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NEUROMARKERS OF ANXIETY IN A PATIENT WHO HAD EXPERIENCED A TRANSIENT ISCHEMIC ATTACK (TIA) OF THE LEFT BRAIN HEMISPHERE AS A RESULT OF A CRITICAL STENOSIS OF THE INTERNAL CAROTID ARTERY (ICA) PERATED ON BY ENDARTERECTOMY (CEA)

100%

Wilczek-Rużyczka E. , Mirski A. , Korab M. , Trystuła M.

Acta Neuropsychologica

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2021

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tom 19(1)

1-9

EN

The search for neuromarkers is a very promising way to improve psychiatric and psychological care. They are now considered to be an innovative diagnostic tool in psychiatry and neuropsychology, but more broadly in all human health sciences. The aim of our study was to find the neuromarker of anxiety in a patient who had experienced a Transient IschemicAttack (TIA) of the left brain hemisphere as a result of a critical stenosis of the Internal Carotid Artery (ICA) operated on byendarterectomy (CEA). We will present the case of a 54-year-old man,an architect, who experienced a Transient Ischemic Attack (TIA) of the left brain hemispherecaused by a critical stenosis of theInternal Carotid Artery (ICA) and was treated successfully with surgical endarterectomy (CEA). One year after the surgery itself, the patient developed severe postoperative anxiety, headaches, difficulty in sleepingas well as the inability to continue working in his profession. Strong anxiety was notedon the adapted 100-millimeter Visual Analogue Anxiety Scale (VAAS). The patient was assessed using the Human Brain Index (HBI) methodology (Kropotov 2009; 2016; 2017; Pąchalska, Kaczmarek&Kropotov 2014) which consisted of recording 19-channel EEG in resting state conditions, during the cued GO/NOGO task and comparing the parameters of EEG spectra and Event-Related Potentials (ERPs) with the normative and patient databases of the Human Brain Index(HBI). No signs of cognitive dysfunction was found, however an excessive Rolandic beta was observed. In line with the working hypothesis as to the presence of an anxiety neuromarker, the patient’s studies confirmed an increased P1 time wave in the left hemisphere of the brain in ERP in response to visual stimuli, i.e. an anxiety neuromarker. Following the detection of this neuromarkera specific anodic Transcranial Direct Current Stimulations (tDCS) pro- tocol was proposed (see: Kropotov 2016; Pąchalska, Kaczmarek & Kropotov 2020). Ten tDCS sessions were performed and the postoperativeanxiety was found to be resolved. The patient returned to work. The use of Human Brain Index (HBI) methodologyenabling the isolation of the Event Related Potentials (ERPs) patterns revealed the presence of a distinct anxietyneuromarker. Neurotherapy with the use of tDCS allowed the reduction of anxiety symptoms and the patient’s return to work. The above case study indicates the necessity to use new neurotechnologies in the diagnosis of mental diseases, with particular emphasis on postoperative anxiety. ------------------------------------------------------------------------------------------------------------------------------------

2

NEUROPSYCHOLOGY OF CREATIVITY: A MICROGENETIC APPROACH

86%

Pąchalska M.

Acta Neuropsychologica

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2022

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tom 20(1)

87-114

EN

The neuropsychology of creativity is recently understood as a subdiscipline developing on the borderline of being a: (1) medical neuroscience - using clinical and experimental neuroanatomical, neurophysiological, neurobiological, neurosurgical, neurological, neuropsychiatric methods and approaches and (2) social neuroscience - using social psychology and neuropsychology, social linguistics and neurocultural studies to help disabled people. The subject of research into the neuropsychology of creativity is the relationship between creativity and the functioning of the brain (structures and neuronal connections) and the self using the individual, social and cultural mind and modelling these behaviors in relation to the biological organism and the social and cultural environment itself. Neuropsychological research of creativity is directed mainly to discover the brain mechanisms of creativity, to form the theoretical models, to elaborate the methods of diagnosis and therapy of artists with brain damage. A promising model that allows for a better understanding of the creation process, and therefore one offering better assistance to individuals who have never developed or have lost the ability to create due to brain damage, is the microgenetic approach that will be discussed in this article. To introduce the reader to these issues, a case study of an artist with brain damage is presented. It illustrates the importance of performing a syndrome analysis, supported by the neurophysiological studies (neuroimaging studies of the brain, quantitative electroencephalography (qEEG), event-related potentials (ERPs) and sLorette tomography) with the use of neuromarkers to avoid a false diagnosis. It also shows the possibilities of art therapy in the process of rebuilding the creative abilities lost as a result of brain damage, and thus the rebuilding of one's individual, social and cultural Self. However, something that is also important for artists, selected works, especially the most characteristic and significant ones, are also achieving critical recognition. It even happens that they become a part of the world's cultural heritage, are displayed at various exhibitions and are even bought to be hung in the collections of galleries acrosss the world, like in the case of the artist presented in these paper.

3

Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma

72%

Nowicki M. , Miskowiak B.

Folia Histochemica et Cytobiologica

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2002

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tom 40

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nr 3