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1
Content available remote Antitumor chemical constituents of Toddalia asiatica (Linn) Lam root bark and its rational alternative medicinal parts by multivariate statistical analysis
100%
Luo C. , Liu J. , Liang Y. , Shen X. , Zhang X. , Zhou W.
Acta Chromatographica
|
2021
|
tom Vol. 33, no. 2
153--161
EN
Toddalia asiatica (Linn) Lam (T. asiatica) as a traditional Miao medicine was investigated to find rational alternative medicinal parts for T. asiatica root bark and its antitumor chemical constituents by quantitative pharmacognostic microscopy, high performance liquid chromatography (HPLC) fingerprint and multivariate statistical analysis. A bivariate correlation analysis method based on microscopic characteristics and content of chemical constituents was established for the first time, there were some regular discoveries between powder microscopic characteristics and common chromatographic peaks of T. asiatica through quantitative pharmacognostic microscopy, cork cells, calcium oxalate square crystal, brown clump, starch granule and phloem fiber, as powder microscopic characteristics may be placed where the main chemical constitutes were enriched. Scores plot of principal component analysis (PCA) and dendrogram of hierarchical clustering analysis (HCA) showed that 18 T. asiatica samples were distinguished correctly, clustered clearly into two main groups as follows: S01∼S03 (root bark) and S07∼S09 (stem bark) in cluster 1, S04∼S06 and S10∼S18 in cluster 2. Nineteen common peaks were obtained in HPLC fingerprint of T. asiatica, loadings plot of PCA indicated seven compounds played important roles in different part of samples (P10 > P08 > P07 > P14 > P16 > P17 > P19), peaks 04, 06, 07, 08, 10 were identified as hesperidin, 4-methoxycinnamic acid, toddalolactone, isopimpinlline and pimpinellin. MTT assay was used to determine the inhibitory activity of different medicinal parts of T. asiatica on human breast cancer MCF-7 cells, all parts of T. asiatica had different inhibitory effects on MCF-7 cell lines, root and stem barks of T. asiatica showed the best inhibitory activity. The relationship between chemical constituents and the inhibitions on MCF-7 cell had been established, significant antitumor constituents of T. asiatica were identified by correlation analysis, the order of the antitumor effect of the main compounds was P07 (toddalolactone) > P16 > P06 (4-methoxycinnamic acid), P11 > P18 > P10 (pimpinellin) > P08 (isopimpinellin) > P01 > P19 > P14 > P04 (hesperidin) > P17, which were antitumor chemical constituents of T. asiatica root bark. T. asiatica stem bark was the most rational alternative medicinal part for T. asiatica root bark.
2
Content available remote Rapid comparison of antitumor chemical constituents and mechanisms between Dendrobium nobile and Dendrobium officinale by UPLC-IT-TOF, network pharmacology and experimental verification
100%
Liu J. , Li Z. , Zeng M. , Liang Y. , Liang B. , Ge Q. , Zhang X. , Zhang S. , Zhou W.
Acta Chromatographica
|
2023
|
tom Vol. 35, no. 2
123--138
EN
Dendrobium nobile and Dendrobium officinale as the main varieties of traditional Chinese medicine Dendrobium are widely used in clinic. The study aimed to systematically explore chemical constituents and their antitumor effect of D. nobile and D. officinale by ultra-performance liquid chromatography coupled with ion trap time-of-flight mass spectrometry (UPLC-IT-TOF), network pharmacology and cancer cell experiments. D. nobile extract and D. officinale extract could significantly inhibit the proliferation of human lung cancer A549 cells, human liver cancer HepG2 cells and human breast cancer MCF-7 cells in the dose-dependent manner (P < 0.05), the antitumor effect of D. officinale extract was stronger than that of D. nobile extract at the same drug concentration. A total of 40 chemical constituents of D. nobile and D. officinale including phenanthrenes, bibenzyls and other types of compounds had been identified by UPLC-IT-TOF, LCMSsolution and MetID software according to retention times, accurate mass, MSⁿ fragmentation, reference compounds and natural product databases. Phenanthrenes with good antitumor activity were mainly present in D. nobile, bibenzyls were the main compounds of D. officinale. Integrated networks of Herb-Compounds-Targets-Cancer revealed that gigantol, moscatilin, tristin, moscatin and densiflorol B were regarded as key antitumor compounds of D. nobile and D. officinale, D. nobile and D. officinale shared 7 targets accounting for 70% of the antitumor core targets, more than half of their antitumor KEGG pathways were similar. The results of molecular docking and western blotting experiments indicated that the antitumor mechanisms of D. nobile and D. officinale may be through inhibiting PI3K-Akt and HIF-1α signaling pathways.
3
Content available remote O historii leków naturalnych na łamach „Kroniki Farmaceutycznej” w okresie dwudziestolecia międzywojennego (1919 -1939)
72%
Ślusarczyk W.
Kwartalnik Historii Nauki i Techniki
|
2018
|
tom R. 63, nr 1
39--63
EN
In the years 1919-1939, „Kronika Farmaceutyczna” was the press organ of the Trade Union of Pharmaceutical Employees of the Republic of Poland. The magazine was filled with articles devoted to defence of pharmacists’ rights but the aim of its editors was also to publish scientific and popular content, in which a prominent place was occupied by articles on the history of natural medicines. This work attempts to analyse the forms and content of that kind of articles: describe how the subject of old medicines was written about, what types of medicines were discussed, and also who and why wrote about them. Articles devoted to the history of natural medicines can be divided in four categories: scientific and popular articles dedicated to current pharmaceutical issues and preceded by historical introductions; scientific and popular articles on history; summaries from foreign pharmaceutical magazines and news from the world covering pharmaceutical problems of the time, accompanied by historical introductions, as well as summaries from foreign pharmaceutical magazines and historical news from the world. According to our research, the majority of analysed articles belonged to the first category. Articles concerning the past of natural medicines appeared throughout the interwar period and became a permanent element of “Kronika Farmaceutyczna”. They focused on plant drugs, less often on zoonotic and mineral ones. Majority of texts were written according to a pattern based on chronological narration. Historical content was supplemented with ancient mythology information and folk medicine. Abundance of information obtained from contemporary literature dealing with this subject and from the sources proves that authors were undoubtedly erudite people. They committed some mistakes from time to time, though. Their errors, as well as uncomplicated, chronological system of narration were the results of the fact that they were not professional historians but pharmacists. Their interest in the past of natural medicines was to a large extent the outcome of general tendencies predominant in the Polish pharmaceutical milieu at that time. Analysed publications were therefore written by pharmacists and for pharmacists. Their purpose, aside from satisfying readers’ curiosity, was to deepen professional knowledge through enabling the perception of current pharmaceutical problems from the larger, historical perspective.
4
O historii leków naturalnych na łamach „Kroniki Farmaceutycznej” w okresie dwudziestolecia międzywojennego (1919–1939)
72%
Ślusarczyk W.
Kwartalnik Historii Nauki i Techniki
|
2018
|
tom 63
|
nr 1
39–63
EN
In the years 1919‒1939, „Kronika Farmaceutyczna” was the press organ of the Trade Union of Pharmaceutical Employees of the Republic of Poland. The magazine was filled with articles devoted to defence of pharmacists’ rights but the aim of its editors was also to publish scientific and popular content, in which a prominent place was occupied by articles on the history of natural medicines. This work attempts to analyse the forms and content of that kind of articles: describe how the subject of old medicines was written about, what types of medicines were discussed, and also who and why wrote about them. Articles devoted to the history of natural medicines can be divided in four categories: scientific and popular articles dedicated to current pharmaceutical issues and preceded by historical introductions; scientific and popular articles on history; summaries from foreign pharmaceutical magazines and news from the world covering pharmaceutical problems of the time, accompanied by historical introductions, as well as summaries from foreign pharmaceutical magazines and historical news from the world. According to our research, the majority of analysed articles belonged to the first category. Articles concerning the past of natural medicines appeared throughout the interwar period and became a permanent element of “Kronika Farmaceutyczna”. They focused on plant drugs, less often on zoonotic and mineral ones. Majority of texts were writ¬ten according to a pattern based on chronological narration. Historical content was supple¬mented with ancient mythology information and folk medicine. Abundance of information obtained from contemporary literature dealing with this subject and from the sources proves that authors were undoubtedly erudite people. They committed some mistakes from time to time, though. Their errors, as well as uncomplicated, chronological system of narration were the results of the fact that they were not professional historians but pharmacists. Their interest in the past of natural medicines was to a large extent the outcome of general tendencies predominant in the Polish pharmaceutical milieu at that time. Analysed publications were therefore written by pharmacists and for pharmacists. Their purpose, aside from satisfying readers’ curiosity, was to deepen professional knowledge through enabling the perception of current pharmaceutical problems from the larger, historical perspective.
5
Content available Zastosowanie lecznicze i kosmetyczne wody różanej według dziewiętnastowiecznej literatury farmaceutycznej oraz medycznej
72%
Koniewicz K.
|
2021
|
tom 28
7-21
EN
Floral water, also called hydrolate, is a secondary product of the distillation process of aromatic plants. In the Middle Ages, rose hydrolate, according to medical advice of the time, protected against plague spread by ‘miasma’. In nineteenth-century medical and cosmetic applications, rose water was often used as an aromatic and soothing ingredient, forming a base while giving the product the right consistency. It was also the main ingredient in eye medications (in Latin: Collyrium), anti-inflammatory ointments and cosmetic products, including perfumes, aromatic waters, nourishing creams, lubricating pomades and numerous fragrances. In the 19th century medical and pharmaceutical literature, rose water was seen as a mainly aromatic substance which added a pleasant fragrance to medicines and cosmetics. The aim of this article is to compare the recipes for medicines and cosmetics containing rose water from 19th-century apothecary’s manuscripts in the library of the Pharmacy Museum of the Jagiellonian University Medical College with the medical and pharmaceutical literature of the period.
6
Content available „Uniwersytet zdrowia” w Kosowie. O działalności Apolinarego Tarnawskiego
72%
Jarząbek-Wasyl D.
Pomiędzy. Polonistyczno-Ukrainoznawcze Studia Naukowe
|
2015
|
nr 1
81-95
UK
У статті йдеться про доктора Аполінарія Тарнавського (1851-1943), польського піонера природолікування, засновника та багатолітнього керівника так званої „Лічниці" (Zakład Zdrowia) у серці Карпат. Принципи природолікуваних методів (повітряні, водяні та сонячні ванни, дієта і фізичні вправи) були пов'язані з домінуючими тенденціями у санаторіях 3ахідної європи, проте, завдяки винахідливісті лікаря-візіонера у Косові, вони використовували авторської програми власника закладу, який вважав голод та працю найкращими медикаментами. Таким чином лікар із Косова випередив своїх сучасників на багато років та мав чималий вплив на суспільне життя Польщі у міжвоєнному періоді. Косівська „Лічниця" відіграла помітну роль серед польської інтелігенцї, адже пацієнтами клініки були представники відомих польських родин. Окрім того, її історія повязана зі спільним, польсько-українським, минулим Косівщини. Адже саме тут пропагувався здоровий спосіб життя задовго до европейської моди.
EN
The article is devoted to dr Apolinary Tarnawski (1851-1943), Polish pioneer of natural medicine, the founder and for fifty years the manager of the sanatorium in Kosów (near Kolomyia). His methods of therapy (with air, sun, water baths, diet and exercise) were derived from tendencies of European spa system of the time. Tarnawski developed what he learnt abroad, equipping Kosów establishment with some original technical devices. He also introduced a specific ethical approach to the medical treatment. Tarnawski influenced the social life of reborn Poland and his sanatorium had a strong impact on Polish intelligentsia. At the same time it was deeply rooted in the local Polish and Ukrainian traditions of living close to nature.
7
Content available Medycyna naturalna a Kościół katolicki – wątpliwości i uwagi o charakterze biopolitycznym
72%
Rezmer-Płotka K.
Studia Orientalne
|
2021
|
nr 2(20)
157-165
RU
В настоящее время на Западе наблюдается явный рост интереса к восточным практикам, в том числе к натуральной медицине. В этом контексте примечательно, что в 1979 году Всемирная организация здравоохранения (ВОЗ) признала Аюрведу старейшей системой здравоохранения. Аюрведа также стала объектом интереса католической церкви. В статье предпринята попытка изучить отношение этого института к Аюрведе и определить характер возникающих сомнений и оговорок. С этой целью был проведен анализ документа Папского совета по культуре – Папского совета по межрелигиозному диалогу Иисус Христос, Податель воды жизни. Христианские размышления о Новой Эре. Затем в качестве вспомогательной части анализа были включены высказывания избранных представителей Католической церкви. Подтверждена также следующая гипотеза: сомнения и оговорки католической церкви по отношению к Аюрведе носят биополитический характер. На основании анализа документа можно сделать вывод, что католическая церковь трактует и интерпретирует действия, предпринимаемые в рамках Аюрведы, как биополитические практики.
EN
Currently, we observe a significant increase in interest in Eastern practices in the West, including natural medicine. In this context, it is important that in 1979 the World Health Organization (WHO) recognized Ayurveda as the oldest health-care system. Ayurveda has also become an object of interest of the Catholic Church. The article examines the institutions’ attitude toward Ayurveda and determines the nature of doubts and reservations that arise around it. To this end, an analysis of the document of the Pontifical Council of Culture – The Pontifical Council for Interreligious Dialogue Jesus Christ the Giver of the Water of Life. Christian reflection on the New Age was carried out. Subsequently, the statements of selected representatives of the Catholic Church were included in the analysis. The following hypothesis has been verified: the Catholic Church’s doubts and objections to Ayurveda are of biopolitical nature. Based on the analysis of the document, it can be concluded that Catholic Church treats and interprets Ayurveda activities as biopolitical practices.
8
Domowe leczenie przeziebien
72%
Rymanowska M.
Biuletyn Informacyjno-Handlowy. Ośrodek Doradztwa Rolniczego Boguchwała
|
2002
|
nr 01
20-21
9
Phenolic compounds from Aruncus sylvester Kost.
72%
Sokolowska-Wozniak A. , Nowak R.
Herba Polonica
|
2000
|
tom 46
|
nr 4
PL
Metodą dwukierunkowej chromatografii cienkowarstwowej (2D-TLC) oraz wysokosprawnej chromatografii cieczowej (HPLC) analizowano zespół fenolokwasów z liści i kwiatostanów, sylwester. Ogólnie zidentyfikowano trzynaście fenolokwasów. Dominującymi kwasami w badanych surowcach były: kawowy, galusowy, protokatechowy, p-ydroksybenzoesowy, p-kumarowy i ferulowy. Zawartość poszczególnych związków w badanych frakcjach była zróżnicowana i wynosiła w liściach od 0,17 (ug/g do 36,6 ug/g, a w kwiatostanach od 0,005 ug/g do 25,01 ug/g. Z frakcji octanowej kwiatostanów przy pomocy chromatografii preparatywnej otrzymano dwa chromatograficznie jednorodne związki flawonoidowe, które na podstawie chromatografii i analizy spektralnej UV zidentyfikowano jako astragalinę i izokwercytrynę.
EN
Phenolic acids from leaves and inflorescences from A. sylvester were analysed by means of 2D-TLC and RP-HPLC methods. The thirteen acids were identified. The following phenolic acids predominated in all the examined material: caffeic, gallic, protocatechuic, ferulic, p-coumaric, p-hydroxybenzoic. The contents of 5 major phenolic acids was described. It is fairly diversified in cases of different compounds ranging from 0.17 ug/g up to 36.6 ug/g in the leaves and from 0.005 ug/g to 25.01 ug/g in the inflorescences. From the ethyl acetetes fraction of the inflorescences two chromatographically homogenous compounds were isolated. By means of cochromatography with standards and spectral UV analysis these compounds were identified as astragalin and isoquercitrin.
10
Herbs used in pharmacy and their potential on the cosmetic market
58%
Kamczycka B. , Malinowska P.
Towaroznawcze Problemy Jakości. Polskie Towarzystwo Towaroznawcze
|
2015
|
nr 1
11
Content available Different drying technologies and alternation of mycobiots in the raw material of Hyssopus officinalis L.
58%
Raila A. , Lugauskas A. , Kemzuraite A. , Zvicevicius E. , Ragazinskiene O. , Railiene M.
Annals of Agricultural and Environmental Medicine
|
2009
|
tom 16
|
nr 1
93-101
12
XIV Targi Blizej Zdrowia, Blizej Natury
58%
Uszynska-Nowicka U.
Wiadomości Zielarskie
|
2002
|
tom 44
|
nr 01
1
13
Leaf explant response to hormonal traetment in in vitro culture of St.John's wort [Hypericum perforatum L.]
58%
Wojcik A. , Podstolski A.
Biological Letters
|
2005
|
tom 42
|
nr 2 Spec.Vol.
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