Wyniki wyszukiwania - Biblioteka Nauki

1

Transformacje naringeniny przez drożdże Rhodotorula marina

100%

Madej A. , Popłoński J. , Huszcza E.

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tom T. 91, nr 5

856-859

PL

Transformacje naringeniny przez drożdże Rhodotorula marina prowadziły do dwóch produktów hydroksylacji: kartamidyny i izokartamidyny, których stężenie zależało od wieku prehodowli, do której dodawano substrat oraz od czasu jego inkubacji w mieszaninie reakcyjnej. Największą wydajność kartamidyny uzyskano po 24 h inkubacji naringeniny dodawanej do 1-dniowej prehodowli, natomiast największe stężenie izokartamidyny obserwowano po 10 h transformacji naringeniny dodawanej do 3-dniowej prehodowli. Aktywność przeciwutleniająca otrzymanych produktów jest wyższa niż zastosowanego substratu i w przypadku izokartamidyny porównywalna do aktywności α-tokoferolu.

EN

Naringenin was converted to carthamidin and isocarthamidin by Rhodotorula marina yeast. The reaction depended on the age of preculture and time of substrate incubation in reaction mixt. The highest yield of carthamidin was obtained after 24 h of incubation of naringenin added to the 1-day-old preculture, while the highest isocarthamidin concentration was observed after 10 h conversion of naringenin added to the 3-day-old preculture.

2

Naringenin promotes SDF-1/CXCR4 signaling pathway in BMSCs osteogenic differentiation

100%

Wang Y. , Bai S. , Cheng Q. , Zeng Y. , Xu X. , Guan G.

Folia Histochemica et Cytobiologica

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2021

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tom 59

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nr 1

3

Naringenin complexes with copper ions: potentiometric studies

100%

Brodowska K.

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2013

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tom Vol. 77, nr 1

45--53

EN

Flavanones belong to the group of active flavonoid compounds, rarely occurring in the plant kingdom and are found in many foodstuffs (naringenin and derivatives) and medicinal plant materials. Many studies have demonstrated a relationship between dietary intake of phenolic compounds and reduced risk of cancer and cardiovascular disease. Accordingly, during over several years, flavonoids have gained increasing interest and numerous studies have shown that they possess beneficial properties having a great influence on human health. Acid dissociation constants are believed to be the most useful physico-chemical parameters which describe the extent of ionization of functional groups as a function of pH. It is very important in research areas such as pharmaceutical drug discovery and development due to vital role in understanding the pharmacodynamic properties of new drug substances. Flavonoids are characterized by insolubility in water while they are soluble in organic solvents. Exploiting mixed solvents, especially organic solvent – water mixtures, enables a good alternative for researching on compounds which are inconspicuously soluble or insoluble in water. In this study the dissociation constant of naringenin and its complex with Cu(II) have been determined in aqueous – DMSO solvent mixtures to examine the dependence of their acid-base equilibria on number of substrates.

4

Effect of presence of surfactants on results of quantitative determination of flavonoids

100%

Wieloch A. , Zielinski R.

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nr 1

39-49

5

Identification of bioactive polyphenolic compounds and assessment of antioxidant activity of Origanum acutidens

100%

Aras A. , Silinsin M. , Bingol M. N. , Bursal E.

International Letters of Natural Sciences

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2017

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tom 66

EN

The main objective of the current work is to search the antioxidant activities of Origanum acutidens leaves by using DPPH, FRAP and CUPRAC methods severally. Three well known antioxidant compounds (BHA, BHT and ascorbic acid) were used as standards for comparing the extracts. Also, phenolic compounds of Origanum acutidens leaves were identified by UHPLC-ESI-MS/MS. The high concentrations of rosmarinic acid (11158.99 ppb) quinic acid (3200.84 ppb) and naringenin (1238.45 ppb) were detected quantitatively.

6

Evaluation of Helichrysum arenarium flower exudate as an inhibitor on Lolium perenne seed germination under laboratory conditions

80%

Tihomirova Nikolova M. , Yankova-Tsvetkova E. , Stefanova T. , Stoyanov S. , Berkov S.

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2023

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tom 76

7

The inhibitory effect of polyphenols on human gut microbiota

80%

Duda-Chodak A.

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2012

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tom 63

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nr 5

8

Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia-reperfusion in rats; possible implication of tissue antioxidants

80%

Dembinski A. , Warzecha Z. , Konturek S. J. , Ceranowicz P. , Dembinski M. , Pawlik W. W. , Kusnierz-Cabala B. , Naskalski J. W.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 4

EN

Grapefruit seed extract (GSE) has been shown to exert antibacterial, antifungal and antioxidant activity possibly due to the presence of naringenin, the flavonoid with cytoprotective action on the gastric mucosa. No study so far has been undertaken to determine whether this GSE is also capable of preventing acute pancreatic damage induced by ischemia/reperfusion (I/R), which is known to result from reduction of anti-oxidative capability of pancreatic tissue, and whether its possible preventive effect involves an antioxidative action of this biocomponent. In this study carried out on rats with acute hemorrhagic pancreatitis induced by 30 min partial pancreatic ischemia followed by 6 h of reperfusion, the GSE or vehicle (vegetable glycerin) was applied intragastrically in gradually increasing amounts (50-500 µl) 30 min before I/R. Pretreatment with GSE decreased the extent of pancreatitis with maximal protective effect of GSE at the dose 250 µl. GSE reduced the pancreatitis-evoked increase in serum lipase and poly-C specific ribonuclease activity, and attenuated the marked fall in pancreatic blood flow and pancreatic DNA synthesis. GSE administered alone increased significantly pancreatic tissue content of lipid peroxidation products, malondialdehyde and 4-hydroxyalkens, and when administered before I/R, GSE reduced the pancreatitis-induced lipid peroxidation. We conclude that GSE exerts protective activity against I/R-induced pancreatitis probably due to the activation of antioxidative mechanisms in the pancreas and the improvement of pancreatic blood flow.