas foliowy jest niezbędny do właściwego funkcjonowania organizmu i zachowania homeostazy. Uczestniczy w metabolizmie kwasów nukleinowych, aminokwasów, syntezie pirymidyn i puryn. Syntetyczna postać kwasu foliowego nie wykazuje aktywności biologicznej. Przekształcana jest w szeregu reakcji do postaci folianów (L-5-MTHF) które, są transportowane do komórek, gdzie bierze udział w ważnych procesach biologicznych. Gen MTHFR odpowiedzialny jest za katalizę reakcji enzymatycznej: redukcję 5,10-metylenotetrahydrofolianu do aktywnej formy. Mutacja genu MTHFR 677C>T występuje nawet u 53% populacji czego konsekwencją jest zmniejszenie aktywności reduktazy – MTHFR nawet o 70%. Metafolina (aktywna forma) w przeciwieństwie do kwasu foliowego, aby zostać włączona do procesów metabolicznych w komórce, nie ulega redukcji, katalizowanej przez DHFR oraz MTHFR. Jest to istotne w szczególności dla osób, które mają mutację genu MTHFR oraz DHFR. Przyjmowanie niektórych leków osłabia wchłanialność kwasu foliowego. Kwas foliowy jest niezbędny do prawidłowego funkcjonowania organizmu człowieka a jego niedobór może indukować różne procesy chorobowe w organizmie, do których zaliczamy: powstawanie wad cewy nerwowej, zaburzenia w układzie nerwowym, niedokrwistość megaloblastyczną, negatywny wpływ na funkcjonowanie układu sercowo – naczyniowego oraz rozwój miażdżycy i nowotworów. Witamina ta bierze udział w powstawaniu ważnych neuroprzekaźników, takich jak: adrenalina, dopamina i noradrenalina, dlatego jej niedobór może prowadzić do powstania zaburzeń neuropsychiatrycznych. Niedobór kwasu foliowego sprzyja aktywacji protoonkogenów do onkogenów. Liczne badania kliniczne i dostępna literatura potwierdzają funkcję kwasu foliowego, że jest to niezbędny związek o wielokierunkowym działaniu biologicznym, który pełni istotną rolę w tkankach. Suplementacja metafoliną omija wieloetapowy proces metaboliczny w przeciwieństwie do nieaktywnej postaci kwasu foliowego.

5

Context of the inventory management expenses in the case of planned shortages

67%

Korponai J. , Tóth Á. B. , Illés B.

Engineering Management in Production and Services

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2017

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tom Vol. 9, no. 1

26--35

EN

The main purpose of the paper is to present the relations between the different cost factors of the inventory management systems, and the context between the order quantities and the cost level. The theoretical approach of the model assumes a deterministic operational environment with planned shortages. We make the examination of the contexts by applying the ceteris paribus principle; we change only one cost factor from among the initial conditions at once and examine its effect on the cost level. By using the economic order quantity with the planned shortage model, we can define the optimal order quantity, along which our stock management can be guaranteed by the most favourable cost level. The optimisation of the inventory level and the inventory management expenses together means an important factor in the competitiveness of the company. During the definition of the optimal inventory level of purchased parts, the purchasing and stock holding costs, and also the consequence of shortages play an important role. The presentation of the specific expense factors in each other’s function, and the representation of the onetime order expenses show their proportion compared to each other and the effect of their change on the total cost, and define the opportunities of the optimisation. The significance of the model is that it represents the level line of costs, the movement of the different cost factors in relation to others and their operating mechanism. Thus, it facilitates the representation of costs and the definition of the direction of optimisation.

6

Niedobór wody i żywności na Bliskim Wschodzie i w Afryce Północnej a perspektywy współpracy regionalnej

67%

Zdanowski J.

Krakowskie Studia Międzynarodowe

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2018

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nr 4

139-155

EN

The Middle East and North Africa is facing serious development problems. The cause of many of them are largely natural phenomena, which are more and more often referred to as the new paradigm of regional development and points to the need to strengthen regional cooperation to limit the negative eﬀ ects of these phenomena. One of them is the shortage of water, which has a negative impact on food production and agriculture, which is the main occupation of the region’s population. The situation in terms of access to water worsens as a result of climate warming, rising sea levels and decreasing amounts of precipitation. An additional factor is the expected doubling of the number of inhabitants of the region until 2050, which will increase the demand for water. Access to water resources has become a policy tool and a source of conflicts and wars. The most difficult situation is in this respect in the bass of Tigris and Euphrates and the Nile. A positive example is the cooperation of the Gulf Council States (GCC) in the production of drinking water from the sea and the more rational use of resources through recycling.

PL

Bliski Wschód i Afryka Północna to region, który boryka się z poważnymi problemami rozwojowymi. Ich przyczyną w dużej mierze są zjawiska naturalne, o których mówi się coraz częściej jako o nowym paradygmacie rozwoju regionu. Wskazuje się także na konieczność zacieśnienia współpracy regionalnej w celu ograniczenia negatywnych skutków tych zjawisk. Jednym z nich jest niedobór wody, który rzutuje negatywnie na możliwości produkcji żywności i rolnictwo, będące głównym zajęciem ludności regionu. Sytuacja w zakresie dostępu do wody pogarsza się w następstwie ocieplania się klimatu, podnoszenia się poziomu morza i zmniejszania się ilości opadów atmosferycznych. Dodatkowym czynnikiem jest spodziewane podwojenie się liczby mieszkańców regionu MENA do 2050 r., co spowoduje wzrost zapotrzebowania na wodę. Dostęp do jej zasobów stał się narzędziem polityki, a także przyczyną konﬂ iktów oraz wojen. Najtrudniejsza sytuacja pod tym względem jest w basenie Tygrysu i Eufratu oraz Nilu. Pozytywną odpowiedzią na problem niedoboru wody jest kooperacja państw Rady Współpracy Zatoki (GCC) w pozyskiwaniu wody pitnej z wody morskiej oraz bardziej racjonalne jej wykorzystanie w drodze recyklingu.

7

Prognoza strategii Bundeswehry w dobie niedoboru ropy naftowej

67%

Czarnota Z. , Moszumański Z.

Wiedza Obronna

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2011

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tom nr 4

18--27

8

Ocena stężenia witamin antyoksydacyjnych u osób z zespołem metabolicznym pracujących w rolnictwie

67%

Godala M. , Gaszyńska E. , Moczulski D. , Materek-Kuśmierkiewicz I. , Krzyżak M.

Medycyna Pracy

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2021

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tom 72

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nr 2

123-129

EN

Background: Vitamins A, C and E are important parts of the antioxidant barrier. Polish data on antioxidant vitamins deficiency in the population are rare, especially among physically active people with metabolic disorders. The aim of this study was to evaluate the serum concentrations of vitamins A, C and E in people with metabolic syndrome (MS) working in agriculture, the prevalence of their deficiency in these workers, and the correlation between antioxidant vitamins concentration and traditional biomarkers of cardiovascular diseases. Material and Methods: The study included 332 residents of the Łódź Voivodeship working in agriculture: 231 people with MS and 101 healthy ones. The serum concentrations of vitamins A, C and E were assessed using the chemiluminescent immunoassay technology. The antioxidant vitamins intake was assessed by means of a 24-h recall questionnaire using Diet 5.0 software. Results: The mean serum concentrations of vitamins A, C and E were significantly lower in the MS workers than in the healthy ones No correlation was found between the antioxidant vitamins concentration and the dietary intake but there was a correlation between the antioxidant vitamins concentration and high-density lipoprotein cholesterol (HDL-C). A correlation was found between the serum concentrations of vitamins A and C, and vitamins A and E, in the MS workers. Conclusions: The serum concentrations of antioxidant vitamins in the MS workers were significantly lower than in the healthy controls, despite the similar physical activity level. The dietary intake had no impact on the serum concentrations of these vitamins. The HDL-C concentration in the MS workers correlated with the concentrations of all antioxidant vitamins.

PL

Wstęp: Witaminy A, C i E stanowią ważną barierę antyoksydacyjną. Danych dotyczących stanu odżywienia populacji polskiej witaminami antyoksydacyjnymi jest niewiele, a szczególnie mało dotyczy osób aktywnych fizycznie z zaburzeniami metabolicznymi. Celem badania była ocena stężenia witamin A, C i E w surowicy krwi i częstości ich niedoborów u osób z zespołem metabolicznym (ZM) pracujących w rolnictwie oraz zależności między stężeniem witamin antyoksydacyjnych w surowicy a tradycyjnymi biomarkerami chorób sercowo-naczyniowych. Materiał i metody: W badaniu wzięło udział 332 mieszkańców województwa łódzkiego pracujących w rolnictwie: 231 osób z ZM i 101 osób zdrowych. Stężenie witamin A, C i E w surowicy krwi badano za pomocą wysokosprawnej chromatografii cieczowej, a spożycie witamin z dietą oceniano za pomocą programu Dieta 5.0 na podstawie 24-godzinnych wywiadów żywieniowych. Wyniki: Średnie stężenia witamin A, C i E w surowicy krwi osób z ZM były istotnie mniejsze niż w grupie bez ZM. Stężenie nie korelowało ze spożyciem witamin z dietą, ale korelowało ze stężeniem cholesterolu HDL. Stwierdzono korelację między stężeniem w surowicy witamin A i C oraz A i E u pracowników z ZM. Wnioski: Stężenie witamin antyoksydacyjnych w surowicy pracowników z ZM było istotnie mniejsze niż w grupie osób zdrowych, mimo podobnego poziomu aktywności fizycznej. Wysokie spożycie witamin z dietą nie różnicowało ich stężenia w surowicy osób z ZM zatrudnionych w rolnictwie. Stężenie cholesterolu HDL u osób z ZM korelowało ze stężeniem wszystkich witamin antyoksydacyjnych.

9

Ocena stężenia 25(OH)D u osób z zespołem metabolicznym pracujących w rolnictwie

67%

Godala M. , Gaszyńska E. , Moczulski D. , Materek-Kuśmierkiewicz I. , Krzyżak M.

Medycyna Pracy

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2021

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tom 72

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nr 1

9-18

EN

Background: Polish data on vitamin D deficiency in the population are incomplete. Vitamin D deficiency seems to be common, but there is a lack of studies concerning the concentration of 25(OH)D in people with high UV exposure. The aim of this study was to evaluate the plasma concentration of 25(OH)D in people with and without metabolic syndrome (MS), working in agriculture, the prevalence of its deficiency in these workers, and the correlation between the plasma concentration of 25(OH)D and traditional biomarkers of cardiovascular diseases. Material and Methods: The study included 332 people working in agriculture in the Łódź voivodeship, including 231 people with MS and 101 healthy ones. The plasma concentration of 25(OH)D was assessed using the chemiluminescent immunoassay technology. The vitamin D intake was assessed using a 24-h recall questionnaire using Diet 5.0 software. Results: The mean plasma concentration of 25(OH)D was 13.64±8.01 ng/ml in MS workers, and it was significantly lower than in the healthy ones (26.61±10.12 ng/ml, p < 0.00001); the highest concentration of 25(OH)D was noted in summer months. Deficient plasma concentrations of 25(OH)D were found significantly more often in MS workers than in the controls (81.82% and 20.79%, respectively, p < 0.00001). No correlation was found between the plasma vitamin D concentration and its dietary intake. The plasma concentration of 25(OH)D correlated with age of the examined workers (r = –0.28, p = 0.023), high density lipoprotein concentration (r = 0.19, p = 0.036) and glucose concentration (Rho = –0.24, p = 0.02). A multivariate analysis of variance demonstrated that the body mass index affected significantly the mean value of the 25(OH)D concentration in MS workers. Conclusions: The concentration of vitamin D in the plasma of workers with MS was significantly lower than in the healthy controls despite the same high UV exposure; these workers also manifested significantly higher 25(OH)D deficiency than the control subjects. This study indicates the need for further research on the concentration of 25(OH)D in people with metabolic disorders regardless of UV exposure and vitamin D intake with a diet.

PL

Wstęp: Dane dotyczące stanu odżywienia witaminą D populacji polskiej są niepełne. Niedobory witaminy D wydają się powszechne, jednak nie odnaleziono polskich badań, które weryfikowałyby stężenie 25-hydroksywitaminy D [25(OH)D] u osób intensywnie eksponowanych na promieniowanie ultrafioletowe (UV). Celem pracy była ocena stężenia 25(OH)D w osoczu osób z zespołem metabolicznym (ZM) pracujących w rolnictwie, częstość jej niedoborów u tych osób oraz zależność między stężeniem 25(OH)D w osoczu a tradycyjnymi biomarkerami chorób sercowo-naczyniowych. Materiał i metody: W badaniu wzięło udział 332 mieszkańców województwa łódzkiego pracujących w rolnictwie, w tym 231 osób z ZM i 101 zdrowych. Stężenie 25(OH)D w osoczu oceniano z użyciem testu wykorzystującego technologię chemiluminescencyjnych testów immunologicznych. Spożycie witaminy D z dietą oceniano za pomocą programu Dieta 5.0 na podstawie 24-godzinnych wywiadów żywieniowych. Wyniki: Średnie stężenie 25(OH)D w osoczu pracowników z ZM wynosiło 13,64±8,01 ng/ml i było istotnie niższe niż w grupie badanych bez ZM (26,61±10,12 ng/ml, p < 0,00001). Najwyższe średnie stężenie 25(OH)D odnotowano w miesiącach letnich. U pracowników z ZM istotnie częściej niż w grupie bez ZM stwierdzono deficytowe stężenie 25(OH)D w osoczu (odpowiednio, 81,82% i 20,79%, p < 0,00001). Stwierdzono brak korelacji między stężeniem 25(OH)D a jej spożyciem z dietą. Stężenie 25(OH)D korelowało z wiekiem (r = –0,28, p = 0,023) oraz stężeniami cholesterolu HDL (r = 0,19, p = 0,036) i glukozy (Rho = –0,24, p = 0,02) w badanej grupie rolników. Wieloczynnikowa analiza wariancji wykazała, że u pracowników z ZM czynnikiem wpływającym istotnie na średnią wartość stężenia 25(OH)D był wskaźnik masy ciała. Wnioski: Stężenie witaminy D w osoczu osób z ZM było istotnie mniejsze niż u osób zdrowych mimo jednakowej, wysokiej ekspozycji na promieniowanie UV. Ponadto u osób z ZM istotnie częściej stwierdzano deficytowe stężenie 25(OH)D niż u badanych bez ZM. Uzyskane wyniki wskazują na konieczność prowadzenia dalszych badań dotyczących stężenia 25(OH)D u osób z chorobami metabolicznymi, niezależnie od wielkości ekspozycji na promieniowanie UV i spożycia witaminy D z dietą.

10

Prawdziwa wartość słodkiej wody

59%

Pewiński S.

Wodociągi - Kanalizacja

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2021

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tom nr 4

26--28

11

Zjawisko niedoboru kobiet w Azji – zarys problemu na przykładzie Chin i Indii

51%

Kusztal A.

Studia Krytyczne/ Critical Studies

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2015

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nr 1

131-145

PL

Celem niniejszego artykułu jest przybliżenie budzącego coraz większe zaniepokojenie demografów i decydentów zjawiska niedoboru kobiet w populacjach wielu państw Azji, ze szczególnym uwzględnieniem przodujących w eskalacji tego zjawiska Chin i Indii. Tezą prezentowanego wywodu jest stwierdzenie, że omawiane zjawisko będzie mieć w przyszłości bardzo negatywne konsekwencje społeczne, ekonomiczne i polityczne dla obu państw, które mimo wieloletnich starań nie chcą, nie potrafią lub nie są już w stanie odwrócić negatywnych trendów demograficznych. W artykule omówiono kolejno: specyfikę i skalę zjawiska, jego usytuowanie przestrzenne, bezpośrednie – fizyczne i pośrednie – kulturowe, religijne i obyczajowe przyczyny negatywnego trendu, ale także podejmowane próby przeciwdziałania niekorzystnym tendencjom oraz ich obecne i potencjalne skutki.

EN

The purpose of this article, is to introduce – awakening a growing concern of demographers and policy-makers – phenomenon of the deficiency of women in the populations of many countries in Asia, with a particular focus – leading in an escalation of this phenomenon – China and India. The thesis of the present paper is that the phenomenon will have in the future a very negative social, economic and political consequences to the two countries, which, despite many years of efforts, can not or are no longer able to reverse the negative demographic trends. The article discusses: the specificity and scale of the phenomenon, its spatial location, direct – physical and indirect – cultural, religious and moral reasons for the negative trend, but also presents attempts to counter negative trends and their current and potential impact on the society