Wyniki wyszukiwania - Biblioteka Nauki

1

A concurrent presentation of nonspecific colitis as well as likely myocarditis

100%

Heavener T. , Jepson M. , Bushe B. , Thotakura S. , Chiles C.

Progress in Health Sciences

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2018

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tom 8(1)

225-230

EN

An ST-segment elevation myocardial infarction represents a time-sensitive cardiac pathology with utmost importance placed upon timely coronary angiography with percutaneous coronary intervention. While emphasis is placed on atherosclerotic or thrombotic coronary occlusion, it is important to recognize other etiologies which may present in a similar fashion. This case demonstrates a 71-year-old female patient with prior coronary artery disease and stenting who presented with acute abdominal pain and elevated cardiac biomarkers as well as ST-segment elevation on initial EKG. Coronary angiography revealed only mild to moderate coronary lesions and patent stents while echocardiography was essential unchanged from prior evaluation. Computed tomography of the abdomen would show findings suggestive of infectious colitis and empiric antibiotics led to full resolution of symptoms. While no definitive cause for her cardiac manifestations was discovered, the authors propose coronary vasospasm or myo-pericarditis as likely etiologies in response to an overwhelming inflammatory state. The case underscores the importance of formulating a comprehensive differential diagnosis during the initial workup of a ST-segment elevation myocardial infarction.

2

Histopathological characteristics of myocarditis following COVID-19 vaccination: a scoping review

88%

Kalali D. , Anestakis D.

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nr 2

85-90

EN

Introduction: Cases of myocarditis in people who were vaccinated against COVID-19 have been reported in the recent years. Nevertheless, the histopathological features and the pathomechanisms in these cases are still unclear. Hence, a scoping review of existing literature was performed to discover the histopathological features of myocarditis induced by the above-mentioned vaccine. Material and Methods: A search was performed in the PubMed, Scopus and EMBASE databases to retrieve the relevant records, involving analyses of biopsy and autopsy specimens. Baseline characteristics of the patients and the histopathological characteristics of the respective specimens were extracted and recorded. Results: Overall, 24 case reports and case series (involving a total of 54 patients) were included in this scoping review. The following signs of inflammation were present in the specimens: lymphocyte infiltration (64.8%), eosinophilic infiltration (29.6%), neutrophil infiltration (3.7%) and giant-cell formation (1.9%). Other features included myocardial tissue necrosis (20.4%), the presence of the SARS-CoV-2 spike protein (16.7%) and microthrombosis (3.7%). Conclusions: The histopathological characteristics of SARS-CoV-2 vaccine-induced myocarditis were heterogenous, the only common characteristic was the presence of lymphocyte infiltration in more than half of the cases. Studies of unreported past cases may provide further insights into the topic.

3

Kardiologiczne powikłania leczenia klozapiną

75%

Wierzbiński P.

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nr 2

61-65

EN

Clozapine is an effective antipsychotic used in the treatment of drug-resistant schizophrenia. The use of clozapine may be associated with a number of adverse effects. Hematologic side effects, such as neutropenia and agranulocytosis, are most common. Cardiovascular complications are rare, though the incidence of these effects is believed to be underestimated. For this reason, clozapine can be used only if heart diseases and cardiac arrhythmias are excluded based on a comprehensive medical history, complete physical examination and electrocardiography. Myocarditis and cardiomyopathy are serious and potentially life-threatening complications resulting from clozapine therapy. Although the mechanism of these disorders is not fully understood, it is believed that they result from drug hypersensitivity caused by IgE-mediated allergic reaction type I. The symptoms are often untypical and nonspecific, resembling those of influenza. The most common include fever, dry cough, chest pains and leukocytosis. Patients should be closely monitored for resting tachycardia, especially during the first two months of treatment. Monitoring for cardiovascular adverse effects in the first months of therapy allows for a nearly detection of any irregularities and prevention of serious consequences. If myocarditis and cardiomyopathy are suspected, the treatment should be discontinued. Any electrocardiographic irregularities should be consulted with a cardiologist. If clozapine-related myocarditis or cardiomyopathy occur, reintroduction of this drug should not be considered due to the high risk of further complications.

PL

Klozapina jest efektywnym lekiem przeciwpsychotycznym wprowadzanym w przypadkach schizofrenii lekoopornej. Stosowaniu klozapiny mogą towarzyszyć liczne działania niepożądane. Najczęściej opisuje się powikłania hematologiczne: neutropenię i agranulocytozę. Powikłania kardiologiczne są rzadkie, uważa się jednak, że częstość ich występowania jest niedoszacowana. Z tego względu klozapinę można włączyć jedynie po wykluczeniu chorób serca i zaburzeń rytmu na podstawie kompletnego wywiadu, pełnego badania przedmiotowego i elektrokardiogramu. Zapalenie mięśnia sercowego i kardiomiopatia są poważnymi powikłaniami stosowania klozapiny, potencjalnie zagrażającymi życiu pacjenta. Mechanizm powstawania tych zaburzeń nie jest do końca jasny, uznaje się, że wynikają one z nadwrażliwości na lek w wyniku reakcji alergicznej typu I zależnej od IgE. Symptomy są często niecharakterystyczne, mało specyficzne, mogą przypominać objawy grypopodobne. Najczęściej pojawiają się gorączka, suchy kaszel, bóle w klatce piersiowej i leukocytoza. Trzeba zwracać baczną uwagę na tachykardię spoczynkową, przede wszystkim w pierwszych dwóch miesiącach leczenia. Monitorowanie pacjenta pod kątem powikłań kardiologicznych w pierwszych miesiącach stosowania leku pozwala na wczesne rozpoznanie nieprawidłowości i uniknięcie poważnych następstw. W przypadku podejrzenia zapalenia mięśnia sercowego i kardiomiopatii klozapinę należy odstawić. Wszelkie nieprawidłowości w badaniu elektrokardiograficznym powinno się konsultować z kardiologiem. Jeśli wystąpią zapalenie mięśnia sercowego lub kardiomiopatia związana ze stosowaniem klozapiny, z uwagi na duże ryzyko kolejnych powikłań nie zaleca się ponownego włączania leku.

4

Characteristics of Polish avian reovirus strains

51%

Czekaj H. , Samorek-Salamonowicz E. , Kozdrun W.

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nr 2

EN

This work aims to identify 6 virus field isolates, serologically determined as reoviruses. The type of cytopathic effect in cell cultures, physico-chemical properties and antigenic relationship were examined. The strains examined multiplied in CEF and CEK cultures, produced cytopathic effects and plaques, contained RNA in their genome, had no lipid envelope, were stable in an acid environment and belonged to the same serotype but two different subtypes.

5

Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptides

51%

Tang Q. , Huang J. , Qian H. , Xiong R. , Shen D. , Wu H. , Bian Z. , Wei X.

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nr 2

EN

Autoimmune myocarditis develops after the presentation of heart-specific antigens to autoaggressive CD4+ T cells and after inflammation has infiltrated the tissues. To shed light on global changes in the gene expression of autoimmune myocarditis and to gain further insight into the molecular mechanisms underlying the genesis of myocarditis, we conducted a comprehensive microarray analysis of mRNA using an experimental mouse autoimmune myocarditis model via immunization with α-myosin heavy chain-derived peptides. Of over 39,000 transcripts on a high density oligonucleotide microarray, 466 were under-expressed and 241 over-expressed by ≥ 1.5-fold compared with the controls in BALB/C mouse with autoimmune myocarditis. In this paper, we list the top 50 up-regulated genes related to the immune response. These altered genes encode for leukocyte-specific markers and receptors, the histocompatibility complex, cytokines/receptors, chemokines/receptors, adhesion molecules, components of the complement cascade, and signal transduction-related molecules. Interestingly, matrix metalloproteinases (MMPs) such as MMP-3 and MMP-9 were up-regulated, as further revealed by the reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry assays. This indicates that MMPs may act as major regulators of the cytokine profile. Together, these findings provide new insight into the molecular events associated with the mechanism of the autoimmune genesis of myocarditis.

6

Bakteryjne zapalenie mięśnia sercowego i wsierdzia u psa - opis przypadku

44%

Stabinska-Smolarz M. , Szalus-Jordanow O. , Czopowicz M. , Moroz A. , Mickiewicz M. , Chrobak D. , Sapierzynski R. , Petelicka H. , Frymus T.

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tom 17

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nr 04