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Diagnostic and therapeutic challenges of Myasthenia Gravis: A report of 2 cases

100%

Poleszak J. , Szabat P. , Jasielski P. , Szabat M. , Petit V. , Fidor A. , Rejdak K.

tom 31

138-145

Myasthenia gravis (MG) is an autoimmune disease that affects the neuromuscular junction and is characterized by muscle weakness. We present two clinical cases of patients with MG. The first case of the patient presents an uncharacteristic clinical picture in the form of dyspnoea with stridor. The second clinical case presents a severe form of MG, resistant to pharmacological cholinergic and immunosuppressive treatment, which resulted in a satisfactory improvement after eight plasmapheresis treatments and the conversion of pyridostigmine to the ambenonium.

Diagnostic and therapeutic challenges of myasthenia gravis: a report of 2 cases

63%

Poleszek J. , Szabat P. , Jasielski P. , Szabat M. , Petit V. , Fidor A. , Rejdak K.

2020

tom 31

Immunological system status and the appearance of respiratory system disturbances in thymectomized patients

63%

Krawczyk P. , Adamczyk-Korbel M. , Kieszko R. , Korobowicz E. , Milanowski J.

2007

tom 55

nr 1

Myasthenia, spondylitis and Enterococcus faecalis endocarditis

51%

Stollberger C. , Thalmann M. , Finsterer J.

tom 60

nr 3

Familial form of autoimmune myasthenia gravis in a dog: a case report

51%

Drzewiecka A. , Pazdzior K. , Rotkiewicz T. , Lew S. , Kwiatkowska M.

tom 67

nr 05

This paper describes clinical and pathomorphological features of myasthenia gravis in a 7-year-old male German Shepherd dog. At clinical examination, many neurological deficits as well as swallowing and urinating problems were detected. Radiological examination revealed megaoesophagus and the ELISA test showed an elevated serum acetylcholine receptor (AChR) antibody titer. No improvement was observed after the administration of edrophonium hydrochloride. The diagnosis of myasthenia gravis was confirmed by electromyography. Despite the administration of pyridostygmine bromide, dexamethasone and antibiotics, no improvement followed, and the dog died. Necropsy was conducted: histopathological changes in the esophagus, cranial tibial muscle and lungs were described as muscular atrophy, muscular fibrosis and aspiration pneumonia. The dog’s littermate was examined and showed an elevated AChR antibody titer too, but was asymptomatic.

Immunomodulatory activity of G-actin fragments containing a thymopentin-like sequence

51%

Siemion I. Z. , Strug I. , Wyslouch-Cieszynska A. , Nowak E. , Wieczorek Z.

nr 5-6