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Chemiluminescence in activated murine macrophage J774.2 cells modulated by flavones

100%

Krol W. , Czuba Z. P. , Pietsz G. , Dworniczak S.

Folia Histochemica et Cytobiologica. Supplement

1997

tom 35

nr 2

Modulation of murine macrophages and T lymphocytes by lysozyme dimer

86%

Obminska-Mrukowicz B. , Szczypka M. , Gaweda B.

Polish Journal of Veterinary Sciences

2002

tom 05

nr 4

The effects of lysozyme dimer (2 and 20 μg/kg) administered i.p. once and four times to mice on the phagocytic and killing ability of peritoneal macrophages, interleukin-1 (IL-1) production by murine macrophages stimulated in vitro with lipopolisaccharide of E. coli and expression of thymocyte, splenocyte and mesenteric lymphonode cell CD3+, CD4+ and CD8+ markers were studied. It was found that lysozyme dimer administered once or four times at doses of 2 (μg/kg and 20 μg/kg augments the phagocytic and killing activity of peritoneal macrophages. The strongest stimulating effect was noted after four injections of lysozyme dimer at a dose of 20 μg/kg. Moreover, lysozyme dimer is able to modulate the production of IL-1 by murine macrophages stimulated in vitro with LPS. Exposure to four doses of lysozyme dimer (20 μg/kg) enhances the synthesis and release of IL-1, but this drug administered once (2 μg/kg and 20 μg/kg) or four times (2 μg/kg) decreases IL-1 production by peritoneal macrophages. It was also found that administration of lysozyme dimer at a dose of 20 μg/kg, irrespective of the number of doses applied, increases the percentage of CD4+ thymocytes and splenocytes. Moreover, exposure to four doses of lysozyme dimer (2 and 20 μg/kg) increases the percentage of CD4+ and CD8+ mesenteric lymphonode cells.

Antiparasitic properties of homoallylamines and related compounds

86%

Gomez-Barrio A. , Montero-Pereira D. , Nogal-Ruiz J. J. , Escario J. A. , Muelas-Serrano S. , Kouznetsov V. V. , Vargas Mendez L. Y. , Urbina Gonzales J. M. , Ochoa C.

Acta Parasitologica

2006

tom 51

nr 1

A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.

Japanese quince (Chaenomeles japonica) leaf phenol extract as modulator of the inflammatory response in lipopolysaccharide-triggered murine macrophage RAW 264.7 cells

72%

Chojnacka K. , Owczarek K. , Caban M. , Sosnowska D. , Polka D. , Koziolkiewicz M. , Fichna J. , Lewandowska U.

Journal of Physiology and Pharmacology

2020

tom 71

nr 6