Wyniki wyszukiwania - Biblioteka Nauki

1

Transport and metabolic effects of carnitine and acylcarnitines in brain

100%

Nalecz K. A. , Nalecz M. J.

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1993

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tom 40

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nr 3

2

Metabolic effects of dietary apple seed oil in rats

84%

Fotschki B. , Jurgonski A. , Juskiewicz J. , Zdunczyk Z.

Żywność Nauka Technologia Jakość

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2015

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tom 22

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nr 1

EN

The aim of this study was to determine the fatty acid profile of apple seed oil and its effects on the caecal functions, blood lipids, and markers of antioxidant status and inflammation in rats. A nutritional experiment was performed on Wistar rats allocated to 3 groups of 8 animals each. The animals were fed with a diet containing different sources of fat: pork lard (group LA), rapeseed oil (group RO) and apple seed oil (group AO). Apple seed oil was rich in linoleic acid and oleic acids (57 % and 32.3 % of total fatty acids, respectively). The short chain fatty acid concentration in the caecal digesta was comparable among all groups, whereas the ammonia concentration was lower in groups AO and RO than in group LA (0.32 and 0.3, respectively vs 0.42 mg/g). The plasma alanine (ALT) and aspartate transaminase (AST) activities also decreased in the AO and RO groups (ALT, 19.34 and 19.81, respectively vs 30,7 U/L and AST, 115.1 and 107, respectively vs 138.3 U/L) The plasma triacylglycerols (TG) concentration and the atherogenic index (ATI) of plasma were significantly decreased in the AO group compared to the LA group (TG, 1.79 vs 2.62 mmol/L and ATI, 0.095 vs 0.313). Apple seed oil is a valuable source of unsaturated fatty acids and its dietary addition has slightly better metabolic effects on rat organism than does rapeseed oil.

PL

Celem pracy było określenie zawartości kwasów tłuszczowych w oleju z nasion jabłka oraz ocena jego wpływu na funkcjonowanie jelita ślepego, profil lipidowy krwi, markery stresu oksydacyjnego oraz stanu zapalnego szczurów. Eksperyment żywieniowy przeprowadzono na szczurach Wistar przydzielonych do 3 grup po 8 osobników w każdej. Zwierzęta żywiono przez 8 tygodni dietami zawierającymi następujące rodzaje tłuszczu: smalec wieprzowy (grupa LA), olej rzepakowy (grupa RO) oraz olej z nasion jabłka (grupa AO), który charakteryzował się znaczną zawartością kwasu oleinowego oraz linolowego (odpowiednio 32,3 % oraz 57 % całkowitej zawartości kwasów tłuszczowych). Po 8 tygodniach doświadczalnego żywienia stężenie krótkołańcuchowych kwasów tłuszczowych w treści jelita ślepego szczurów było porównywalne we wszystkich grupach doświadczalnych, natomiast stężenie amoniaku było niższe w grupach AO oraz RO w porównaniu z grupą LA (0,32 i 0,3, w porównaniu z 0.42 mg/g). W grupach RO i AO odnotowano również spadek aktywności aminotransferazy asparaginowej oraz alaninowej oznaczonej w osoczu badanych zwierząt. Stężenie triacylgliceroli w (TG) w osoczu krwi oraz aterogenność osocza (ATI) w grupie AO były istotnie niższe w porównaniu z grupą LA (TG, 1.79 w porównaniu z 2.62 mmol/L oraz ATI, 0.095 w porównaniu z 0.313). Dodatek do diety oleju z nasion jabłka, będącego cennym źródłem nienasyconych kwasów tłuszczowych, wpływa w sposób nieznacznie bardziej korzystny na organizm szczura niż powszechnie stosowany w żywieniu olej rzepakowy.

3

Short-term calorie restriction and refeeding differently affect lipogenic enzymes in major white adipose tissue depots of young and old rats

84%

Wronska A. , Sledzinski T. , Goyke E. , Lawniczak A. , Wierzbicki P. , Kmiec Z.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 1

4

Prolactin - not only lactotrophin a 'new' view of the 'old' hormone

84%

Ignacak A. , Kasztelnik M. , Sliwa T. , Korbut R. A. , Rajda K. , Guzik T. J.

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2012

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tom 63

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nr 5

5

Some metabolic effects in rat brain synaptosomes after exposure to lead in vivo and in vitro

84%

Struzynska L. , Dabrowska-Bouta B. , Lenart J. , Zborowski J. , Rafalowska U.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1994

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tom 42

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nr 1

6

Reactive oxygen species [ROS] and reactive nitrogen species [RNS] alter metabolic effect of insulin in rat L6 satellite cells

67%

Orzechowski A. , Grzelkowska K.

Polish Journal of Veterinary Sciences

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2000

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tom 03

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nr 1

EN

This study investigates the effect of superoxide anion radical (02); hydrogen peroxide (H202), nitric oxide (NO) and peroxynitrite (ONOO), which often accompany inflamed, endotoxic or exercised muscle on insulin action in DTsatellite cells. In order to induce quiescence, rat L6 myoblasts were subjected to transition from G2/M to Gl phase by the application of serum-reduced medium. Insulin stimulating effect on cell mitogenicity and anabolism was dose-dependent and hormetic. Application of H202 alone enhanced protein synthesis with dose-dependency but had no effect on mitogenicity. While insulin and H202 were used together, (i.e. at low H202 dose) insulin action was not affected regardless of the combination used, except the loss of dose- dependency on protein synthesis, but for 100 μM of H202 insulin action ceased abruptly and totally. Since there were no additive effects of both factors, we conclude that H202 may contribute to the insulin-induced anabolic reaction, however, below 100 The application of 02- donor stimulated protein synthesis and slightly inhibited [cell proliferation] though dose-response pattern was not observed suggesting apparent limitations to 02- diffusion into the cell. Moreover 02- inhibited both insulin-enhanced mitogenicity and protein synthesis by abrogating dose-response fashion of insulin action. The introduction of NO and ONOO- donors alone to control systems inhibited cell proliferation in a dose-dependent manner having no effect on protein synthesis (except the low doses of SIN-1). Insulin-stimulated syntheses of both DNA and protein were inhibited in a dose- dependent manner by SIN-1 (NO and 02' donor). In the presence of SNP (NO donor) mitogenic effect of insulin was abolished whereas protein synthesis was diminished only by the highest SNP concentration used (0.5 mM). Taken together, these results have shown that hydrogen peroxide (H202), nitric oxide (NO) and peroxynitrite (ONOO ) provide a good explanation for developing resistance to growth promoting activity of insulin in satellite cells under conditions of oxidant stress.

7

Unsaturated trans fatty acid - nutritional problem?

51%

Bartnikowska E. , Obiedzinski M.

Polish Journal of Food and Nutrition Sciences

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1997

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tom 06

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nr 3

EN

This review summarizes the up-to-date data on the consumption pattern of trans fatty acids in different countries including Poland, as well as the metabolism and metabolic effects of trans fatty acids in human organism. The health hazards linked with the consumption of trans fatty acids are also discussed.