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1 Medycyna Weterynaryjna

1 2008

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Wplyw metisoprinolu zastosowanego in ovo na odsetek subpopulacji limfocytów T CD3 plus, CD4 plus i CD8 plus u indyków

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Stenzel T. , Tykalowski B. , Andrzejewski M. , Koncicki A.

tom 64

nr 09

1157-1160

The aim of the research was to determine the influence of a synthetic immunomodulator methisoprinol applied in ovo as a 10% solution in doses of 5 mg per egg (group I) and 20 mg of active substance per egg (group II) on the 26th day of incubation on T-lymphocyte subpopulations in the blood and spleen of 5-day-old turkeys hatched from the treated eggs. The control group (group III) were turkeys hatched from eggs in standard hatchery conditions (without in ovo injections). The percentage of T-lymphocyte subpopulations was determined by flow cytometry using specific monoclonal anti-T CD3⁺, CD4⁺ and CD8⁺antibodies and an EPICS XL apparatus. It was demonstrated that methisoprinol applied in ovo in doses of 5 mg per egg stimulated non-specific mechanisms of humoral immunity in 5-day-old turkey poults hatched from the treated eggs, which resulted in a higher percentage of CD3⁺ and CD4⁺ T-lymphocytes in their blood and spleen. Methisoprinol applied in ovo in doses of 20 mg per egg stimulated mainly non-specific mechanisms of cellular immunity in 5-day-old turkey poults hatched from the treated eggs, as evidenced by a higher percentage of CD8⁺ T-lymphocytes in the spleen.