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Content available remote Teoria kwantykuł Kazimierza Fajansa
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tom [Z] 52, 5-6
361-365
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In Fajans's interpretation a chemical molecule consists of quanticules and atomic cores (or atomic nuclei) electrostatically interacting and mutually polarizing each other. A quanticule is a precisely defined group of electrons whose character will be explained in many examples presented in this article.
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Explanation of forming chemical compounds is based on two concepts contradicting each other: one of them stresses similarities of particular parts merging together in a single molecule, and the other shows their opposing properties. During subsequent periods in history, chemists were alternately in favour of one theory and then the other. In reality, parts of molecules are bound together both on the basis of their similarities and opposites. However, in each type of molecule share of these parts is different: from the smallest to absolutely predominant.
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Two phenomenon influence on the temperature dependence of component of polarizability tensor. First one is the change of distance between electrons and protons with temperature. The second is the conformation change of molecule. From the two reasons mentioned above the electron proton distance change is only the linear function of temperature. It gives the possibility of separation of two part of ɑII and ɑI changes in polarizability tensor of liquid crystal molecule. In this work the polarizability tensor component changes was separated for CCH 7 liquid crystal and the implications of the results are discussed.
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Content available remote Some non-homogeneous Hardy spaces on locally compact Vilenkin groups
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The laminin receptor precursor (LRP) has been the center of intense controversy and interest for over a decade. Chief among these controversies is the putative multifunctional aspect of this molecule: as a ribosomal-associated protein (p40) and/or as the precursor for the 67kDa high-affinity laminin receptor (67LR), neither of which have been definitively established. Other controversies include the presence of more than one 67kDa laminin receptor protein. However, interest in the molecule is sustained because of its vital function in the cell as a component of the translational machinery and due to its constant up-regulation in cancer cells with the invasive and metastatic phenotype and in association with poor prognosis. Recently, while studying the autoimmunogenicity of a species conserved 37-44 kDa oncofetal antigen (37kDa OFA), the authors of this paper, using amino acid sequencing of isolated OFA-peptides, cDNA cloning and sequencing and antigens-antibodies cross reactivity as well as antigens-T cell recognition reactions, identified the 37kDa OFA as precursor or immature laminin receptor protein.
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A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-y-Abu-Asn- Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was de­signed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral im­mune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.
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Recent literature on the evolution and interrelationships of the Caryophyllidea based on molecular and morphological criteria is reviewed. Molecular analyses with SSU rDNA, LSU rDNA and ef-1 alpha reaffirms the basal or near basal position of these nonozoic cestodes. Major emphasis is on an evaluation of the scoring in morphological character matrices used in cladistic studies. Suggested changes to present scoring are: uterus is dorsal; scolex is afossate, fossate or difossate with little support for monofossate; ciliated coracidium is absent; vitellaria are circum-cortical and circum-medullary; testes are cortical and medullary; metacercoid stage is absent; and the spermatozoan lacks a crested body, flagellar rotation and proximodistal fusion. Of the 41 recognized genera of the Caryophyllidea, 59% have an afossate scolex and the remainders are fossate. The use of a new character, “nuclear vacuole” in the nucleus of mature vitellocytes, is suggested. To aid in identifying cestode body types in an evolutionary context, they are designated as monopleuroid, polypleuroid and strobila. Tabulated differences between the monozoic Caryophyllidea and polyzoic eucestodes suggest that the two groups may warrant separate taxonomic status. The question of whether or not the monozoic state is primary or secondarily derived is not resolved. Using the life cycle characterstics of the Pseudophyllidea and of Archigetes as models, it is hypothesized that progenesis may have played a major role in the evolution of the Caryophyllidea. If the role of progenesis can be substantiated through total evidence incorporating cytohistological data, then the monozoic condition becomes coincidental and the hypothesis is not supported that the Caryophyllidea are ancestral and preceded polyzoic eucestodes.
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Quantitative estimation of the structure anticancer activity relationship in a series of macrocyclic Schiff bases of 2,6-bis(formylaryloxymethyl)pyridines was carried out by the topological approach. Correlation equations describing the relationship between the anticancer activity and structural parameters of the molecules studied and descriptors characterizing their structure were obtained on the basis of in vitro screening data. The influence of structure of the investigated substances as reflected by the parameters studied on the anticancer activity, was established.
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Computer modelling related to the real dimensions of both the whole filament and the myosin molecule subfragments has revealed two alternative modes for myosin molecule packing which lead to the head disposition similar to that observed by EM on the surface of the cross-bridge zone of the relaxed vertebrate skeletal muscle thick fil­aments. One of the modes has been known for three decades and is usually incorpo­rated into the so-called three-stranded model. The new mode differs from the former one in two aspects: (1) myosin heads are grouped into asymmetrical cross-bridge crowns instead of symmetrical ones; (2) not the whole myosin tail, but only a 43-nm C-terminus of each of them is straightened and near-parallel to the filament axis, the rest of the tail is twisted. Concurrent exploration of these alternative modes has re­vealed their influence on the filament features. The parameter values for the filament models as well as for the building units depicting the myosin molecule subfragments are verified by experimental data found in the literature. On the basis of the new mode for myosin molecule packing a complete bipolar structure of the thick filament is cre­ated.
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